Abstract: A roof anchor comprises a pliable member including an interconnecting portion interconnecting a first portion and a second portion. The first portion and the second portion each include a securing portion with a plurality of apertures and a connecting portion with an aperture. A first notch and a second notch are proximate the junctures of each securing portion and connecting portion. The first notch and the second notch extend inward from opposing sides and toward proximate a middle of the respective first and second portions, and an aperture is between each first notch and second notch.

Abstract: A method for blocking an optical lens (100) on a holding unit (200) thanks to a thermoplastic material layer (310) comprising the steps of: a) providing around the holding unit (200) a removable part (500) comprising an upper part surface (510) which is arranged so as to extend the upper assembling surface (210) of the holding unit and not to contact the bottom lens surface (120); b) providing a predetermined volume of a thermoplastic material; c) orientating the lens (100) in a desired spatial configuration; d) positioning the lens (100) contacting the thermoplastic material of step b) at a soften or melted state and pressing the lens (100) so as to keep the lens spatial configuration constant and to let the thermoplastic material flow from the upper assembling surface (210) of the holding unit to at least a part of the upper part surface (510) of the removable part (500); e) removing the removable part.

Abstract: A driver circuit includes a high-side power transistor having a source-drain path coupled between a first node and a second node and a low-side power transistor having a source-drain path coupled between the second node and a third node. A high-side drive circuit, having an input configured to receive a drive signal, includes an output configured to drive a control terminal of said high-side power transistor. The high-side drive circuit is configured to operate as a capacitive driver. A low-side drive circuit, having an input configured to receive a complement drive signal, includes an output configured to drive a control terminal of said low-side power transistor. The low-side drive circuit is configured to operate as a level-shifting driver.

Abstract: Sex hormone-binding globulin and/or any fragment thereof for use as a medicament, in particular for use in the treatment of obesity and hepatic steatosis. The invention also relates to the cosmetic use of the sex hormone-binding globulin and/or any fragment thereof for improving the bodily appearance of a mammal with subcutaneous fat herniated or accumulated within the fibrous connective tissue under the skin, in particular the cosmetic use is for cellulite.

Abstract: Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.

Abstract: Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative activity for a variety of human tumor cell lines, and is useful for treating cancers, especially solid tumors such gastric cancer, lung cancer, liver cancer, breast cancer, colon cancer, prostatic cancer, and oral cancer.

Abstract: The present invention relates to alkoxyamines of general formula (I), and to compounds of general formula (IIa), (IIb), (IIc), (IId), IIe), (IIf) or (IIg), as such and for the treatment of cancers.

Abstract: An aqueous composition comprising basic aluminium chloride salt, water soluble calcium salt, and amino acid, characterised in that the basic aluminium chloride salt is of formula AI2OH4.4CI1.6 to AI2OH4.9CI1.1 and methods for making such compositions having enhanced antiperspirancy performance.

Abstract: The present invention relates to a wiping system (1; 1?) for a glazed vehicle surface comprising a wiper (2) having a wiper blade (4) provided with at least one channel (6) in which a washing fluid (7) is intended to circulate, said channel (6) extending along the longitudinal axis (L) of the wiper blade (4) and emerging laterally from the wiper blade (4) through at least one spraying orifice (8), and a connector (3; 3?) linked to the wiper (2) and intended to be linked to a wiper arm of a vehicle, characterized in that the connector (3; 3?) has at least one opening (15; 16) formed facing at least one spraying orifice (8) of the wiper blade (4). The present invention relates also to a method for manufacturing a wiping system.

Abstract: A method of producing form-specific anti-peptide antibodies for a wild type protein and its one amino acid mutated protein using a peptide antigen, by obtaining a protein sequence of the wild type protein and its one amino acid mutated protein, selecting a continuous amino acid sequence without any internal cysteine residues that includes the one amino acid mutated sequence and wild type sequence corresponding to the mutated site at the end of the sequence to obtain a synthetic mutation peptide and a synthetic wild type peptide, conjugating the synthetic peptides to a carrier protein, and immunizing an animal to produce antibodies. Methods of detecting cancer and methods of treating cancer.

Abstract: A method includes receiving, from a user device, a first signal, the first signal including an authorization indicator associated with a social network system profile of a first user. A second signal is sent, the second signal including a first request for social network information associated with the first user. The first request is based at least in part on the authorization indicator. A third signal is received, the third signal including social network information associated with the first user. The method further includes receiving, from a second user, a fourth signal, the fourth signal including a second request for social network information associated with the first user. One or more metrics is defined, based at least in part on the social network information associated with the first user. A fifth signal is sent, the fifth signal sent such that a visual element based at least in part on the one or more metrics is displayed at an output device.

Abstract: A driving apparatus configured to drive a light emitting device includes a driving current source module operable to supply current to the light emitting device via a node during operation. A protection module coupled to the node and the driving current source module selectively injects current to the node during operation. The driving current source module is controlled based on a detection result of a voltage on the node.

Abstract: A device for moving one or more vehicle-mounted objects and a vehicle having the same are provided. The device comprises: a housing; a cover; at least one pivot for adjusting the cover, the at least one pivot disposed in the housing and comprises a first end and a second end, wherein the first end of the at least one pivot is coupled with the cover; and a box assembly disposed in the housing, the box assembly being movable between a first position away from the opening and a second position near the opening. The box assembly is coupled with the second end of the at least one pivot, wherein the cover exposes at least a part of the opening when the box assembly is at the second position, and wherein the cover covers at least a part of the opening when the box assembly is at the first position.

Abstract: An adjustable gas valve having an annular body with an inner surface defining a gas chamber and first and second annular end surfaces defining first and second openings of said gas chamber, the gas valve further having outer surface and at least one gas channel extending between the inner surface and the outer surface providing a gas communication path from the outer surface to the gas chamber, wherein said at least one gas channel is orientated to direct fluid egressing from the channel into the chamber along the inner surface. The invention further includes a regulator occupying a portion of the chamber to define a chamber operating volume, the regulator having at least one outer diameter corresponding to an inner diameter of the passage to substantially inhibit gas flow from the pass through the second opening.

Abstract: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.

Abstract: The invention relates to a method for simultaneously analyzing at least two samples using a chromatography device comprising a chromatography column having an inlet and an outlet, and at least one detector placed at the outlet of the chromatography column, the method comprising steps of: injecting fractions of each independent sample at the inlet of the chromatography column, the fractions of each independent sample being injected according to a specific injection timing sequence derived from a pseudo-random binary sequence associated with said independent sample; recording a signal generated by said detector for a period of time at least equal to a duration of the longest of the specific injection timing sequences; cross-correlating the recorded signal and a derived correlation function, said derived correlation function being derived from the pseudo-random binary sequence associated with one of the independent samples, so as to obtain an individual correlogram signal specific to said independent sample; and

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: A product obtained by solid-phase sintering of a silicon carbide powder and of a sintering additive, the product having a relative density of greater than 98.5% and including: more than 92% by weight of SiC present in the form of grains, less than 2% by weight of elemental oxygen, less than 6% by weight, in total, of other elements, wherein more than 10% by number of the SiC grains, on the basis of the total number of the grains, have an elongation factor F of greater than 3 (F>3), wherein more than 50% by number of the grains, the elongation factor F of which is greater than 3, have a width of greater than 3 micrometers, and wherein the other SiC grains in the product have a mean equivalent diameter of greater than 1 micrometer and less than 20 micrometers.