Patents Assigned to Dade Behring Marburg GmbH
  • Publication number: 20050271678
    Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.
    Type: Application
    Filed: March 21, 2005
    Publication date: December 8, 2005
    Applicant: Dade Behring Marburg GmbH
    Inventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz Guertler
  • Patent number: 6960442
    Abstract: The present invention relates to immunoreactive peptides that are homologous with the region encompassing amino acid positions 450 to 655 of glycoprotein II of varicella zoster virus. In this context, preference is given to those peptides corresponding to segments of amino acids 505 to 647, 517 to 597, 535 to 584 or 545 to 582. The immunoreactive peptides are useful for methods of diagnosing varicella zoster virus infection.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: November 1, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Markus Eickmann, Dorothee Gicklhorn, Klaus Radsak, Hans-Peter Hauser, Bernhard Giesendorf
  • Patent number: 6949524
    Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: September 27, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Rajendra Singh, Harshvardhan Mehta
  • Patent number: 6932968
    Abstract: Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope-specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: August 23, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Mathias Fibi, Werner Stüber
  • Patent number: 6916667
    Abstract: Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: July 12, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Sharat Singh, Edwin F. Ullman
  • Patent number: 6905687
    Abstract: The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: June 14, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Harald Althaus, Hans-Peter Hauser
  • Patent number: 6887669
    Abstract: The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: May 3, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Mark A. Staples, Carolyn J. Haley, Richard F. Parrish, Wesley W. Zmolek
  • Patent number: 6869608
    Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: March 22, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
  • Patent number: 6866820
    Abstract: The invention relates to an appliance for opening and closing a reagent-container stopper in a partially or fully automatic analysis apparatus, and to the method, which is applied by means of this appliance, for opening and closing a reagent-container stopper in a partially or fully automatic analysis appliance.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 15, 2005
    Assignee: Dade Behring Marburg, GmbH
    Inventors: Ralf Otto, Hugo Wilmes, Hans-Dieter Sänger
  • Patent number: 6797481
    Abstract: Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner for each of the analytes, (iii) for each of the analytes, a first reagent comprising a member of a signal producing system, a ligand and an analyte analog, and (iv) a second reagent comprising a binding partner for the ligand. The binding of the binding partner for the ligand is affected by the presence of an analyte and alters the amount of signal produced by the member of the signal producing system. The signal thus is modulated if one or more of the analytes are present in the sample. The amount of the signal is determined and is related to the presence of one or more of the analytes in the sample. The method may be homogeneous or heterogeneous.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: September 28, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Edwin F. Ullman, Marcel Pirio, Mary C. Ericson, Daniel B. Wagner, Dariush Davalian
  • Patent number: 6791676
    Abstract: A method and apparatus for spectrophotometric and/or nephelometric analyses. The apparatus can be used in in-vitro diagnosis.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: September 14, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventor: Paul Meller
  • Patent number: 6783947
    Abstract: Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aqueous solutions, particularly in the presence of proteins at physiological pH. The present invention provides novel solutions to these problems, however, as novel compounds and compositions comprising protected haloketones are disclosed herein. Methods of preparing and using protected haloketones which are useful in a variety of applications—e.g., in assays and conjugation reactions—are also disclosed herein.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: August 31, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Steve de Keczer, Yen Ping Liu, Dariush Davalian, Nurith Kurn, Edwin F. Ullman
  • Patent number: 6773915
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: August 10, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht v. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6773923
    Abstract: The invention relates to a method for measuring the aggregation or agglutination of platelets, where a reaction mixture is mixed in a first reaction phase, and is mixed less vigorously or not at all in a second reaction phase following the first, and the measurement is preferably carried out in the second reaction phase.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 10, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventor: Jürgen Patzke
  • Publication number: 20040152074
    Abstract: The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16.
    Type: Application
    Filed: March 17, 2004
    Publication date: August 5, 2004
    Applicant: Dade Behring Marburg GmbH
    Inventors: Martin Muller, Lutz Gissmann
  • Patent number: 6750032
    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: June 15, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Carsten Schelp, Andreas Wiegand
  • Patent number: 6733989
    Abstract: Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof Expression of an SmaI fragment, which is about 1.0 kb in size, on the left-hand end of the HindIII R fragment makes it possible to synthesize, by genetic manipulation, a structural phosphoprotein of HCMV. This phosphoprotein, or immunogenic parts thereof, can be used as diagnostic aid or vaccine.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 11, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Mach, Heidi Meyer, Michael Bröker, Leander Lauffer
  • Publication number: 20040075838
    Abstract: The present invention relates to the field of the use of automated measurement systems in analysis and in in-vitro diagnosis. In particular, the apparatus described enables automatic quality control and validation of characteristic process engineering parameters, in particular characteristic optical parameters, during the measurement of scattered light signals.
    Type: Application
    Filed: November 19, 2003
    Publication date: April 22, 2004
    Applicant: Dade Behring Marburg GmbH
    Inventor: Paul Meller
  • Patent number: 6723317
    Abstract: The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: April 20, 2004
    Assignee: Dade Behring Marburg GmbH
    Inventors: Martin Müller, Lutz Gissmann
  • Patent number: RE38688
    Abstract: A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: January 18, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Heinz-Jürgen Friesen, Gerd Grenner, Hans-Erwin Pauly, Helmut Kohl, Klaus Habenstein, Joseph Stärk