Abstract: A role of the human BMP2 gene in osteoporosis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoporosis using polymorphisms in the BMP2 gene are also disclosed.

Abstract: A method/operator is disclosed that adjusts measurements during processing in a multidimensional data cube. The online “depth-of-field” operator disclosed varies the density of points in a representation of the multidimensional cube. The operator may be applied to any collection of dimensions and relations supported by the dimensions, using hierarchical structures to control the adjustments. It allows one to experiment online with the definition of relations during multidimensional possessing, thereby controlling the output of the synthesizing process. The operator may be used to equate attributes based on their hierarchical positions when processing measurements in a hypercube. Furthermore, it may be used to reveal hidden dependencies between variables when working with measurements with varying levels of granularity.

Abstract: The gene for hypocretin (orexin) receptor 1 (HCRTR1), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR1 gene, as well as methods of therapy of narcolepsy.

Abstract: This invention provides an automated system for the processing of data packets, composed of personal identifiers and personal data, such that the personally identifiable data sent by one party may be considered anonymous once received by a second party. The invention uses secret sharing techniques to facilitate distributed key management of the mapping functions and strong authentication to allow the system to be operated remotely.

Abstract: Methods are described for detecting a deletion in the C4A gene (e.g., for detecting C4AQ0), by performing long range polymerase chain reaction amplification on a test sample comprising genomic DNA. The methods amplify target DNA comprising a retroviral insert in intron 9 of the C4A gene using primers designed such that PCR products are formed only if the test sample comprises genomic DNA comprising a deletion in the C4A gene; alternatively, the methods amplify target DNA comprising the junction between intron 9 and the retroviral insert in intron 9 of the C4A gene using primers designed such that PCR products are formed only if the test sample comprises genomic DNA that does not comprise the deletion in the C4A gene. Alternatively, primers are designed such that PCR products have detectably different sizes, depending on whether or the test sample comprises genomic DNA that comprises the deletion in the C4A gene.