Abstract: The present invention relates to a method for displaying a graphical interface having display areas including a reference area, wherein each file of a file set is displayed in the form of an icon in one of the display areas, and each file of the file set contains a unique identifier identifying the file, and processing a command for inserting into the file set a selected pre-existing file which does not belong to the file set, the processing of the insertion command including the steps of: generating a new file in the file set, from the content of the selected pre-existing file, generating a unique identifier identifying the new file, and inserting into the new file the generated unique identifier and a reference link generated from a file identifier corresponding to each icon located in the reference area.

Abstract: Eyeglass lenses have at least a portion of their edge shaped to reflect light away from an eye of a wearer, such as the edge being disposed at an acute angle with respect to a principal axis of the lens, toward the back surface of the lens. Alternatively or additionally, the edge may include a plurality of edge surfaces disposed at an acute angle with respect to a principal axis of the eyeglass lens, toward the back surface of the eyeglass lens, or at least one edge surface may be disposed at an acute angle with respect to the front surface of the lens and at least one other edge surface may be disposed at an acute angle with respect to the back surface of the lens. As yet another alternative, the edge may be rounded with progressive angles to have an edge axis directed away from the wearer's eye.

Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

Abstract: A class D amplifier receives and amplifies a differential analog signal which is then differentially integrated. Two pulse width modulators generate pulse signals corresponding to the differentially integrated analog signal and two power units generate output pulse signals. The outputs the power units are coupled to input terminals of integrators via a resistor feedback network. An analog output unit converts the pulse signals to an output analog signal. The differential integration circuitry implements a soft transition between mute/un-mute. In mute, the integrator output is fixed. During the soft transition, the PWM outputs change slowly from a fixed 50% duty cycle to a final value to ensure that no pop noise is present in the output as a result of mode change.

Abstract: Provided herein are methods and kits related to use of vanin-1 (VNN1) expression for assessing responsiveness to steroid treatment in subjects with asthma and for treating subjects with asthma.

Abstract: Compounds of formula (I) have checkpoint kinase 1 (CHK1) inhibitory activity: wherein R1, R2, R5 and R6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, trifluoromethoxy, methylamino and dimethylamino; R3, and R4 are independently selected from hydrogen, hydroxy, C1-C3 alkyl, fluoro-(C1-C3)-alkyl, hydroxy-(C1-C3)-alkyl, C1-C3 alkoxy, fluoro-(C1-C3)-alkoxy, hydroxy-(C1-C3)-alkoxy, —N(R11)—R12, -Alk-N(R11)—R12, —O-Alk-N(R11)—R12, —C(?O)OH, carboxy-(C1-C3)-alkyl, or —C(?O)—NH—R13; Alk is a straight or branched chain divalent C1-C6 alkylene radical; R7 and R8 are independently selected from hydrogen, hydroxy, or C1-C3 alkoxy; X is a straight chain divalent C1-C3 alkylene radical, optionally substituted on one or more carbons by R9 and/or R10; W is selected from —C(?O)—N(—R16)— or —N(—R17)—C(?O)—; Y is hydrogen, C1-C3 alkyl, C1-C3 alkoxy, or halo; and Q is selected from optionally substituted phenyl, optionally substituted cyclohexyl, or an optionally substitu

Abstract: The invention relates to a windscreen wiper motor (10), having a housing (12) for accommodating a gearing arrangement which comprises a gear wheel (20) rotatably mounted in a shaft (13), which gear wheel has, on its outer circumference, a toothing (21) which interacts with a counterpart toothing (19) on a drive shaft (15), wherein the shaft (13) is received in a mount (22; 22a to 22c), which is constructed as a bore, of the housing (12) in an eccentric bush (25; 25a to 25c) for setting the distance (a) between the shaft (13) and the drive shaft (15), and wherein a press fit is formed at least in regions between the mount (22; 22a to 22c) and the eccentric bush (25; 25a to 25c).

Abstract: A system and method for processing objects having contaminating particles includes the steps of shredding the objects in a shredding chamber to form a plurality of shredded fragments, wherein the shredding chamber is arranged to be substantially combustion resistant, and removing the contaminating particles from the plurality of shredded fragments.

Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: To provide an electric pipette in which the impact resistance against the dropping of the electric pipette is elevated, the external breakage of the device and the damage of operation performances are reduced, and the discharging performance of the device is maintained and ensured. An electric pipette 100 including a main casing 1, an operation switch 14, a hand grip 15, a display-operation section 9, a release switch 12 and a finger rest 16, in which at least one shock absorber 201 to 206 disposed on at least one apex of at least one line among a line LF, a line LB, a line LL, a line LR and a line LU, which are prepared by drawing lines between two or more projecting sites in each of a front surface 100F, a back surface 100B, a left side surface 100L, a right side surface 100R and an upper surface 100U.

Abstract: The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD 146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

Abstract: A boost converter circuit receives an input power supply voltage and produces an output boosted supply voltage. The circuit includes a voltage regulator, boosting circuitry, and a timing controller. The voltage regulator provides a regulated voltage to the boosting circuitry, which controls switching a transistor to drive the output boosted supply voltage; and the timing controller controls switching the boost circuit from the start-up mode to the normal operation mode. In start-up mode, the regulated voltage is generated from the input power supply voltage. During normal operation mode, the regulated voltage is generated from the output boosted supply voltage. The circuitry performs a low-power start-up when the input power supply voltage is low, and maintains efficient low-power operation by driving the transistor to produce the output boosted supply voltage as the input power supply voltage decreases.

Abstract: The present invention relates to methods for selecting binders by phage display and masked selection. More particularly, the present invention relates to a method for selecting a plurality of binders specific for at least one relevant target comprising screening a phage binder library of binders against the relevant target in presence of a plurality of binders obtained from a library of binders directed against at least one irrelevant target and positively selecting the binders that are specific for the at least one relevant target.

Abstract: A carrier communication method and system based on charging-discharging of an electric vehicle and a carrier device are disclosed. The carrier communication method comprises: determining whether a carrier signal from a peripheral apparatus is detected at an interface harness and if yes, determining whether the carrier signal is correct, when the electric vehicle is powered on to start; when the electric vehicle detects the carrier signal and the carrier signal is correct, receiving the carrier signal via the interface harness; and performing a coupling and filtering on the carrier signal to convert the carrier signal into a standard carrier signal and demodulating the standard carrier signal into a digital signal to obtain information about the peripheral apparatus.

Abstract: Non-lethal weapon includes a housing, a barrel insertable into the housing and a barrel locking mechanism. The non-lethal weapon may be adapted for spraying a pepper extract onto a potential attacker in order to disable the potential attacker. The barrel is adapted to hold a canister of the pepper extract under pressure. The barrel may be rotatable to lock the barrel into the housing. A longitudinal axis of the barrel is angled upward at a substantial angle relative to the longitudinal axis of the housing or relative to the upper surface of the housing when the weapon is used. The non-lethal weapon includes a conical orifice adapted to spray the pepper extract over an opening angle of between 70 and 120 degrees.

Abstract: Apparatus and methods enable active compensation for unwanted discrepancies in the superconducting elements of a quantum processor. A qubit may include a primary compound Josephson junction (CJJ) structure, which may include at least a first secondary CJJ structure to enable compensation for Josephson junction asymmetry in the primary CJJ structure. A qubit may include a series LC-circuit coupled in parallel with a first CJJ structure to provide a tunable capacitance. A qubit control system may include means for tuning inductance of a qubit loop, for instance a tunable coupler inductively coupled to the qubit loop and controlled by a programming interface, or a CJJ structure coupled in series with the qubit loop and controlled by a programming interface.

Abstract: Assembly for the production of a wiping system, comprising a terminal part (2) of a wiper arm designed to move a wiper blade (3) over the surface to be wiped and a hydraulic connector (30) comprising at least one piping element (31, 32) for conveying a liquid to the wiper blade (3), the said terminal part comprising at least one means (8) for supporting the said hydraulic connector ensuring that it is held longitudinally with reference to the wiper arm. It is characterized in that the said supporting means allows a movement of the said hydraulic connector (30) in a direction convergent with the longitudinal direction.

Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.

Abstract: A user terminal comprising: i) a housing; ii) a main radio frequency (RF) antenna disposed within an interior of the housing; and iii) a boost antenna mounted on an exterior of the housing and in close proximity to the main RF antenna. The first antenna segment of the boost antenna is configured to be magnetically coupled to the main RF antenna and a second antenna segment of the boost antenna is configured to be magnetically coupled to an antenna of a wireless device disposed close to the housing. The first antenna segment magnetically couples to RF signals transmitted to and received from the main RF antenna in a first direction. The second antenna segment magnetically couples to RF signals transmitted to and received from the RF antenna of the wireless device in a second direction. The first direction and the second direction are substantially orthogonal to each other.