Abstract: Desired skin colour is a major unmet consumer need around the world and especially in Asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone. One solution is to use biological actives that reduce the activity of melanocyte cells in skin. These cells, present in the basal layer of the epidermis, make the dark coloured pigment melanin and export it, in small export vesicles called melanosomes, to the neighbouring keratinocytes. It is well described in the literature that compounds which reduce melanin synthesis when topically applied to the skin will reduce skin darkness over time and can generate a more even skin tone. Tyrosinase is a very popular target for the regulation of melanocyte pigment production. However effective inhibitors of tyrosinase are bedevilled by safety issues causing, for example, melanocyte cell death, permanent depigmentation, irritation and allergic reactions.

Abstract: A cradle device removably stores a terminal device having a first recess. This cradle device includes a second recess, a locker, and a push up member. The second recess is capable of storing at least a part of the terminal device, the part including the first recess. The locker is formed to be engageable with the first recess of the terminal device, and the locker being engaged with the first recess, which is stored in the second recess, of the terminal device to hold the terminal device.

Abstract: The invention relates to systems and methods of selecting and placing real-world wagers responsive to one or more wager triggers, obtaining outcomes of the real-world wagers, facilitating user interactions with various interactive media, and revealing the outcomes of the real-world wagers through the interactive media to give an appearance that the outcomes of the real-world wagers resulted from the user interactions even though the outcomes resulted from the real-world wagers and were determined before the user interactions. A real-world wager may be initiated by one or more wager triggers that cause the real-world wager to be placed. The one or more wager triggers may include, without limitation, acquisition of a token, user selection or initiation of interactive media (e.g., selection of a game to play), an occurrence of an event in the interactive media (e.g., based on a user controlled or other in-game action), and/or other events.

Abstract: The present invention provides a solution formulation for inhalation comprising: a liquid phase; an active ingredient containing a carboxylic ester in which the oxygen atom is covalently bound to a quaternary nitrogen-containing heterocycle, dissolved in the liquid phase; and a magnesium or calcium salt, dissolved in the liquid phase. The formulation is particularly suited to pMDIs and nebulisers.

Abstract: The invention relates to a wiper blade (10) for the cleaning of vehicle windows, with a wiper blade body (12), which is able to be connected to a wiper arm (1) via preferably a wiper blade adapter (11) arranged approximately centrally on the wiper blade body (12), wherein the wiper blade body (12) has a wiper rubber (13) with a wiper lip (14), and wherein a receiving groove (16, 17) which is U-shaped in cross section is formed and in which a strip-shaped spring strip (18, 19) engages in the wiper rubber (13) on both longitudinal sides lying opposite each other. According to the invention, it is provided that the two spring strips (18, 19) are rigidly connected to each other by means of at least one reinforcing element (25), wherein the reinforcing element (25) engages over the wiper blade body (12) on the side facing away from the wiper lip (14) and is connected at least indirectly to the two spring strips (18, 19).

Abstract: The invention relates to a transparent optical component having a cellular structure, comprising a network of walls (106), that forms a set of cells (104) that are juxtaposed parallel to a component surface. In order to produce such a component, an irregular set of points (101, 105) in the surface of the component is determined, each point being used to form a center of one of the cells. A position and an orientation of each wall are then determined such that the set of cells forms a Voronoï partition of the surface of the component. The component has a level of transparency that is compatible with an optical or ophthalmological use.

Abstract: A lamp for a compartment of a vehicle includes: a base, a mounting plate disposed on the base and having a power source receiving part, a power source received in the power source receiving part, and a lamping source disposed on the mounting plate and having a luminous region of a sector shape. The power source receiving part is located at a side of the lamping source.

Abstract: The present invention relates to a method for analyzing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.

Abstract: Apparatus and method for a modified, balanced throughput data-path architecture is given for efficiently implementing the digital signal processing algorithms of filtering, convolution and correlation in computer hardware, in which both data and coefficient buffers can be implemented as sliding windows. This architecture uses a multiplexer and a data path branch from the Address Generator unit to the multiply-accumulate execution unit. By selecting between the data path of Address Generator to execution unit and the data path of register to execution unit, the unbalanced throughput and multiply-accumulate bubble cycles caused by misaligned addressing on coefficients can be overcome. The modified balanced throughput data-path architecture can achieve a high multiply-accumulate operation rate per cycle in implementing digital signal processing algorithms.

Abstract: An electronic device may include a switching converter configured to convert an input voltage to an output voltage, and being selectively operable in a pulse skipping mode based upon a control signal. The switching converter may include a comparator having a first input configured to receive an error signal, a second input configured to receive a skipping mode reference signal, and an output configured to generate the control signal. A reference generator may be configured to generate the skipping mode reference signal as a function of a difference between the output voltage and the input voltage.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.

Abstract: A combination fishing pole holder and cleat has a bezel portion for affixing to a surface. The bezel portion has a first hole for accepting an object and a shaped indentation to accept and fit a cleat portion. The bezel portion has a pair of studs, each having a cavity formed there within. The cleat portion is shaped to fit within the shaped indentation and has a second hole, also for accepting the object. A pair of legs extends from the cleat portion and through respective studs. Each of the legs is terminated by a device/end that is wider than the cavity of the studs. A tubular portion extends from a side of the bezel and is aligned with both the first hole and the second hole for insertion of the object. The cleat portion moves between a retracted position and an extended position.

Abstract: A motor vehicle for use in chauffeur operation, in particular a taxi or a limousine, has at least one driver's seat, at least one foot pedal and at least two front wheels. In order to design a vehicle to meet the specific requirements of short-distance chauffeur operation, the driver's seat is arranged between the front wheels in such a way that the foot pedal is positioned, viewed in the driving direction, between the axles, preferably in front of the front wheel axle.

Abstract: A cantilevered rotatable carcass carrier includes a main carcass and two secondary carcasses. The two secondary carcasses are pivotally connected to two sides of the main carcass through two first cantilevers. The secondary carcasses are further pivotally connected with second cantilevers. The secondary carcasses further pivotally connected with an airtight cabin through the second cantilevers. By turning the secondary carcasses, the airtight cabin can be located under the main carcass to form a submarine mode or located above the main carcass to form a watch mode, broadening the recreation space on the water, such that the recreation space on the water is not limited to the type of two-dimensional space on the water. The present invention provides a novel water recreational carrier for the demands of different situations.

Abstract: Computational techniques for mapping a continuous variable objective function into a discrete variable objective function problem that facilitate determining a solution of the problem via a quantum processor are described. The modified objective function is solved by minimizing the cost of the mapping via an iterative search algorithm.

Abstract: Described are genes and chimeric genes encoding anti-microbial peptides. These genes can be used to generate transgenic plants with an improved resistance to, for example, plant pathogenic fungi. Alternatively, the peptides encoded by these genes can be applied as agrochemical formulations to plants suffering from microbial diseases such as fungal diseases.

Abstract: Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.

Abstract: The present invention provides a dry mixture in particulate form containing a gas release agent, a flavour component and a hydrocolloid. Upon dissolution in water, gas bubbles are released into the continuous liquid phase, and these bubbles remain dispersed in the continuous liquid phase. These dry mixes can be used for preparation of liquid food products or beverages.