Abstract: The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite.

Abstract: The present invention relates to oleaginous yeast cells for the production of fatty alcohols and derivatives thereof, in particular desaturated fatty alcohols, desaturated fatty acyl acetates and desaturated fatty aldehydes. Also provided are methods for obtaining such compounds, which are useful in pheromone compositions.

Abstract: The present invention relates to an optical measuring system comprising a polymer-based single-mode fibre-optic sensor system (102), an optical interrogator (101), and an optical arrangement (103) interconnecting the optical interrogator (101) and the polymer-based single-mode fibre-optic sensor system (102). The invention further relates to an optical interrogator adapted to be connected to a polymer-based single-mode fibre-optic sensor system via an optical arrangement. The interrogator comprises a broadband light source arrangement (104) and a spectrum analysing arrangement which receives and analyses light reflected from the polymer-based single-mode fibre-optic sensor system.

Abstract: The present invention relates to a magnetometer (100) using optically detected magnetic resonance (ODMR), where a solid state material (10), such as diamond, with an ensemble of paramagnetic defects, such as nitrogen vacancies centers NV, is applied. An optical cavity (20) is optically excited by an irradiation laser (25) arranged therefore. A coupling structure (30) causes a microwave excitation (?) of the paramagnetic defects, and a permanent magnetic field (40, B_C) causes a Zeeman splitting of the energy levels in the paramagnetic defects. A probing volume (PV) in the solid state material is thereby defined by the spatially overlapping volume of the optical excitation by the irradiation laser (25), the coupling structure (30) also exciting the defects, and the constant magnetic field. The magnetometer then measures an unknown magnetic field by detecting emission (27), e.g.

Abstract: Described herein are variants of acetylserotonin O-methyltransferase (ASMT) as well as vectors and recombinant microbial host cells expressing such ASMT variant and their use in producing melatonin and related compounds. Preferred ASMT variants provide for a higher turnover of N-acetylserotonin into melatonin.

Abstract: The present disclosure relates to an asymmetric illumination lens and an illumination system implementing at least one such lens, for example for illuminating a stadium play field.

Abstract: Disclosed is a method for reducing the tar content in pyrolysis gas generated in a pyrolysis reactor (1). The method comprises the steps of: guiding the pyrolysis gas through a filter (2) to remove at least 90% of all the particles in the pyrolysis gas having a particle size down to 7? and preferably down to 4? from the pyrolysis gas, partially oxidizing the pyrolysis gas in a partial oxidation reactor (3) to remove tar from the pyrolysis gas, and guiding the pyrolysis gas through a coke bed (4) to further remove tar from the pyrolysis gas. Furthermore, a two-stage gasifier (6) is disclosed.

Abstract: The present invention provides a method of treating wastewater in a wastewater system. The wastewater system comprises a treatment plant comprising a treatment space and a sewer system comprising a sewer space. The treatment plant further comprises a treatment inlet for supplying wastewater to the treatment system from the sewer system. The method comprises the step of: providing a treatment parameter being significant for purification of wastewater in the treatment plant, determining an actual spare plant capacity indicating an amount of wastewater which can be supplied to the treatment space, and determining an actual spare wastewater storage volume indicating an amount of wastewater which can be retained in the sewer space. The amount of wastewater supplied through the treatment inlet to the treatment plant is varied based on the treatment parameter, the actual spare plant capacity, and the actual spare wastewater storage volume.

Abstract: The present invention relates to an elastomeric composition comprising a silicone rubber, glycerol, at least one crosslinking agent, and optionally one or more excipients, wherein said glycerol is present as discrete droplets in the silicone rubber, obtainable through the application of high shear forces.

Abstract: Disclosed is a slurry drying plant (1) comprising a slurry inlet (2) for feeding slurry to the slurry drying plant (1) and two or more meshing screw conveyors (3, 4) arranged to at least partly divide the slurry while conveying the slurry in a transport direction from the slurry inlet (2) to a slurry outlet (5). The slurry drying plant (1) further includes slurry heating means (6) comprising means for passing superheated steam substantially at atmospheric pressure past the slurry and the two or more meshing screw conveyors (3, 4), while they are conveying the slurry. Furthermore, a method for drying slurry and use of a slurry drying plant (1) is disclosed.

Abstract: A squeezed light generator (SLG) for generating squeezed light (SQL) is disclosed, said squeezed light generator (SLG) comprising: —a waveguide (WG) being arranged to receive fundamental wavelength laser light (FWL), the waveguide (WG) comprising a second harmonic generator (SHG) for generating second harmonic light (SHL) from the fundamental wavelength light (FWL), —an optical cavity (OC) resonant for both fundamental wavelength light (FWL) and the second harmonic light (SHL), the optical cavity (OC) being arranged to receive the second harmonic light (SHL), and —a parametric down converter (PDC) arranged inside said optical cavity (OC), the parametric down converter (PDC) being adapted for generating said squeezed light (SQL) using said second harmonic light (SHL). Also, a method for generating squeezed light (SQL) is disclosed.

Abstract: An electrochemical device for diagnostic purposes, and particularly point-of-care diagnostic purposes, is capable of detecting quorum sensing molecules, such as AHL, within a biological sample with high precision. The device includes at least one reference electrode (RE), at least one counter electrode (CE), and two or more working electrodes (WEs). Each working electrode differs from the other working electrode(s) with respect to at least one of the following characteristics: surface area, size, material, and coating. The device also has a sample receiving area for receiving a biological sample, wherein the electrodes and the sample receiving area is fluidly connected, and a means for transferring the sample to the electrodes for measurement, and a means for displaying a result of the measurement.

Abstract: There is presented a method for geometrically modifying plasmonic structures on a support structure, such as for printing or recording, said method comprising changing a geometry specifically of plasmonic structures, wherein said changing the geometry is carried out by photothermally melting at least a portion of each of the plasmonic structures within the second plurality of plasmonic structures by irradiating, the plasmonic structures with incident electromagnetic radiation having an incident intensity in a plane of the second plurality of plasmonic structures, wherein said incident intensity is less than an incident intensity required to melt a film of a corresponding material and a corresponding thickness as the plasmonic structures within the second plurality of plasmonic structures.

Abstract: The present invention relates to a case hardened component of a titanium alloy, the component having a diffusion zone of a thickness of at least 50 ?l?l, as calculated from the surface of the component, the diffusion zone comprising oxygen and carbon in solid solution and having a distinct phase of a carbo-oxide compound having the composition TiOxC1-x, wherein x is a number in the range of 0.01 to 0.99, which diffusion zone has a microhardness of at least 800 HV0.025 and which carbo-oxide compound has a microhardness of at least 1200 HV0.025. In another aspect the invention relates to a method of producing the case hardened component. In a further aspect the invention relates to a method of oxidising a component of a Group IV metal.

Abstract: A method and apparatus for surface scanning in medical imaging is provided. The surface scanning apparatus comprises an image source, a first optical fiber bundle comprising first optical fibers having proximal ends and distal ends, and a first optical coupler for coupling an image from the image source into the proximal ends of the first optical fibers, wherein the first optical coupler comprises a plurality of lens elements including a first lens element and a second lens element, each of the plurality of lens elements comprising a primary surface facing a distal end of the first optical coupler, and a secondary surface facing a proximal end of the first optical coupler.

Abstract: The present invention relates to a microwave powered sensor assembly for microwave ovens. The microwave powered sensor assembly includes a microwave antenna to generate an RF antenna signal in response to microwave radiation at a predetermined excitation frequency. A direct current (dc) power supply circuit of the microwave powered sensor assembly is operatively coupled to the RF antenna signal to extract energy from the RF antenna signal and produce a power supply voltage. A sensor is connected to the power supply voltage and configured to measure a physical or chemical property of a food item under heating in a microwave oven chamber.

Abstract: The present invention relates to mammalian cells modified to provide for improved expression of a recombinant protein of interest. In particular, the invention relates to CHO cells and other host cells in which the expression of one or more endogenous secreted proteins has been disrupted, as well as to the preparation, identification and use of such cells in the production of recombinant proteins.

Abstract: A reinforcement system for anchoring tendons for structural reinforcing a structure such as a concrete structure, said reinforcement system comprises at least one anchor and at least one tendon, said anchor is adapted to fix said tendon in and/or outside said structure, wherein said reinforcement system comprises a ductility element, which is positioned in structural connection between said tendon and said anchor, said ductility element comprising weakened deformation zones being deformable so that the length of the ductility is increased or decreased in an axial direction along the length of said tendon.

Abstract: The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

Abstract: An apparatus for carrying out Raman spectroscopy on a sample includes a light source for providing a beam of excitation radiation, and an optical system including a spectrograph. The spectrograph includes a grating that divides a beam of scattered light into a spectrum of spatially separated wavelength components and to direct a portion of the spectrum to a detector. The spectrograph includes: 1) a first lens system for focusing the portion of the spectrum onto the detector and 2) a second lens system-configured to provide a focal plane with focal point in the optical path for focusing the beam of excitation radiation and/or the beam of scattered radiation at the focal point. The apparatus including a reference sample arranged in the focal plane, in particular at the focal point, for obtaining a reference spectrum from the reference sample.