Abstract: The invention relates to xanthone derivatives of formula (IA) or (IB) and their use for manufacturing a medicament for cancer, and in particular for chemotherapeutic resistant cancer. More particularly, the invention relates to compounds and compositions comprising such xanthone derivatives for the prevention and/or treatment for chronic leukemia and, for example, for chronic lymphocytic leukemia (CLL) or B-lymphoma.

Abstract: The invention relates to a filtering structure of the honeycomb type, comprising an array of longitudinal adjacent channels of mutually parallel axes separated by porous filtering walls, said structure being characterized in that the material constituting the plugs placed on the first end of the filter have substantially the same composition and are structuring continuous with said walls and in that the plugs placed on the second end of the filter have a different chemical composition and/or a different structural composition from those/that of the plugs placed on said first end.

Abstract: A tissue joining device and a surgical instrument for employing the tissue joining device are provided. The tissue joining device may be designed such that a first member may be inserted into a second member in discrete increments so that two lumen structures can properly be combined.

Abstract: Methods and therapeutics are provided for treating metabolic disorders by activation of melanocortin signaling pathways. Generally, the methods and therapeutics can induce activation of melanocortin receptor signaling to increase energy expenditure and induce weight loss. In one embodiment, a method for performing a diagnostic procedure can be chosen, energy expenditure then assess in light of the diagnostic procedure and a definitive procedure(s) can be selected dependent on the outcome of the energy assessment. In another embodiment, a diagnostic procedure can be chosen to activate melanocortin receptor pathways, energy expenditure can be assessed and a definitive procedure(s) can be chosen that selectively and optimally activate melanocortin receptor pathways.

Abstract: The invention relates to a method for measuring the performance of a network (18). The method includes steps comprising: parameterizing requests pointing to resources that can be accessed from a computer connected to the network, the parameterized requests being stored in a database; creating a user session comprising grouping together various stored requests; running a test campaign comprising concatenating in time the emission of the various requests in a session, each request being emitted by a user terminal connected to the network; for each one of the emitted requests, waiting for a response and calculating the value of at least one typical variable of the received response; and, aggregating the various values of the typical variable calculated during the test campaign to determine the value of a network performance estimator.

Abstract: In vitro method and kit for prognosis or prediction of the response of rheumatoid patients to treatment with TNF-? factor blocking agents, which comprises determining, in a blood sample from said patients, the expression level of at least one of the eight genes selected from the group: HLA-DRB3, EAT2, GNLY, CAMP, SLC2A3, IL2RB, MXD4 and TLR5 or combinations thereof and comparing said expression level to the expression values obtained from responsive and non-responsive patients who showed responsiveness to the treatment and those who showed non-responsiveness thereto.

Abstract: It is an object of the present invention to provide an efficient method for manufacturing heterocycle-substituted pyridine derivatives. The present invention provides a method for manufacturing a compound represented by the following formula (I): the method including reacting a compound represented by the following formula (III): and a compound represented by the following formula (II): in a solvent and in the presence of a palladium catalyst and a base, wherein R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group that may be protected with a protective group, etc.; one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom; Q represents a leaving group; the ring A represents a 5- or 6-member heteroaryl ring or a benzene ring, which may have one or two halogen atoms or C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, etc.

Abstract: Use of the tripeptide ITP and salts thereof for the preparation of a functional food angiotensin-converting enzyme inhibitor. Also provided is the use of the combination of tripeptide MAP and the tripeptide ITP and salts thereof as an angiotensin-converting enzyme inhibitor in functional foods.

Abstract: A package includes a first die and a second die, at least one of said first and second dies being a memory. The dies are connected to each other through an interface. The interface is configured to transport a plurality of control signals. The number of control signals is greater than a width of the interface. At least one of the first and second dies performs a configurable grouping so as to provide a plurality of groups of control signals. The signals within a group are transmitted across the interface together.

Abstract: The mixture of molten alumina-zircon grains has the following chemical composition in percentage by weight to give 100%: 40-45.5% ZrO+HfO2; 46-58% Al2O3; 0-10% additive; <0.8% SIO2 and <1,2% impurities. The mixture is characterised in that the degree of impurity-containing grains is less than 2% and the nodule concentration measured on the section of any grain of the mixture is greater than 500 nodules per mm2 in at least 50% of cases.

Abstract: Porous ceramic part comprising a porous ceramic foam having a total porosity of between 50 and 92% and an intergranular porosity of at least 5%, walls of at least some of the cells of the ceramic foam being at least partly covered with an impregnation material. The invention relates in particular to a recrystallized silicon carbide foam impregnated with silicon.

Abstract: A method of multipath error suppression in a satellite navigation receiver, including steps of navigation satellites signals searching, receiving and processing complex signals from each satellite, tracking found signals with a following-up open loop and determining coordinates, receiver velocity and exact time based on measurements of direct and reflected signal delay and Doppler frequency, the method including: forming, on the basis of navigation parameters, a two-dimensional accumulated power grid, calculating single-path signal corrections using the centered accumulated power grid determining, whether a multipath is presented, and performing, in case of positive result of this determination, improvement of corrections using weights, wherein, performing improvement of corrections using weights is carried out by forming a likelihood function on the basis of a centered accumulated powers vector, and correction is performed according to the found likelihood function global maximum.

Abstract: A current interrupting chamber comprising a moving assembly movable axially between a start position and an end position of an operation of opening the circuit-breaker. The current interrupting chamber includes a first compression chamber; a hollow drive tube having ports for bringing the interior of the drive tube into communication with the outside of the current interrupting chamber; a second compression chamber; and a structure for obstructing the ports of the drive tube from the start position of an operation of opening the circuit-breaker and up to an intermediate position which is reached between the position of separation of two arcing contacts from each other and the end position of an operation of opening the circuit-breaker.

Abstract: A method of multi-path searching in a cellular network is provided. The method carries out a correlation process over a predetermined integration period in relation to a first pilot signal received in connection with a first cell of the cellular network to generate first multiple correlation measurements corresponding to a plurality of time delays in the signal, analyzing the first multiple correlation measurements in relation to the time delays to identify multi-path positions in the signal. Information of the multi-path positions over a first predetermined integration period is stored as a first set of candidate multi-path positions and compared with a second set of candidate multi-path positions derived from second multiple correlation measurements corresponding to the time delays over a second predetermined integration period in relation to the first pilot signal, so as to confirm or reject candidate multi-path positions and define modified candidate multi-path positions.

Abstract: A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M??(I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.

Abstract: A high or very high voltage circuit breaker comprising, for each phase: at least two breaker chambers connected electrically in series and disposed parallel to each other in a metal tank, in which the ends of the chambers through which at least one pair of movable contacts of each chamber is driven lie in a common plane; and the mechanical transmission assembly whereby simultaneous movement is transmitted, and which ensures identical stroke lengths for the movements of the movable contacts of at least two chambers, comprises firstly at least two bars of identical lengths, each coupled to the pair of movable contacts of one of the chambers, and secondly, drive means coupled to at least one drive rod outside the tank or passing through its wall.

Abstract: Use of a high shear mechanical device incorporated into a process for the production of sulfolene as a reactor device is capable of decreasing mass transfer limitations, thereby enhancing the sulfolene production process. A system for the production of sulfolene from butadiene and sulfur dioxide, the system comprising a reactor and an external high shear mixer the outlet of which is fluidly connected to the inlet of the reactor; the high shear mixer capable of providing a dispersion of sulfur dioxide gas bubbles within a liquid, the bubbles having an average bubble diameter of less than about 100 ?m.

Abstract: Provided herein is a suitable method for detecting the presence or absence of a cancer in an individual, by determining the level of methylation of the sense strand of a selected regulatory region of a tumor suppressor gene. Also provided herein is a method of detecting the presence or absence a cancer in an individual by determining if there is an apparent 100% methylation by assay of the CpG sites in the anti-sense strand of a selected regulatory region of a tumor suppressor gene. Also provided herein is a method of tissue typing by determining the level of methylation of the anti-sense strand of a selected regulatory region of a tumor suppressor gene indicating an enhanced likelihood that a tissue is liver.

Abstract: A bin assembly that includes a bin housing and a bin that is pivotal between an open and a closed position within the bin housing. The bin housing includes a forward bulkhead panel, aft bulkhead panel and an aft housing panel that includes a rigid valence panel having one of a latch striker or a latch assembly secured thereto. The rigid valence panel has opposite ends that are secured to the forward and aft bulkhead panels. The bin includes an aft wall, a forward wall, a bin bottom and the other of a latch striker or a latch assembly secured to the bin bottom, thereby defining a latching location. A downward load in the bin is distributed from the latching location, along the rigid valence panel and to the aft and forward bulkhead panels.