Abstract: The invention provides crystalline hydrochloride salts of (S)-3-[(S)-2-methanesulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine. This invention also provides pharmaceutical compositions comprising the crystalline salts, processes and intermediates for preparing the crystalline salts, and methods of using the crystalline salts to treat diseases.

Abstract: A polarity-switching amplifier circuit includes: a first amplifying transistor and a second amplifying transistor, a transformer which includes a primary winding and a secondary winding, and a polarity-switching controller. An unbalanced input signal is input to the first amplifying transistor and the second amplifying transistor. The transformer receives an output signal of the first amplifying transistor and an output signal of the second amplifying transistor as a balanced signal input to the primary winding, and outputs a signal from the secondary winding. The polarity-switching controller turns on one of the first amplifying transistor and the second amplifying transistor and turns off the other thereof.

Abstract: Process for manufacturing edible fat continuous emulsions comprising 10 to 85 wt. % of a dispersed water-phase and 15 to 90 wt. % of total fat, said process comprising the steps of: a. providing a water-phase; b. providing liquid oil; c. providing fat powder comprising hardstock fat; d. providing hardstock fat in liquid form; e. mixing fat powder comprising hardstock fat, hardstock fat in liquid form and liquid oil to provide an oil-slurry; f. mixing the oil-slurry provided at step ‘e’ with the water-phase to provide a water-in-oil emulsion, wherein the fat powder is not subjected to temperatures at which a substantial part of the fat powder melts. An edible fat continuous emulsion comprising 10 to 85 wt. % of a dispersed water-phase and 15 to 90 wt. % of total fat, comprising at least 2 wt. %, based on the weight of total fat, of a first hardstock fat with the following solid fat profile: N20 from 65 to 95; N35 from 25 to 55; and further comprising at least 2 wt.

Abstract: A new variety of Miniature rose suitable for garden decoration, having flowers of black purple coloration with a white eyezone.

Abstract: A coloured laundry detergent is provided that brightens on exposure to light.

Abstract: A method for cutting-out a multi-layer ophthalmic lens (100) following a desired contour (C3), includes: a step of pre-blanking the ophthalmic lens (100) using a preliminary tool (210; 223), according to a preliminary contour (C1, C1?); a step of blanking the ophthalmic lens (100) using a blanking wheel (210), following a blanking contour (C2, C3); and a step of finishing the ophthalmic lens (100) using a finishing tool (212). According to the invention, the preliminary contour (C1, C1?) is larger than the desired contour (C3), and the blanking wheel (210) used has a granulometry of between 0.1 and 0.5 mm and is controlled in relation to the ophthalmic lens (100) so as to apply a radial force of between 0.1 and 5 N to the ophthalmic lens (100) during the blanking step.

Abstract: The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.

Abstract: A method includes identifying a plurality of network components in a network topology of a data transmission network, identifying data transmission performance patterns based on at least one key performance indicator (KPI) for each of the plurality of network components, identifying at least one data transmission issue in the network, and identifying a model degraded performance pattern associated with the at least one data transmission issue. The method may also include matching the model degraded performance pattern to the data transmission performance patterns to form matched performance patterns, and identifying a root-cause component from the network components based on the matched performance pattern.

Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of a target gene. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of a target gene. Methods for modulating expression of a target gene using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of a target gene.

Abstract: A cleaning apparatus is described and which includes a chassis for enclosing an electrically energizable vacuum motor; fluid pump; and first and second electrical heaters, and which when individually energized consume a given amount of electricity; and an electrical control coupled in controlling relation relative to the respective vacuum motor, fluid pump and first and second electrical heaters, and wherein the electrical control has first, second and third modes of operation; and wherein during the respective modes of operation the respective vacuum motor; fluid pump; and first and second electrical heaters are selectively energized in a predetermined manner such that the cleaning apparatus consumes less than about 20 amps of electrical power.

Abstract: A process of straightening the hair comprising the following consecutive steps: i) applying to dry hair a hair treatment composition having a pH of 3 or less at 20° C. and comprising at least 4 wt % of the total composition of a bidentate or tridentate carboxylic acid; ii) leaving the product o the hair for at least 5 minutes; iii) rinsing the product from the hair; and iv) combing.

Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.

Abstract: The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer from said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease. The therapeutic potential of said antibodies is based on observing that the inhibition of LIF can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation.

Abstract: A door to door sales management tool utilizes a mobile device configured to request data from a database regarding a neighborhood within proximity of that sale. The mobile device sends results back to the database, wherein the results are flagged as verified. A simplified prequalification system is shown where a salesperson may select a house on a map to run a prequalification on the residents expected occupants of the selected house.

Abstract: A system for anchoring a guitar string comprising a guitar top, a bridge fixed to the guitar top, and at least one aperture extending through the bridge and top for receiving an end of a string with a ball attached thereto. A bridge pin has a body that is insertable into the aperture. The body has two spaced-apart legs forming a space therebetween wide enough to accommodate the string but not the ball. A rear side of the legs has matching anchoring surfaces that are constructed and arranged to receive and retain the ball when the string is in tension.

Abstract: The present invention relates to an infusion packet (51) comprising a top (52), a bottom (53), a first side (54) and a second side (55); wherein the bottom (53) of the packet is defined by a gusset (61) and each side (54, 55) of the packet is defined by a seal that extends between the top (52) and bottom (53) of the packet; the packet (51) being characterised in that the seals defining the sides (54, 55) are arranged such that the packet has a compartment with a substantially trapezoidal cross-section.

Abstract: An approach for predicting potential reliability or performance issues associated with a product and presenting various options to address those potential issues includes determining one or more parameters associated with a transaction related to a product. The approach also includes obtaining, in response to the transaction and based on the one or more parameters, a metric describing a predicted operational status of the product. Further, the approach includes initiating a presentation, based on the metric, of one or more potential actions associated with the transaction and related to the product.

Abstract: An elevator interior illumination assembly comprising a primary LED driver that provides conditioned DC power to primary and backup LEDs when AC power is available from a primary electric power source. The backup LEDs receive DC power from a backup electric power source when AC power is not available to the primary LED driver from the primary electric power source.

Abstract: The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.