Abstract: Disclosed is a topical composition comprising: (i) an antimicrobial active which is at least one of piroctone, caprylhydroxamic acid, benzohydroxamic acid, or piroctone olamine; and (ii) Febrifugine. Also disclosed is a non-therapeutic method of providing topical antimicrobial benefit on a topical surface of a human or animal body comprising a step of applying a safe and effective amount of the topical composition.

Abstract: Some embodiments relate to computer implemented methods and apparatus for integrating healthcare related events and services for a customer having insurance coverage provider via a web-based platform. The method and system enables providing a link to a customer that enables the customer to access the platform so as to enter healthcare information that includes insurance information relevant to the healthcare insurance provider during an initial registration session, identifying a pharmacy that is local to the customer and accepts the customer's healthcare coverage, transmitting a communication to the customer that includes an uncovered cost due for the therapeutic or diagnostic, facilitating the payment process from the customer to the healthcare provider via a secure payment processor, and notifying the customer of the identified pharmacy.

Abstract: Disclosed is a topical composition comprising: (i) an antimicrobial active which is at least one of piroctone, caprylhydroxamic acid, benzohydroxamic acid, or piroctone olamine; and (ii) norbraylin. Also disclosed is a non-therapeutic method of providing topical antimicrobial benefit on a topical surface of a human or animal body comprising a step of applying a safe and effective amount of the topical composition.

Abstract: The current disclosure provides antibodies that bind to peptides associated with the primary immunodeficiency disorders (PIDD) Wiskott-Aldrich Syndrome (WAS) and X-linked agammaglobulinemia (XLA). The antibodies can be used in peptide immunoaffinity enrichment coupled to selected reaction monitoring mass spectrometry (immuno-SRM) assays for clinical diagnosis and newborn screening of WAS and XLA, among other uses.

Abstract: Systems, devices, and methods are disclosed for attaching two automotive components comprising different materials having different coefficients of expansion, comprising providing a flange around a perimeter of each of the components, wherein at least one component defines a plenum contiguous to the perimeter, providing corresponding inner faces of the flanges, providing a channel in at least one of the corresponding faces of the flanges, wherein the channel is coaxial to the perimeter, disposing a gasket in the channel, and surrounding the flanges with a locking ring, wherein the ring has an axial channel and a pin disposed perpendicular to the channel to secure a first end of the locking ring to a mating second end of the locking ring.

Abstract: The splitboard fastening system is for use with a splitboard having first and second splitboard skis. The splitboard fastening system includes an adjustable crossbar attachment, configured to be coupled to the first splitboard ski, and including a crossbar having an engagement interface that is adjustable relative to a center seam of the splitboard. A rotatable lever attachment is configured to be coupled to the second splitboard ski, and includes a post, defining an axis of rotation, and coupled to a lever. Wherein, in a locked configuration, the post exerts a lateral force against the engagement interface of the crossbar based upon rotation of the lever.

Abstract: Disclosed is a device including a compliant mechanism including: a first monolithic flexible element, having first and second ends defining a first longitudinal direction, arranged such that it is able to be subjected to an elastic deformation involving a relative movement between its first and second ends; and at least a second monolithic flexible element, having first and second ends defining a second longitudinal direction distinct from the first longitudinal direction, arranged such that it is able to be subjected to an elastic deformation involving a relative movement between its first and second ends. At least one of the first and second monolithic flexible elements includes at least one opening located between its first and second ends and defining a passage for a portion of the other monolithic flexible element such that the first and second monolithic flexible elements are interlocked.

Abstract: Methods that include providing and reacting a solid support and an alkali-stable ligand derived from an immunoglobulin-binding bacterial protein to form a separation matrix having covalently coupled alkali-stable ligands; and washing with a wash solution comprising at least 10 mM of an alkali metal hydroxide.

Abstract: The present invention relates to a cover (16) for a wiper blade (6), said cover (16) being configured to collaborate with a body (102) of the wiper blade (6) in a position of covering an opening formed in the body (102), the cover (16) comprising a plurality of guide tabs (56) and an upper wall (18), said upper wall (18) being dimensioned to cover part of the opening when the cover (16) is in the covering position, the guide tabs (56) extending the upper wall (18) perpendicularly and being configured to be able to hold the cover (16) in the covering position, characterized in that the cover (16) is configured to be able to be moved in the body (102) between a moved-clear position distant from the opening, and said position of covering of the opening, said cover comprising at least one retaining tab (36) extending the upper wall perpendicularly separately from the guide tabs (56), said retaining tab (36) comprising end-of-travel end-stop means (50) configured to halt the retaining tab (36) in said moved-clear

Abstract: A pneumatic tyre comprising an inner surface of the tyre, wherein a sound absorbing device component is connected to the inner surface of the tyre. The sound absorbing device component comprises a panel with a plurality of perforations and two sidewall sections, the sidewall sections being distinct from the panel, wherein the sidewall sections are connected to the inner surface of the tyre and arranged opposite of each other and wherein the panel is borne by the sidewall sections, thereby positioning the panel at a distance from the inner surface of the tyre and defining an inner volume enclosed by the panel, the sidewall sections and the inner surface. Furthermore, ?95 area-% of all perforations which permit access to the inner volume are located on the panel.

Abstract: A thermoelectric conversion device includes: a thermoelectric module layer, in which a thermoelectric conversion chip is surrounded by a thermal insulation rubber containing a rubber component and a hollow filler forming a plurality of air gaps that are independent from one another; an insulation base layer and an insulation intermediate layer, which are thermal-conductive insulation sheets and sandwiches the thermoelectric module layer; a heat diffusion layer, which has a higher thermal conductance than those of the insulation base layer and the insulation intermediate layer and is stacked on the insulation intermediate layer; and a thermal radiation layer, which has thermal conductivity and is stacked on the heat diffusion layer. And at least one pair among the adjacent layers is bonded through chemical bonds.

Abstract: A sealing valve plug structure includes a valve plug column corresponding to the drain opening formed in the side wall of an inner drum, and a counterweight hinged to the upper end of the valve plug column. The sealing valve installation structure is installed on the side wall of the drum, and the reset spring is clamped between the sealing valve installation structure and the valve plug column. The counterweight is used to generate an action, under the action of centrifugal force, to open the drain opening, and the valve plug column is reset by the reset spring to make the valve plug block the drain opening, to thereby open and close the drain opening. A cleaning-free washing machine having an inner drum sealed by the sealing valve plug structure is also disclosed.

Abstract: An inner drum comprises lifting ribs extending along a generatrix of the inner drum, each being hollow inside, a water-splashing surface of each of the lifting ribs has permeable holes to allow a hollow part of each of the lifting ribs to communicate with an inside of the inner drum, and a rear end of each is arranged close to an inner drum bottom, and provided with a water outlet structure. A no-clean washing machine is installed with the inner drum, the inner drum is a closed container with an opening closed by a door. When the inner drum rotates at a high speed, the washing water is guided towards the inner drum bottom and flows to a center of the bottom along a water guide flow channel on the bottom, and is discharged out of the inner drum through a water outlet connector of a central joint.

Abstract: An electronic device comprising a stylus; said stylus comprising a pointed end having a touch capable compression tip, and a top end, said top end comprising a rotatable element disposed of at the end of the top end, comprising a first electronic element mounted on said rotatable element, a second electronic element mounted below said rotatable element; a first contact point and a second contact point disposed on said stylus between said second electronic element and said pointed end; and at least one sensing button; said stylus comprising means for electronically communicating with said electronic device.

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

Abstract: The present invention relates to a method for the preparation of a flavouring, comprising the steps of (i) providing a reaction mixture comprising (a) yeast extract comprising at least 0.5 wt.% of glycosylamine and/or derivatives thereof and at least 1.0 wt.% of thiol containing compounds, wherein the weight percentage is by weight of dry matter of the yeast extract, (b) at least 1 wt.% of mineral acid or organic acid, by weight of the reaction mixture, and (c) from 0 to 20 wt.% of water by weight of the reaction mixture; and (iii) incubating the reaction mixture at a temperature in the range of 150 to 220° C., wherein shear is applied to the reaction mixture. The method preferably is natural. The invention also relates to a flavouring obtainable by the method. The flavouring is preferably a natural flavouring.

Abstract: An oil-in-water emulsified food composition with a pH of from 2 to 5, comprising water, vegetable oil in an amount of from 65 to 80 wt %, plant protein, bran of mustard seed or cereal grain, wherein the composition is free from egg-derived ingredients.

Abstract: A system which provides disaster notification contents includes: a DNC collecting module configured to communicate with a disaster notification contents (DNC) sending agency server and collect various DNCs; a DNC sending determination module configured to read the DNC collected by the DNC collecting module, check a DNC-related area, compare the DNC-related area with a preset user disaster interest area, and determine users whose disaster interest area matches the DNC-related area as DNC sending target users among the pre-stored users based on the result of comparison; and a DNC sending processing module configured to communicate with the DNC sending determination module, read the DNC sending target users list determined as DNC sending target users, and send the DNC collected by the DNC collecting module to the user information device owned by users included in the DNC sending target user list.

Abstract: An effective process of making N,N?-diacetyl-L-Cystine (“NDAC”), which process is fast, green, does not require labor-intensive isolation or purification of the product, by yielding products in desired ratio, and has improved yield and purity. The process comprising the steps of Forming a reaction mixture, starting with a cystine derivative di-tert- butyl-L-cystine as the dihydrochloride form; Acetylating said di-tert-butyl-L-cystine to obtain N,N?-diacetyl-di-tert- butyl-L-cystine; followed by Removing said tert- butyl groups from said N,N?-diacetyl-di-tert-butyl- L-cystine to obtain N,N?-diacetyl-L-cystine product; and Isolating said N,N?-diacetyl-L-Cystine product from said reaction mixture; wherein said acetylating agent is acetic anhydride.