Abstract: The invention relates to the use of a recombinant porcine adeno-associated virus (AAV) vector comprising a peptide-modified porcine AAV serotype 1 (AAVpol) capsid in gene therapy of muscle and/or central nervous system (CNS) disorders, in particular neuromuscular diseases such as genetic neuromuscular diseases.

Abstract: The method for inferring epileptogenicity of a brain region not observed as recruited or not observed as not recruited, in a seizure activity of an epileptic patient brain, includes: providing a computerized model modelling various regions of a primate brain and connectivity between the regions; providing the computerized model with a model able to reproduce an epileptic seizure dynamic in the primate brain; providing structural data of the epileptic patient brain and personalizing the computerized model using the structural data to obtain a virtual epileptic patient (VEP) brain model; translating a state-space representation of the VEP brain model into a probabilistic programming language (PPL) using probabilistic state transitions to obtain a probabilistic virtual epileptic patient brain model (BVEP); and acquiring electro- or magneto-encephalographic data of the patient brain and fitting the probabilistic VEP brain model against the data to infer the epileptogenicity of the brain region that is not observe

Abstract: A system for dispensing a liquid to a user, that includes a container having a reference container volume and a wall with: a bottom portion, a side portion adjacent to the bottom portion, a shoulder portion adjacent to the side portion, a liquid, in the container, a dispenser, arranged to receive and hold the container, characterized in that: the bottom portion and the shoulder portion have a similar male shape. The dispenser includes a receiving portion having a female shape arranged to mate either with the bottom portion or with the shoulder portion, so as to stably hold the container.

Abstract: The invention concerns a device (100) for cleaning the optical surface (162) of at least one optical sensor (160) for a motor vehicle. The cleaning device (100) includes a source (110) for emitting a laser beam and means for guiding the laser beam onto at least a part of the optical surface (162) of an optical sensor (160) so as to clean it.

Abstract: Described are stabilized materials and methods and systems for providing said stabilized materials. The system includes a first unit for mixing a first combination that includes a quantity of drill cuttings and a drying agent. The system may include a second unit for mixing the first combination with at least a binder and/or a surface acting agent and providing a second combination. The second combination is formed when the first combination is caused to have a reduced moisture content, transitioning from a first state to a second state. The reduced moisture content in the second state is at least 20% less than the moisture content of the drill cuttings. The first combination in a second state is a stabilized material. The first combination in a second state may be a dried material. The binder and/or a surface acting agent with or without additional additives are not introduced until the first combination is in the second state.

Abstract: The invention relates to a method of isolating an immunoglobulin, comprising the steps of: a) providing a separation matrix comprising at least 15 mg/ml multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support, wherein the porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50,v) of 56-70 micrometers and a dry solids weight of 55-80 mg/ml; b) contacting a liquid sample comprising an immunoglobulin with the separation matrix; c) washing the separation matrix with a washing liquid; d) eluting the immunoglobulin from the separation matrix with an elution liquid; and e) cleaning the separation matrix with a cleaning liquid comprising at least 0.5 M NaOH.

Abstract: The present invention relates to a wind turbine blade and a method for its manufacture. A lower shell part and an upper shell part are provided, each shell part having a leading edge and a trailing edge. A first shear web and a second shear web for connecting an inner surface of the lower shell part with an inner surface of the upper shell part are provided. The first shear web and the second shear web are connected by a first distance member in a chordwise direction. The first distance member is arranged for accommodating a variable chordwise distance between said first shear web and said second shear web. The first shear web and the second shear web are placed in the lower shell part and the upper shell part is mounted.

Abstract: The present application relates to the field of computer software technologies, and in particular, to a face spoofing attack detection method and system. The suggested method comprises capturing an image; determining a context of the captured image; highlighting a part of the captured image to generate an image with the highlighted part, wherein the highlighted part is a potential spoofing region determined based on the context of the captured image; combining the captured image with the image with the highlighted part to generate a summarized image; performing face spoofing attack detection in the summarized image, wherein only the highlighted part has priority in the face spoofing attack detection, generating a general spoofing score as a result of the face spoofing attack detection; comparing the general spoofing score result with a threshold for face liveness detection.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention relates to a refinement of a spindle drive (1), and to a louvered window or a louvered shutter having a spindle drive for moving louver elements such that applied return forces and return torques can be absorbed better, and in particular without placing a load on the drive motor. For this purpose, the spindle drive (1) has a specially designed return stop mechanism (6) arranged between a drive shaft of a drive motor (3) and a threaded spindle (4).

Abstract: A window wall system includes a plurality of window wall modules for forming at least in part a facade of a building. Each window wall module is connected between two consecutive concrete slabs of the building and includes a bottom rail, a top rail, two vertical mullions, and a window panel. The system also includes a plurality of anchoring brackets for connecting the bottom rail of each window wall module to a respective one of the concrete slabs, and a plurality of preformed sealing membranes. Each anchoring bracket is configured to be affixed to a top surface of the respective one of the concrete slabs. Each sealing membrane sealingly engages the bottom rail of a corresponding window wall module. Each sealing membrane is interlocked with a respective one of the anchoring brackets to retain the sealing membrane in place. Each sealing membrane is made of an elastomeric material.

Abstract: A device for analysis of cells comprises: an integrated circuit arrangement on a substrate; a dielectric layer formed above the integrated circuit arrangement; a microelectrode array layer formed above the dielectric layer, said microelectrode array layer comprising a plurality of individual electrodes, wherein each electrode is connected to the integrated circuit arrangement through a via in the dielectric layer; and wherein a plurality of longitudinal trenches in the dielectric layer and the microelectrode array layer are for stimulating cell growth on a surface of the device

Abstract: Disclosed systems and methods provide automatic recognition of information from stationary and/or moving vehicles. A disclosed system includes an image capture device that captures an image of a vehicle surface and thereby generates image data. A processor circuit receives the image data from the image capture device and may process the image data to determine a Department of Transportation (DOT) number. The processor circuit may control the image capture device to capture a plurality of images, to detect and recognize text characters in each of the plurality of images, and to compare probabilities of likely DOT numbers determined from each of the plurality of images. The processor circuit may be further configured to determine DOT numbers from captured images by processing image data using a machine learning algorithm. The system may be configured to be portable and to perform real-time analysis using an application specific integrated circuit (ASIC).

Abstract: A profiled structure for an aircraft or turbomachine is elongated in a direction in which the structure has a length exposed to an airflow and includes serrations defined by successive teeth and depressions. The serrations may be transverse to a leading edge and/or a trailing edge of the profiled structure and in the direction of elongation. Along the profiled leading edge and/or profiled trailing edge, the successive teeth and depressions may extend only over a part of the length exposed to the flow. The amplitude and/or spacing of the teeth may vary monotonically except for the few teeth nearest each end of the part, with a remaining part of the length being smooth.

Abstract: The present invention relates to a valve for a spray system for spraying a washing liquid comprising a valve body, enclosing a hydraulic cavity which is configured to be fluidically connected to a hydraulic conduit of the spray system and is intended to receive the washing liquid, a mobile element which is configured to be moved in the hydraulic cavity between an open position, in which it lets the washing liquid pass into the hydraulic conduit, and a closed position, in which it blocks the passage of the washing liquid into the hydraulic conduit, characterized in that the valve also comprises at least one opening provided in the wall, said opening being closed by an elastic membrane which is configured to be deformed if the washing liquid freezes in the hydraulic cavity.

Abstract: The present invention relates to an adapter (1) for a wiper system (6), comprising at least a side wall (10) and an upper wall (12) having at least one common edge between them, the side wall (10) and the upper wall (12) helping to define an inner volume of the adapter (1), the adapter (1) comprising a first inner wall (20) and a second inner wall (66) helping to delimit, at least partially, a receiving area (26) intended to receive the connector (8), the adapter (1) comprising at least one receiving housing (32) which is intended to receive the arm and which has a rectangular cross section defined by two major sides (33) and two minor sides (31), characterized in that a straight line (D) passing through one of the major sides (33) cuts the receiving area (26) intended to receive the connector (8).

Abstract: Topical cosmetic compositions containing a 4-substituted resorcinol derivative along with N,N?-diacetyl-L-Cystine exhibit improved storage stability and oxidative stability. A method of stabilizing 4-ethyl resorcinol or 4-hexyl resorcinol in a composition comprising a cosmetically acceptable vehicle by adding to the composition N,N?-diacetyl-L-Cystine in an amount sufficient to stabilize said 4-ethyl resorcinol or 4-hexyl resorcinol.

Abstract: The present invention provides a pea isolate comprising, calculated by weight of dry matter: a. 0-10 wt.% of pea components having a molecular weight of at least 30 kDa; b. 0-70 wt.% galacto-oligosaccharides selected from raffinose, stachyose, verbascose and combinations thereof; c. 0.05-5 wt.% of 5?-inosine monophosphate (IMP); d. 0-1 wt.% of 5?-adenosine monophosphate (AMP); wherein the weight ratio IMP : AMP exceeds 1:1. This pea isolate is a valuable flavouring material that can be isolated from pea whey - an effluent stream that is produced in the manufacture of pea protein isolates - by subjecting the pea whey to ultrafiltration and/or nanofiltration, and by subjecting the pea whey or the filtration permeate to enzymatic treatment with AMP deaminase.

Abstract: The objective of the current invention is to provide a composition that can be used for making bouillons, soups and gravies, and that is free from kitchen salt. Such composition has now been developed, preferably in the form of a solid or pasty cube, for preparing a bouillon, to which no kitchen salt has been added, and which contains a specific ratio of native starch and maltodextrin and/or glucose syrup. This ratio between these ingredients leads to a good quality composition that can be prepared in the same way as regular compositions for making bouillons that do contain kitchen salt.

Abstract: A shaped detergent product comprising 10 to 100 wt. % of a first solid phase and 0 to 90 wt. % of one or more other phases, wherein the first solid phase comprises: a) non-crystalline chiral aminopolycarboxylate; b) non-crystalline organic acid other than component a); c) at most 30 wt. % water; d) at most 50 wt. % of non-crystalline water-soluble component other than component a) or component b); e) at most 20 wt. % of homogeneously dispersed crystalline material; wherein the combination of the components a), b) and c) is present in the first solid phase in a concentration of at least 35 wt. % of the total weight of the solid phase; and wherein components a), b) and c) are present in the solid phase in a ratio of from 25 to 88 parts by weight of free acid equivalent of component a): from 10 to 60 parts by weight of free acid equivalent of component b): from 2 to 30 parts by weight of component c); and wherein the shaped detergent product comprises at least 0.5 wt. % surfactant.