Abstract: A method for providing a personalized optical system for a wearer wherein the optical system characterizes a spectacle ophthalmic lens comprising the following steps: a) providing a visual performance level (VPL) value of at least one eye of the wearer; b) providing a set of rules linking at least the visual performance level of step a) with at least one optical criterion chosen among one or both of the two following optical criteria groups consisting of central vision optical criterion (CVOC) group and peripheral vision optical criterion (PVOC) group; c) calculating the physical and geometrical parameters of the personalized optical system or selecting the personalized optical system in an optical systems data base comprising a plurality of optical systems, so that to meet the set of rules of step b) according to the visual performance level data provided in step a).

Abstract: Examples are disclosed that facilitate provisioning of a toll system communication device used in an electronic toll collection system, such as EZ Pass. The toll system communication device (e.g., an EZ Pass tag) can have user credentials provided to it that are associated with a user payment account. As a user travels a toll road, the toll system communication device is interrogated at a toll booth location. In response to the interrogation, the toll system communication device provides information identifying the toll system communication device and associated user credentials. The user credentials may be obtained from or authenticated with a mobile device within close proximity to the vehicle equipped with the toll system communication device. Using the user credentials and the identifying information, a user payment account may be provisioned to pay tolls accrued by the vehicle using the toll road.

Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes (HBB, HBD, HBE1, HBG1 or HBG2). Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes. Methods for modulating expression of hemoglobin genes using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of hemoglobin genes.

Abstract: A process for the preparation of methanol having the process a carbon oxides per-pass conversion equal to or higher than 65%, and a selectivity to methanol formation equal to or higher than 75% by submitting carbon dioxide, carbon monoxide or a mixture of carbon monoxide and carbon dioxide to a hydrogenation reaction using a specific metal compound and specific reaction conditions of temperature, pressure, space velocity and a specific range of molar ratio of hydrogen to carbon dioxide, of hydrogen to carbon monoxide, or of hydrogen to the mixture of carbon monoxide and carbon dioxide. It further relates to a process for converting the methanol obtained into dimethyl ether or into a mixture of (C2-C8)alkene and (C1-C8)alkane.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: The present invention is to provide a smart socket, which includes a timing unit for obtaining current time; a power receiving/output unit for receiving electricity from an external power supply or outputting electricity to a power storage device; an electricity quantity monitoring unit for detecting power value of electricity received from the power receiving/output unit; a home appliance power supply unit and an electricity selling power supply unit for transmitting electricity to an electronic device and an electricity purchaser circuit, respectively; a switching unit connected to the electricity quantity monitoring unit, home appliance power supply unit and electricity selling power supply unit, and being set with a home appliance mode, a power storage mode and an electricity selling mode; and a processing unit connected to the timing unit, electricity quantity monitoring unit and switching unit for switching mode of the switching unit according to the current time and power value.

Abstract: Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided.

Abstract: Methods and devices are disclosed for providing audible, visual, and tactile alerts detectable by first responders in a geographic region impacted by a mass casualty event, such as a natural disaster or a terrorist attack. In certain aspects, an electronic device of an individual trapped within a damaged structure may establish wireless communications with a mobile cellular site and may receive a request to generate an alert audible to first responders. In response to the request, the electronic device may identify first device settings corresponding to the audible alert, and generate the audible alert in accordance with the obtained first device settings. In certain aspects, the audible alert may enable first responders to identify locations of victims trapped within structures damaged by the mass casualty event.

Abstract: A valve comprises a support including an exhaust gas passage opening, a plug able to move by tilting between a plugging position and a release position of the passage opening, and an elastic strip for returning the plug to its plugging position. The elastic strip has a first end fastened to the support and a second end bearing on the plug. The second end is able to slide on the plug between a first position, in which the plug is in the plugging position, and a second position, in which the plug is in the release position. The plug includes a stop forming a hard spot that cooperates with the second end of the elastic strip when the elastic strip is in the first position, so that this stop forms an obstacle for movement of the second end of the elastic strip from the first position to the second position.

Abstract: An amplifier circuit includes an input terminal and an output terminal. A current sinking transistor includes a first conduction terminal coupled to the output terminal and a second conduction terminal coupled to a reference supply node. A voltage sensing circuit has a first input coupled to the input terminal and a second input coupled to the output terminal. An output of the voltage sensing circuit is coupled to the control terminal of the current sinking transistor. The voltage sensing circuit functions to sense a rise in the voltage at the output terminal which exceeds the voltage at the input terminal, and respond thereto by activating the current sinking transistor.

Abstract: A method for transmitting data between a terminal and a gateway, the data being transported by Ethernet frames comprising an Ethernet header and a payload, which are themselves encapsulated in lower level packets each comprising a header containing a medium access address, comprises the following steps: determining contexts common to frames whose Ethernet headers have identical fields, and defining an identifier of each the context; associating all or some of the frames with the corresponding context identifiers and suppressing the fields from their Ethernet headers; and introducing the context identifier of each frame for which the fields of the Ethernet header have been suppressed from the header of the lower level packet encapsulating it by replacing its medium access address. A method for receiving data transmitted by means of such a method.

Abstract: The invention relates to the identification of aprataxin (APTX) expression levels as a marker for the response to topoisomerase I inhibitor-based therapies in patients with cancer and, more particularly, colon cancer. The invention also relates to methods for treating patients with cancer who have low APTX expression levels by means of administering a topoisomerase I inhibitor to said patients.

Abstract: A negative active material, a method for preparing the negative active material and a lithium ion battery comprising the same are provided. The negative active material may comprise: a core, an intermediate layer consisting of a first material and an outmost layer consisting of a second material, which is coated on a surface of the intermediate layer. The first material may be at least one selected from the group consisting of the elements that form alloys with lithium, and the second material may be at least one selected from the group consisting of transition metal oxides, transition metal nitrides and transition metal sulfides.

Abstract: The invention relates to antibodies binding to the proteins forming adrenomedullin receptors, and to the uses thereof as a drug.

Abstract: A method for identifying transmitters by a terminal in a single-frequency network comprising a plurality of transmitters. The transmitters are synchronized and transmit with an artificial delay ?i, specific to each transmitter. The method comprises at least one step of acquiring the approximate position of the terminal {circumflex over (p)}, the position pi of a list of transmitters {Tx} in the vicinity of the terminal and the delays ?i associated with them, a step of measuring pseudo-distances ?i between the transmitters and the terminal and a step of associating the measurements ?i with the transmitters of known positions pi by minimizing a cost function, said cost function ?(?i,{circumflex over (p)},?) corresponding to the norm of the error between the measurements ?i and a model of measurements of the pseudo-distances applied to a permutation of the position of the transmitters ?.

Abstract: A window assembly is used in a vehicle. The window assembly comprises a transparent pane having an inner surface and an outer surface spaced from the inner surface. The window assembly also comprises a ceramic frit disposed on a portion of the transparent pane. A primer is disposed on at least one of the transparent pane and the ceramic frit for providing a bonding surface. An encapsulation is coupled to the primer.

Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.

Abstract: A method for recovering a clock frequency of a CAN bus, the method including: receiving a data signal, wherein the data signal includes at least one state transition; detecting the state transition; and adjusting a frequency of a clocking signal generated by an oscillator circuit, wherein the frequency is adjusted when the state transition is detected and adjusting the frequency is for recovering the clock frequency of the CAN bus.

Abstract: Rate-controlled particles, comprising compounds of the formula as a solid dispersion.