Patents Assigned to Demerx, Inc.
  • STABLE CRYSTALLINE NORIBOGAINE SALT ANSOLVATES
    Publication number: 20170022194
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: DemeRx, Inc.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • NORIBOGAINE SALT TABLETS
    Publication number: 20170022193
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: DemeRx, Inc.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • Methods and compositions for treating migraines using noribogaine
    Patent number: 9549935
    Abstract: This invention provides methods and compositions for treating or preventing migraine headache and/or symptoms thereof in a subject. The method comprises administering to the subject in need thereof a therapeutically effective amount of noribogaine, noribogaine derivative, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: January 24, 2017
    Assignee: DEMERX, INC.
    Inventor: Holger Weis
  • Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
    Patent number: 9550789
    Abstract: Provided herein are halogenated indole and benzofuran derivatives of isoquinuclidene and intermediates thereto, and processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (?) and (+) noribogaine, in substantially enantiomerically pure forms.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: January 24, 2017
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Mark Kinch
  • SYNTHETIC VOACANGINE
    Publication number: 20160311823
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Applicant: DemeRx, Inc.
    Inventor: Robert M. Moriarty
  • Synthetic voacangine
    Patent number: 9469649
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: October 18, 2016
    Assignee: DEMERX, INC.
    Inventor: Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 9403817
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 2, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, Jr.
  • Stereoselective total synthesis of noribogaine
    Patent number: 9403837
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: August 2, 2016
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Methods and compositions for preparing and purifying noribogaine
    Patent number: 9394294
    Abstract: Disclosed are methods and compositions for purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: July 19, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr.
  • Noribogaine compositions
    Patent number: 9358237
    Abstract: Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: June 7, 2016
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Methods for acute and long-term treatment of drug addiction
    Patent number: 9345711
    Abstract: This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL (AUC/24 h) under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: May 24, 2016
    Assignee: DEMERX, INC.
    Inventor: Lawrence Friedhoff
  • PHOSPHATE ESTERS OF NORIBOGAINE
    Publication number: 20160115185
    Abstract: Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 28, 2016
    Applicant: DEMERX, INC.
    Inventors: Richard D. Gless, JR., Robert M. Moriarty
  • NORIBOGAINE SALT ANSOLVATES
    Publication number: 20160108043
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Application
    Filed: May 23, 2015
    Publication date: April 21, 2016
    Applicant: DEMERX, INC.
    Inventors: Richard D. Gless, JR., William C. Schinzer
  • Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
    Patent number: 9308272
    Abstract: This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 12, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless
  • METHODS AND COMPOSITIONS FOR TREATING MIGRAINES USING NORIBOGAINE
    Publication number: 20160008372
    Abstract: This invention provides methods and compositions for treating or preventing migraine headache and/or symptoms thereof in a subject. The method comprises administering to the subject in need thereof a therapeutically effective amount of noribogaine, noribogaine derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 17, 2015
    Publication date: January 14, 2016
    Applicant: DemeRx, Inc.
    Inventor: Holger Weis
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20150361080
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: May 21, 2015
    Publication date: December 17, 2015
    Applicant: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, JR., Robert M. Moriarty
  • METHODS AND COMPOSITIONS FOR SUSTAINED NORIBOGAINE TREATMENT
    Publication number: 20150342959
    Abstract: This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine at a dosage that provides an average serum concentration of 50 ng/mL to 180 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: February 17, 2015
    Publication date: December 3, 2015
    Applicant: DemeRx, Inc.
    Inventor: Lawrence Friedhoff
  • Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
    Patent number: 9150584
    Abstract: Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (?) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: October 6, 2015
    Assignee: DEMERX, INC.
    Inventor: Robert M. Moriarty
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF SUBSTANCE ABUSE USING IBOGAINE
    Publication number: 20150258114
    Abstract: This invention is directed to a method of treating substance addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with ibogaine, ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 17, 2015
    Applicant: DemeRX, Inc.
    Inventor: Lawrence Friedhoff
  • METHODS AND COMPOSITIONS FOR PRE-SCREENING PATIENTS FOR TREATMENT WITH NORIBOGAINE
    Publication number: 20150257667
    Abstract: This invention is directed to a method for pre-screening an opioid-addicted patient to determine the patient's tolerance for a therapeutic dose of noribogaine.
    Type: Application
    Filed: February 17, 2015
    Publication date: September 17, 2015
    Applicant: DemeRX, Inc.
    Inventor: Lawrence Friedhoff