Abstract: A graphical user interface (GUI) presents to a clinician/user coded medical information in at least one logical hierarchy, and accepts selections of the presented information made by the user. An electronic medical record generator records user selections into an electronic medical record. The logical hierarchy may be organized, for example, by physiological system, or by type of examination. The GUI includes an image of a body, from which a user can select a body part for examination, examination method selection controls, and one or more sets of buttons optimized for a touchscreen. Each button has a bulbous portion and a narrower label portion. The bulbous portion is large enough to be easily contacted with the user's finger without the user's finger contacting an adjacent button. The narrow label portion protrudes from the bulbous portion and can contain a text label. The controls can thus be lined up alternately in opposite orientations so that they are tightly stacked.

Abstract: A system for editing the dimension structure associated with a data cube is revealed. The editing may be used to enforce given criteria on the cube. This includes modifying the cube in order to satisfy regulations requiring researchers to protect information about individuals, such as medical, genealogy and genetics records. The inference control methods disclosed therefore enable safe aggregated datasets to be released to researchers. When combined with information theoretic methods, the invention method of editing the dimension structures may be used to express clearly and discover correlations that exist in the dataset. This mining of the data and editing of the dimension structure allows the user of a simple multidimensional cube viewer to visually verify the patterns discovered.

Abstract: Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

Abstract: The invention discloses methods and apparatus that facilitate efficient querying of tables referencing semistructured data such as digraphs and other domains with complex grouping structure. The invention methods enable meaningful indexing of the tables as well as rewriting of queries with respect to the structures. Dynamic schema extraction using proper coloring algorithms is disclosed that structures the semistructured data in such a way that complex set operations and grouping are replaced with traditional relational joins. This enables a relational database system to harness its entire query optimizing capability when querying tables referencing semistructured data.

Abstract: Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

Abstract: A graphical SQL query generator and query operators are disclosed. The query tool embeds matrix objects that are used for building and transforming SQL based queries, views, data cubes and other relations including “virtual” or calculated relations. The matrix objects trace the structure of a relation to its source data and thereby make the structure of complex multilayered database queries transparent to the end-user. The methods are especially useful in data warehousing where the buildup of fact tables in star or other schemas needs to be transparent to the user. Thus, a system is disclosed that is able to quickly reveal how data warehousing schemas and relations in SQL and similar relational type databases evolve from source data and each other into more complicated structures. It supports the creation and maintenance of complex database structures such as scientific studies and other decision support structures as well as simplifying ad-hoc querying of SQL databases.

Abstract: Methods for purifying nucleic acids from biological fluids are disclosed as well as an apparatus for preforming the methods. The methods and apparatus circumvent traditional centrifugation steps using a plurality of vacuum steps to separate and isolate nucleic acids. The vacuum processing and apparatus allow the direct collection of bound nucleic acids from to collection vessels avoiding further manipulation.

Abstract: A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

Abstract: The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1&bgr;, TNF&agr; or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.

Abstract: Methods of identifying DNA fragments comprising DNA that is identical by descent for two individuals are disclosed.

Abstract: The current invention discloses methods for transforming a set of relations into multidimensional data cubes. A syntheses process is disclosed that dynamically and with minimal user input eliminates ambiguities when populating a data cube by introducing table-like virtual relations. The methods are generic and applicable to many data warehouse designs. The methods support relational OLAP for a wider variety of data and structures than possible using current relational implementation schemas.

Abstract: A user-interactive computer program provides drug advice. Drugs are grouped according to their clinical and chemical characteristics in a supporting data base. For each drug, a drug database contains detailed information on pharmacokinetics, pharmaco-dynamics and drug-specific details. In response to user interaction with areas displayed on the screen, the computer program obtains pertinent drug interaction information from the database. With the obtained information, the computer program supports display of graphical screen views. Contents of the screen views include symbols for indicating respective drugs, geometrically distinguishing lines for indicating interaction between drugs, and text descriptions of drug information. Further included in the screen views are respective symbols for indicating drug warnings for pregnant or lactating women and sportspersons. Color coding may also be employed in the screen views to indicate degree of effect or warning.

Abstract: The plate mover, according to the present invention, is an integrated stage mover and stereo microscope which moves crystallization plates through the microscope field of view. A digital camera attached to the microscope can capture images of crystallization results as the crystallization plate is moved through the field of vision of the microscope. The plate mover is suitably controlled by a computer having a CPU and a memory, wherein a software application, such as Crystal Monitor™ resides in the computer. Crystal Monitor™ is a suitable software application for crystallization results data entry which can use voice recognition commands to enter a crystallization result in a database. Real-time images can be viewed on a computer monitor during operation of the plate mover. Suitably, an automatic observation feature causes the crystallization results in a plate with minimal user intervention.

Abstract: Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia.

Abstract: The gene for hypocretin (orexin) receptor 1 (HCRTR1), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR1 gene, as well as methods of therapy of narcolepsy.

Abstract: The current mechanism discloses methods for transforming a set of heterogeneous relations into multidimensional data cubes. A syntheses process is disclosed that dynamically and with minimal user input eliminates ambiguities in a populated hypercube. Including, ambiguities reflecting dependencies between dimensions in the hypercube as well as reflecting the need for supporting points in the cube with realistic observations. The hypercubes also support complex dimension structures, complex operations and hierarchies that are not necessary regular or of aggregation type. The methods are generic and applicable to any data warehouse design. The methods enable relational OLAP for a wider variety of data and structures than possible using current relational implementation schemas.

Abstract: Nucleic acids comprising the neuregulin-1-associated gene 1 (NRG1AG1) and encoding NRG1AG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1AG1 polypeptides; NRG1AG1 polypeptides; antibodies that bind to NRG1AG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1AG1 polypeptide or which identify NRG1AG1 binding agents, and the agents or binding agents identified by the assays; NRG1AG1 therapeutic agents, including the NRG1AG1 nucleic acids, NRG1AG1 polypeptides, or agents that alter the activity of an NRG1AG1 polypeptides; pharmaceutical compositions comprising the NRG1AG1 therapeutic agents; as well as methods of therapy of schizophrenia.

Abstract: A graphical SQL query generator and query operators are disclosed. The query tool embeds matrix objects that are used for building and transforming SQL based queries, views, data cubes and other relations including “virtual” or calculated relations. The matrix objects trace the structure of a relation to its source data and thereby make the structure of complex multilayered database queries transparent to the end-user. The methods are especially useful in data warehousing where the buildup of fact tables in star or other schemas needs to be transparent to the user. Thus, a system is disclosed that is able to quickly reveal how data warehousing schemas and relations in SQL and similar relational type databases evolve from source data and each other into more complicated structures. It supports the creation and maintenance of complex database structures such as scientific studies and other decision support structures as well as simplifying ad-hoc querying of SQL databases.

Abstract: A method/operator is disclosed that modifies dimension structures and relations during processing in a multidimensional data cube. The online “blowup” operator disclosed uses one or more hierarchical structures to expand a hypercube in order to reveal internal connections between attributes in relations associated with the hypercube. The operator is generic and may be applied to any dimension using hierarchical structures to guide the process. Furthermore, it is applicable to any data warehouse design. The methods enable a user, performing multidimensional analysis, to view, online, internal connections between attributes when going from one level to another in the hierarchical structures. Such as when comparing complex health related statistics for individuals across different age periods or for individuals versus their ancestors. The methods disclosed, facilitate OLAP for more complex data than current designs do.

Abstract: The gene for hypocretin (orexin) receptor 2 (HCRTR2), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR2 gene, as well as methods of therapy of narcolepsy.