Patents Assigned to Danmarks Tekniske Universitet
  • Patent number: 10930486
    Abstract: The invention relates to a device (10) for extracting volatile species from a liquid (20) connected to an inlet of an analysis instrument, such as a mass spectrometer (MS). The device has a chamber (4), a membrane (5) forming a barrier for the liquid at zero differential pressure between the inside and the outside of the chamber, and allowing passage of the volatile species at zero differential pressure between the inside and the outside of the chamber. The device has an inlet capillary channel (3) to feed in a carrier gas and prevent back-diffusion from the chamber, and an outlet capillary channel (6) which provides a significant pressure reduction, e.g. from atmospheric pressure in the chamber (4) to near-vacuum suitable for an MS. The invention combines the best of two worlds, i.e. the fast time-response of a DEMS system and the high sensitivity of a MIMS system, since a differential pumping stage is not needed.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: February 23, 2021
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Daniel Bøndergaard Trimarco, Peter Christian Kjærgaard Vesborg, Thomas Pedesen, Ole Hansen, Ib Chorkendorff
  • Patent number: 10912461
    Abstract: A method and apparatus for surface scanning in medical imaging is provided. The surface scanning apparatus comprises an image source, a first optical fiber bundle comprising first optical fibers having proximal ends and distal ends, and a first optical coupler for coupling an image from the image source into the proximal ends of the first optical fibers, wherein the first optical coupler comprises a plurality of lens elements including a first lens element and a second lens element, each of the plurality of lens elements comprising a primary surface facing a distal end of the first optical coupler, and a secondary surface facing a proximal end of the first optical coupler.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 9, 2021
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Oline Olesen, Rasmus Larsen, Jakob Wilm, Rasmus Ramsbøl Jensen
  • Patent number: 10900056
    Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: January 26, 2021
    Assignees: Danmarks Tekniske Universitet, Københavns Universitet
    Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
  • Patent number: 10889845
    Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: January 12, 2021
    Assignees: UNIVERSITY OF COPENHAGEN, DANMARKS TEKNISKE UNIVERSITET
    Inventors: Shamim Herbert Rahman, Carsten Behrens, Malene Bech Vester-Christensen, Henrik Clausen, Zhang Yang, Adnan Fevzi Halim, Eric Bennett
  • Patent number: 10883127
    Abstract: Described herein are variants of acetylserotonin O-methyltransferase (ASMT) as well as vectors and recombinant microbial host cells expressing such ASMT variant and their use in producing melatonin and related compounds. Preferred ASMT variants provide for a higher turnover of N-acetylserotonin into melatonin.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 5, 2021
    Assignee: Danmarks Tekniske Universitet
    Inventor: Hao Luo
  • Publication number: 20200402793
    Abstract: The invention relates to a method for creating an organic resist on a surface of a cooled substrate, the method comprising the steps of condensing a vapour into a solid film on the surface of the cooled substrate; patterning at least part of the solid film by exposing selected portions of said solid film to at least one electron beam thereby creating the organic resist on 5 the surface of the cooled substrate in accordance with a predetermined pattern; wherein the created organic resist remains essentially intact at ambient conditions; and using the created organic resist as a mask for creating semiconductor structures and/or semiconductor devices.
    Type: Application
    Filed: May 1, 2017
    Publication date: December 24, 2020
    Applicant: Danmarks Tekniske Universitet
    Inventors: Anpan HAN, William TIDDI, Marco BELEGGIA
  • Patent number: 10857678
    Abstract: A method and a system for manufacturing a mold for creation of complex objects by controlling and moving two end effectors of a robotic system is provided. The two end effectors have a flexible cutting element attached to, and extending between, the two end effectors. The method includes the steps of: defining at least one surface representing the inner surface of the mold; dividing the surface into a number of segments represented by planar curves on the surface; for each planar curve, calculating at least one elastic curve representing the planar curve; for each calculated elastic curve, calculating a set of data corresponding to placement and direction of the two end effectors for configuring the flexible cutting element to a shape corresponding to the calculated elastic curve; and sequentially positioning the end effectors according to each set of data. The flexible cutting element thereby cuts the mold from a block.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: December 8, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Jens Gravesen, David Brander, Jakob Andreas Bærentzen, Steen Markvorsen, Toke Bjerge Nørbjerg, Kasper Hornbak Steenstrup
  • Patent number: 10851365
    Abstract: Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: December 1, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Hao Luo, Jochen Förster
  • Patent number: 10856372
    Abstract: The present invention relates to a medical preparation container which includes a microwave power sensor assembly. The microwave powered sensor assembly includes a sensor configured to measure a physical property or chemical property of a medical preparation during its heating in a microwave oven. The microwave powered sensor assembly is configured for harvesting energy from a microwave radiation emitted by the microwave oven and energize the sensor by the harvested microwave energy.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: December 1, 2020
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Henrik Schneider, Kristian Lindberg-Poulsen
  • Patent number: 10767203
    Abstract: Described herein are variants of arylalkylamine N-acetyltransferase (AANAT) as well as vectors and recombinant microbial host cells expressing AANATs and variant AANATs and their use in producing N-acetylserotonin, melatonin and related compounds. Preferred AANAT variants provide for an increased yield of N-acetylserotonin.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: September 8, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventor: Hao Luo
  • Patent number: 10753795
    Abstract: The invention provides an infrared upconversion spectrometer for determining a mid-IR spectrum of received infrared light with a high resolution. The spectrometer applies upconversion to transform light in the mid-IR to the near-IR range where efficient detectors are available. The up-conversion causes divergence of the light, and in addition, the invention applies an extra dispersive element to record a spectrum.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: August 25, 2020
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Christian Pedersen, Peter Tidemand-Lichtenberg, Jeppe Seidelin Dam, Lasse Høgstedt
  • Patent number: 10748697
    Abstract: A resonant power converter for operation in the radio frequency range, preferably in the VHF, comprises at least one PCB-embedded transformer. The transformer is configured for radio frequency operation and comprises a printed circuit board defining a horizontal plane, the printed circuit board comprising at least two horizontal conductive layers separated by an isolating layer, a first embedded solenoid forming a primary winding of the transformer and a second embedded solenoid being arranged parallel to the first solenoid and forming a secondary winding of the transformer, wherein the first and second embedded solenoids are formed in the conductive layers of the printed circuit board, wherein each full turn of an embedded solenoid has a horizontal top portion formed in an upper conductive layer, a horizontal bottom portion formed in a lower conductive layer, and two vertical side portions formed by vias extending between the upper and the lower conducting layers.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: August 18, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Mickey P. Madsen, Jakob Døllner Mønster
  • Patent number: 10697892
    Abstract: Embodiments of the present invention include a cuvette (100) for use in determining a refractive index of a sample matter in a spectrophotometer (600), the cuvette comprising a container (102) for holding the sample matter, the container (102) having an entry window (121) that allows input radiation to reach the sample matter, the container furthermore having an exit window (122) that allows a part of the input radiation to exit the container part, the entry window and the exit window defining a radiation path; and comprising a photonic crystal (101) rigidly attached to the container or integrally formed in the container and arranged in the radiation path, the photonic crystal having a grating part (111) causing a reflectance spectrum of the photonic crystal to exhibit a resonance. A spectrophotometer is also provided.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: June 30, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Anders Kristensen, Kristian Tølbøl Sørensen, Emil Højlund-Nielsen
  • Publication number: 20200197541
    Abstract: The present invention describes an X-ray contrast composition for local administration, wherein the X-ray contrast composition exhibits contrast properties and wherein at least 60% of an administrated amount of said X-ray contrast composition remains more than 24 hours within 10 cm from an injection point when the X-ray contrast composition is administrated to a human or animal body.
    Type: Application
    Filed: January 2, 2020
    Publication date: June 25, 2020
    Applicants: DANMARKS TEKNISKE UNIVERSITET, NANOVI RADIOTHERAPY APS
    Inventors: Thomas Lars Andresen, Rasmus Irming Jolck, Morten Albrechtsen
  • Patent number: 10685052
    Abstract: This invention relates to a system for and a method (100) of searching a collection of digital information (150) comprising a number of digital documents (110), the method comprising receiving or obtaining (102) a search query, the query comprising a number of search terms, searching (103) an index (300) using the search terms thereby providing information (301) about which digital documents (110) of the collection of digital information (150) that contains a given search term and one or more search related metrics (302; 303; 304; 305; 306), ranking (105) at least a part of the search query search result according to one or more predetermined criteria providing a ranked search result, and providing at least a part of the ranked search result (106), wherein the ranking provides robust likelihood for low count terms by using the one or more search related metrics (302; 303; 304; 305; 306).
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: June 16, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventor: Ole Winther
  • Publication number: 20200113486
    Abstract: Disclosed is apparatus and method for motion tracking of a subject in medical brain imaging. The method comprises providing a light projector and a first camera; projecting a first pattern sequence (S1) onto a surface region of the subject with the light projector, wherein the subject is positioned in a scanner borehole of a medical scanner, the first pattern sequence comprising a first primary pattern (P1,1) and/or a first secondary pattern (P1,2); detecting the projected first pattern sequence (S1?) with the first camera; determining a second pattern sequence (S2) comprising a second primary pattern (P2,1) based on the detected first pattern sequence (S1?); projecting the second pattern sequence (S2) onto a surface region of the subject with the light projector; detecting the projected second pattern sequence (S2?) with the first camera; and determining motion tracking parameters based on the detected second pattern sequence (S2?).
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Applicant: Danmarks Tekniske Universitet
    Inventors: Oline Vinter OLESEN, Rasmus LARSEN, Rasmus R. PAULSEN, Liselotte HØJGAARD
  • Publication number: 20200102582
    Abstract: The present invention relates to the production of compounds comprised in pheromones, in particular moth pheromones, such as desaturated fatty alcohols and desaturated fatty acyl acetates and derivatives thereof, from a yeast cell.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 2, 2020
    Applicant: Danmarks Tekniske Universitet
    Inventors: Irina Borodina, Carina Holkenbrink, Marie Inger Dam, Christer Löfstedt, Baojian Ding, Hong-Lei Wang
  • Patent number: 10603289
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: March 31, 2020
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Patent number: 10598769
    Abstract: The invention relates to a coaxial direct-detection LIDAR system for measuring velocity, temperature and/or particulate density. The system comprises a laser source for emitting a laser light beam having a lasing center frequency along an emission path. The system further comprises an optical delivery system arranged in the emission path of the laser source, the optical delivery system being arranged for delivering the laser light beam in a measuring direction, the optical delivery system further being configured for collecting a return signal backscattered along the measuring direction. Finally, the system comprises a detector system arranged to receive the return signal from the optical delivery system, the detector system comprising a narrowband optical filter and a detector, the narrowband optical filter having a filter center frequency of a pass-band, wherein the center lasing frequency and/or the center filter frequency may be scanned.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: March 24, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Peter John Rodrigo, Christian Pedersen
  • Patent number: 10563271
    Abstract: The present invention provides a genetically modified lactic acid bacterium capable of producing diacetyl under aerobic conditions. Additionally the invention provides a method for producing diacetyl using the genetically modified lactic acid bacterium under aerobic conditions in the presence of a source of iron-containing porphyrin and a metal ion selected from Fe3+, Fe2+ and Cu2+. The lactic acid bacterium is genetically modified by deletion of those genes in its genome that encode polypeptides having lactate dehydrogenase (E.C 1.1.1.27/E.C.1.1.1.28); ?-acetolactate decarboxylase (E.C 4.1.1.5); water-forming NADH oxidase (E.C. 1.6.3.4); phosphotransacetylase (E.C.2.3.1.8) activity; and optionally devoid of or deleted for genes encoding polypeptides having diacetyl reductase ((R)-acetoin forming; EC:1.1.1.303); D-acetoin reductase; butanediol dehydrogenase ((R,R)-butane-2,3-diol forming; E.C. 1.1.1.4/1.1.1.-) and alcohol dehydrogenase (E.C. 1.2.1.10) activity.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: February 18, 2020
    Assignee: Danmarks Tekniske Universitet
    Inventors: Christian Solem, Peter Ruhdal Jensen, Jianming Liu