Abstract: Systems and methods are described for monitoring usage of a medicament dispenser—particularly an inhaled medicament dispenser. While operating in a low-power mode, a first sensor is monitored for a signal indicative of handling of the medicament dispenser by a user. In response to detecting such handling, the device exits the low-power mode and begins to monitor a second sensor for a signal indicative of dispensing of the medicament. The usage monitoring device can be embodied as an attachment configured to be selectively coupled to one of a variety of different inhalers including, for example, a Diskus-type inhaler and a Respimat-type inhaler.

Abstract: An electrical apparatus, including: a circuit breaker having a breaking capacity and a breaking current; a DC voltage source including two batteries connected in parallel, connected in series with the circuit breaker, the sum of short-circuit currents of the batteries being greater than the breaking capacity, each battery including: a first branch including storage batteries and a switch connected in series; a second branch connected in parallel with the first branch and including a free-wheeling diode; an ammeter measuring output current; and a control circuit configured to detect a short-circuit. The control circuits simultaneously keep a majority of switches open and close one switch to apply a current passing through the circuit breaker which is higher than the breaking current and lower than the breaking capacity.

Abstract: This machine includes a tool (30) actuated by an actuating module (32); a dual-frequency satellite positioning module (40) able to take into account corrections relative to the disruptions affecting the propagation of radio navigation signals emitted by each of the visible radio navigation satellites and that are caused by the ionosphere, so as to determine an absolute position of the machine, and consequently of the tool, which is precise to within a centimeter; and a computer (50) able to compare the instantaneous absolute position of the tool and an absolute position of a current revisiting point, selected from among the revisiting points of a revisiting plan, the computer then being able to command the actuation module.

Abstract: The present invention relates to a device for supporting a pair of windshield wipers (12, 26), each of which is provided with a structural element and a wiper blade (16, 30), the supporting device (10, 101, 102, 103, 104, 105, 200, 201) comprising a first and a second recess (14, 28), each of which is provided with means for retaining the respective structural elements of the two wipers (12, 26), characterized in that the recesses (14, 28) have an opening leading onto a single side of a supporting plane (P) in order to enable the insertion of the pair of wipers (12, 26) into the respective recesses (14, 28) from a single side of the supporting plane (P). The present invention also relates to a supporting assembly comprising a plurality of supporting devices, as well as to corresponding packaging and to a corresponding assembly method.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: Method of controlling a motor vehicle windscreen wiper motor, powered and controlled by pulse width modulation (PWM) with duty ratio (T) of determined value, in which the instantaneous fundamental period of the modulated pulses is switched successively between at least two discrete period values (T1, T2), the duty ratio (T) of the pulses (PWM) being substantially established at a determined value for at least one determined duration (Tc) of switching of the modulated pulses. Application to the reduction of the EMC noise level in the radio frequency bands to be protected.

Abstract: An apparatus for regulating temperature is presented. The apparatus comprises: a shell comprising a first cavity and a second cavity; and an inner valve body and an outer valve body disposed in the shell between the first cavity and the second cavity, wherein the inner valve body is movable relative to the outer valve body, and the outer valve body is movable within the shell. Depending on the temperature inside the shell, the inner valve body and the outer valve body can substantially seal the first cavity from the second cavity. The inner valve body and the outer valve body can also provide, respectively, a first flow path and a second flow path between the cavities, depending on the temperature.

Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

Abstract: This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic ?-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Abstract: The present invention relates to glucommannan oligosaccharides and polysaccharides that possess one or more properties selected from skin regeneration, wound healing and skin augmentation. More particularly, the invention relates to the use of glucomannan oligosaccharides and polysaccharides for one or more of skin regeneration, wound healing and skin augmentation agents in a mammal. The invention also relates to a pharmaceutical formulation for treating skin of a subject comprising an active component comprising glucomannan in a suitable diluent, excipient or physical form such as dermal scaffold or sponge, the active component being capable of promoting an accumulation of fibroblasts in the skin and stimulating production of collagen in the skin.

Abstract: A system and method for containing a flame originating from a flame source within a fluid containing enclosure includes de-energizing the flame source when the fluid falls below a pre-established level or when the water temperature exceeds a pre-established level.

Abstract: A reference current path carries a reference current. A first transistor is coupled to the reference current path. A second transistor is also coupled to the reference current path. The first and second transistors are connected in parallel to carry the reference current. The first transistor is biased by a first voltage (which is a bandgap voltage plus a threshold voltage). The second transistor is biased by a second voltage (which is a PTAT voltage plus a threshold voltage). The first and second transistors are thus biased by voltages having different and opposite temperature coefficients with a result that the temperature coefficients of the currents flowing in the first and second transistors are opposite and the reference current accordingly has a low temperature coefficient.

Abstract: An electrode plate, method for manufacturing an electrode plate, and method of testing an electrode plate enable efficient production of robust flowing electrolyte batteries. The method of testing an electrode plate includes forming a frangible portion in the electrode plate; providing a seal around a periphery of the electrode plate, wherein the periphery extends across the frangible portion; applying a gas adjacent a surface on a first side of the electrode plate; and detecting whether there is a presence of the gas adjacent a surface on a second side of the electrode plate, if the electrode plate passes testing, the frangible portion is removed from the electrode plate to define a cut-away region. The electrode plate is then positioned in a battery cell stack including a plurality of other electrode plates. A manifold is then attached to the cell stack adjacent the cut-away region of the electrode plate.

Abstract: Disclosed are methods and uses for conditioning the scalp against the onset, return or worsening of symptoms associated with dandruff, comprising applying glycerol or a composition comprising glycerol to the scalp of an individual.

Abstract: A cosmetic composition is disclosed comprising particle active; opacifying particles having a refractive index of at at least 1.7 and cosmetically acceptable carrier. The particle active comprises (i) water-insoluble shell component comprising inorganic material and having a refractive index of from 1.3 to 1.8; and (ii) core component comprising volatile liquid and having a refractive index of at least 1.2.

Abstract: The invention relates to a vehicle lock for locking doors or hatches of motor vehicles, in particular doors or hatches of agricultural machines, such as tractors, or construction machines, having a rotary latch assembly having two rotatably supported rotary latches for encompassing and retaining a striker pin in a preliminary latching position or a final latching position; a pawl for locking the two rotary latches in the preliminary latching position or final latching position thereof; and a closing device, to which the rotary latches are connected in such a way that the rotary latches can be rotatably driven in a respective rotary latch closing direction from the preliminary latching position to the final latching position. The invention further relates to a vehicle having such a vehicle door lock.

Abstract: This substrate for power electronic components comprises a colaminated multilayer composite material containing at least one internal layer (8) made of a material having a thermal expansion coefficient chosen depending on the expansion coefficient of said components, and external layers (6, 7) made of a thermally conductive material covering on either side said internal layer and connected together by wells (P) made of a thermally conductive material, said wells being arranged in the internal layer. Each interior layer forms an insert localized in a zone for mounting the components so that the external layers extend laterally beyond the insert.

Abstract: Blank (1) for assembling a device for packaging at least one windscreen wiper, said blank (1) being of elongate shape and comprising at least two adjacent longitudinal areas (2, 3) that can be articulated to one another via a longitudinal folding line (4), each longitudinal area (2, 3) being intended to form a longitudinal face of the packaging device, at least one of the longitudinal areas (2, 3) being further articulated at each of its longitudinal ends to an end area (21, 22; 31, 32), via a transverse folding line (5, 6; 7, 8), each end area (21, 22; 31, 32) being adapted to form a substantially transverse end face of the packaging device, said blank (1) being characterized in that it includes, at one of its longitudinal ends at least, longitudinal shock absorbing means (11) situated at the level of the longitudinal folding line (4) and spaced longitudinally and/or extending to a point spaced longitudinally from the transverse folding line or lines (5, 6; 7, 8) of the corresponding longitudinal end of the