Abstract: Disclosed is an instrument including a multipath, monolithic optical component, made up of a portion of a transparent material between two opposite faces of the component. One of the two faces of the component is formed by a first refracting surface, and the other face includes several second refracting surfaces which are juxtaposed. Each optical path of the component is formed by one of the second refracting surfaces in combination with a corresponding portion of the first refracting surface. One such component is suited for being part, within the instrument, of a detection module with multiple optical paths arranged in parallel, with a matrix photodetector shared by the optical paths. Such a detection module may be compact enough in order to be integrated into a cryostat cold screen, improving cooling thereof, and may be combined with an objective in order to form an instrument with multiple optical paths.

Abstract: Provided herein is a crystalline hydrate of the compound of formula 1: Also provides herein are pharmaceutical compositions comprising such crystalline hydrate, methods of using such crystalline hydrate to treat respiratory diseases, and processes useful for preparing such crystalline hydrate.

Abstract: A degradable containment includes an outer structural layer constructed of a pulp material, a central carrier layer constructed of a biopolymer, and an interior nanomaterial layer constructed of a nanomaterial.

Abstract: A user interface (UI), data structures and algorithms facilitate programming, analyzing, debugging, embedding, and/or modifying problems that are embedded or to be embedded on an analog processor (e.g., quantum processor), increasing computational efficiency and/or accuracy of problem solutions. The UI provides graph representations (e.g., source graph, target graph and correspondence therebetween) with nodes and edges which may map to hardware components (e.g., qubits, couplers) of the analog processor. Characteristics of solutions are advantageously represented spatially associated (e.g., overlaid or nested) with characteristics of a problem. Characteristics (e.g., bias state) may be represented by color, pattern, values, icons. Issues (e.g., broken chains) may be detected and alerts provided.

Abstract: The present disclosure relates to the treatment of dilated cardiomyopathies, in particular to 5 the use of an inhibitor of CILP-1.

Abstract: A radiofrequency antenna is adapted to be mounted on a spacecraft. The radiofrequency antenna includes four helical strands of a super elastic shape memory alloy and is configured to move from a deployed configuration to a constrained stacking configuration and to return autonomously to the deployed configuration.

Abstract: A variegator and a process for using it. The variegator permits the manufacturer to obtain desirable patterns of distribution of sauce and chunks in frozen confections while at the same time permitting fast cleaning-in-place times to minimize factory downtime. The variegator comprises a) one or more conduits, each suitable for feeding a base frozen confection to a first opening or set of openings into a chamber, b) one or more conduits suitable for feeding a fluid variegating material such as a sauce through a second openings or set of openings at a level below the first set into the chamber below the base frozen confection opening, and c) a static mixer below the variegating material opening, the static mixer comprising at least two baffles.

Abstract: The application relates to a shaped detergent product comprising 10-100 wt. % of a solid amorphous phase and 0-90 wt. % of one or more other solid phases, wherein the solid amorphous phase comprises 25-88 wt. % free acid equivalent of aminopolycarboxylate, 10-60 wt. % free acid equivalent of an acid, wherein the acid is not an aminopolycarboxylate, 2-30 wt. % water, and wherein the shaped detergent product contains at least 0.5 wt. % surfactant.

Abstract: A bushing includes a body that is cylindrical; a bore through the body; a channel extending along an inner face of the bore; and a groove on a substantially planar surface of the bushing and including a first end intersecting with an end of the channel and a second end extending radially from the bore.

Abstract: A method and a system for determining the amount of oxygen required by a user with respiratory problems are disclosed. First data about several users with respiratory problems is stored in a database. The method a) collects second data from a monitored user while (s)he is performing a test at a first location; b) computes a user’s behavioral model executing a first algorithm on the first and second data; c) collects, every period of time t1, third data of the user while (s)he is performing an activity at a second location; d) adjusts, every period of time t2, the computed user’s behavioral model using the first algorithm, providing a customized user’s behavioral model as a result; and e) computes an estimator of the quantity of oxygen to be delivered to the user by executing a second algorithm on the customized user’s behavioral model.

Abstract: An adhesive composition comprises about 2.5 to about 12% by weight of a biodegradable polymer; about 0.5 to about 1.5% by weight of a preservative; and at least 10% by weight of water.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth regardation disorders, such as achondroplasia.

Abstract: The present invention proposes a rescue system and method for man overboard with remote monitoring, which is implemented by a rescue system consisted of an onboard processing unit, a distress signal module, an unmanned rescue vehicle, an autonomous ship, a communication module, and a shore control center (SCC). The technical effect of the present invention is that when a person falls into the water, the unmanned rescue vehicle can automatically locate and monitor the falling target immediately, and the shore control center (SCC) can accurately locate the relative position between the unmanned rescue vehicle and the ship where the person falls. Thereby, the shore control center (SCC) can control the rescue process throughout the entire process and release rescue device for rescue.

Abstract: A solid nanocomposite electrolyte material comprising a mesoporous dielectric material comprising a plurality of interconnected pores and an electrolyte layer covering inner surfaces of the mesoporous dielectric material. The electrolyte layer comprises: a first layer comprising a first dipolar compound or a first ionic compound, the first dipolar or ionic compound comprising a first pole of a first polarity and a second pole of a second polarity opposite to the first polarity, wherein the first layer is adsorbed on the inner surfaces with the first pole facing the inner surfaces; and a second layer covering the first layer, the second layer comprising a second ionic compound or a salt comprising first ions of the first polarity and second ions of the second polarity, wherein the first ions of the ionic compound or salt are bound to the first layer.

Abstract: The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.

Abstract: A spoiler of an automotive wiper system that extends in a main direction of elongation and is configured to be mounted on the wiper system's arm or a wiper where the spoiler is predominantly formed by a one-piece main layer, where the spoiler includes at least one engraving zone in which the main layer has a cavity that houses at least one secondary layer that is distinct from the main layer and the engraving zone is configured in such a way that the at least one secondary layer is elongated while being at least partially covered by the main layer.

Abstract: The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

Abstract: The invention concerns a wiper blade for a vehicle, comprising at least one wiper strip intended to come to bear on a glazed surface and at least one bending member (1) housed in a support, the wiper strip being held by the support, the bending member (1) being configured to generate curvature in the wiper blade, the bending member (1) being arranged in the form of a longitudinally extending strip, the strip comprising, seen in cross-section, an intermediate portion (2) arranged between two lateral portions (3a, 3b) of the strip, characterized in that a first thickness (12) of the intermediate portion (2) is less than a second thickness (13) of at least one of the lateral portions (3a, 3b).

Abstract: A management server enables a user to make a dish on a selected date and time and a selected space designated by a company. A user information management unit manages user information including confirmation information and profile information; a company information management unit manages company information including information regarding a space; a recipe determination unit determines a recipe of the dish on the basis of the user information and the company information; an ordering unit orders at least one of an ingredient and a seasoning for making the dish on the basis of the recipe; and a content management unit manages content related to the recipe to be provided to the user. The confirmation information of the user indicates the selected space and the selected date and time, and the information regarding the designated space includes constraint information regarding use of the space.

Abstract: The present invention relates about a wiper system for cleaning a vehicle window, comprising a drive attachment, an arm, a wiper blade and a connecting body located between the drive attachment and the arm, the wiper system comprising a pivot link between the connecting body and the drive attachment, the wiper system comprising a rotational link between the connecting body and the arm, the rotational link having an axis that extends along a first direction, the pivot link having an axis that extends along a second direction, said first direction and said second direction being intersected, wherein the wiper system comprises a mechanical link between the drive attachment and the arm enforcing a rotation of the pivot link around the second direction upon a rotation of the arm around the first direction.