Abstract: Association of Type II diabetes and a locus on chromosome 5 is disclosed. In particular, the gene KChIP1 within this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those who have Type II diabetes or are at risk of developing Type II diabetes, in particular those that are non-obese are described.

Abstract: The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-1?, TNF? or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.

Abstract: A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

Abstract: Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described.

Abstract: Linkage of Myocardial Infarction (MI) to a locus on chromosome 13q12-13 is disclosed. In particular, the FLAP gene within this locus is shown by association analysis to be a susceptibility gene for MI and stroke. Pathway targeting for drug delivery and diagnosis applications in identifying those at risk of developing MI or stroke, in particular are described.

Abstract: The present invention relates to a method for desalting nucleic acid samples. The method involves contacting a liquid sample comprising a nucleic acid and an ionic salt with an ion exchanger comprising an insoluble phosphate salt, removing said liquid, and eluting said nucleic acid from the ion exchanger. The desalted nucleic acids provided by the methods of the invention are suitable for a wide variety of analytic and diagnostic applications, including high-throughput assays.

Abstract: The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1?, TNF? or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.

Abstract: The present invention relates to the usage pattern, commonly found in many software applications, of defining sets of objects based on object attributes. A specifically designed set definition language for defining sets, called SDL, is described and a software system that implements this language efficiently on top of a standard relational database management system (RDBMS) is presented. The unique features of the SDL language are the implicit constraints that are enforced on the relational data that belong to the objects. Unique to the SDL system is also the logical metadata of dimensions that enables the SDL system to enforce these constraints across relations. The SDL system utilizes several optimization techniques to enable efficient implementation on top of RDBMS. It is also shown how the SDL language and the SQL language can be merged with bidirectional inlining using syntactic gates. Query composition tools are also described that facilitate the creation of SDL expressions.

Abstract: The present invention relates to the usage pattern, commonly found in many software applications, of defining sets of objects based on object attributes. A specifically designed set definition language for defining sets, called SDL, is described and a software system that implements this language efficiently on top of a standard relational database management system (RDBMS) is presented. The unique features of the SDL language are the implicit constraints that are enforced on the relational data that belong to the objects. Unique to the SDL system is also the logical metadata of dimensions that enables the SDL system to enforce these constraints across relations. The SDL system utilizes several optimization techniques to enable efficient implementation on top of RDBMS. It is also shown how the SDL language and the SQL language can be merged with bidirectional inlining using syntactic gates. Query composition tools are also described that facilitate the creation of SDL expressions.

Abstract: A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

Abstract: A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

Abstract: A role of the human PAOD1 gene in peripheral arterial occlusive disease is disclosed. Methods for diagnosis, prediction of clinical course and treatment for peripheral arterial occlusive disease using polymorphisms in the PAOD1 gene are also disclosed.

Abstract: A role of the human MATN3 gene in osteoarthritis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoarthritis using polymorphisms in the MATN3 gene are also disclosed.

Abstract: A role of the human BMP2 gene in osteoporosis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoporosis using polymorphisms in the BMP2 gene are also disclosed.

Abstract: The present invention relates to a method for desalting nucleic acid samples. The method involves contacting a liquid sample comprising a nucleic acid and an ionic salt with an ion exchanger comprising an insoluble phosphate salt, removing said liquid, and eluting said nucleic acid from the ion exchanger. The desalted nucleic acids provided by the methods of the invention are suitable for a wide variety of analytic and diagnostic applications, including high-throughput assays.

Abstract: A role of the human BMP2 nucleic acid in osteoporosis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoporosis or a susceptibility to osteoporosis using polymorphisms in the BMP2 nucleic acid, alone or in combination with other assays, are also disclosed.

Abstract: The gene for hypocretin (orexin) receptor 2 (HCRTR2), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR2 gene, as well as methods of therapy of narcolepsy.

Abstract: The present invention relates to the usage pattern, commonly found in many software applications, of defining sets of objects based on object attributes. A specifically designed set-definition language for defining sets, called SDL, is described and a software system that implements this language efficiently on top of a standard relational database management system (RDMS) is presented. The unique features of the SDL language are the implicit constraints that are enforced on the relational data that belong to the objects. Unique to the SDL system is also the logical metadata of dimensions that enables the SDL system to enforce these constraints across relations. The SDL system utilizes several optimization techniques to enable efficient implementation on top of RDMS. Query composition tools are also described and facilitate the creation of SDL expressions.

Abstract: A role of the human PAOD1 gene in peripheral arterial occlusive disease is disclosed. Methods for diagnosis, prediction of clinical course and treatment for peripheral arterial occlusive disease using polymorphisms in the PAOD1 gene are also disclosed.

Abstract: The invention discloses a system and methods that facilitate efficient querying of tables referencing spatial object types. The methods enable meaningful indexing of the tables as well as rewriting of queries with respect to the spatial structures. Dynamic schema extraction using efficient proper coloring algorithms for large sets of spatial objects is disclosed that structures the data in such a way that complex spatial queries and grouping of objects is replaced with traditional relational joins. This enables a relational database system to harness its entire query optimizing capability when querying tables referencing spatial objects.