Patents Assigned to Demerx, Inc.
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF ALCOHOL DEPENDENCE
    Publication number: 20150258105
    Abstract: This invention is directed to a method of treating alcohol dependence, including acute and post-acute withdrawal symptoms, comprising treating an alcohol dependent patient with noribogaine, noribogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: February 17, 2015
    Publication date: September 17, 2015
    Applicant: DEMERX, INC.
    Inventors: Emeline Maillet, Lawrence Friedhoff
  • LOW DOSE ADMINISTRATION OF IBOGAINE FOR TREATING NICOTINE ADDICTION AND PREVENTING RELAPSE OF NICOTINE USE
    Publication number: 20150258109
    Abstract: This invention relates generally to methods and compositions for the treatment of nicotine addiction by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses. This invention further relates generally to methods and compositions for the treatment or prevention of relapse of nicotine use by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 17, 2015
    Applicant: DEMERX, INC.
    Inventors: Emeline Maillet, Lawrence Friedhoff
  • METHODS AND COMPOSITIONS FOR TREATING DEPRESSION USING IBOGAINE
    Publication number: 20150258112
    Abstract: This invention provides a method for treating depression and/or post-traumatic stress disorder in a patient, comprising administering to the patient in need thereof a therapeutically effective amount of ibogaine, ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 17, 2015
    Applicant: DemeRX, Inc.
    Inventor: Lawrence Friedhoff
  • USE OF NORIBOGAINE FOR THE TREATMENT OF PAIN
    Publication number: 20150258104
    Abstract: This invention is directed to methods of treating pain in patients comprising treating patients with noribogaine at a dosage that provides an average serum concentration of 50 ng/mL to 180 ng/mL, including under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: February 17, 2015
    Publication date: September 17, 2015
    Applicant: DemeRX, Inc.
    Inventor: Lawrence Friedhoff
  • USE OF IBOGAINE FOR THE TREATMENT OF PAIN
    Publication number: 20150258113
    Abstract: This invention is directed to methods of treating pain in patients comprising treating patients with ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof at a therapeutic dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 17, 2015
    Applicant: DemeRX, Inc.
    Inventor: Lawrence Friedhoff
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF ALCOHOL DEPENDENCE USING IBOGAINE
    Publication number: 20150258110
    Abstract: This invention is directed to a method of treating alcohol dependence, including acute and post-acute withdrawal symptoms, comprising treating an alcohol dependent patient with ibogaine, ibogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 17, 2015
    Applicant: DEMERX, INC.
    Inventors: Emeline Maillet, Lawrence Friedhoff
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF SUBSTANCE ABUSE
    Publication number: 20150258106
    Abstract: This invention is directed to a method of treating drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine or a pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides a therapeutic serum concentration. In one embodiment, the average serum concentration is 50 ng/mL to 180 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds, and preferably about 30 milliseconds.
    Type: Application
    Filed: February 17, 2015
    Publication date: September 17, 2015
    Applicant: DEMERX, INC.
    Inventor: Lawrence Friedhoff
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF OPIOID AND OPIOID-LIKE DRUG ADDICTION
    Publication number: 20150246055
    Abstract: This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with ibogaine, ibogaine derivative, or pharmaceutically acceptable salt or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 3, 2015
    Applicant: DEMERX, INC.
    Inventor: Lawrence Friedhoff
  • LOW DOSE NORIBOGAINE FOR TREATING NICOTINE ADDICTION AND PREVENTING RELAPSE OF NICOTINE USE
    Publication number: 20150238503
    Abstract: This invention provides methods and compositions for treating nicotine addiction or treating or preventing nicotine cravings in a subject. The method comprises administering to the patient in need thereof a therapeutically effective amount of noribogaine, noribogaine derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 17, 2015
    Publication date: August 27, 2015
    Applicant: DemeRX, Inc.
    Inventors: Emeline Maillet, Lawrence Friedhoff
  • METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION
    Publication number: 20150231147
    Abstract: This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine at a dosage that provides an average serum concentration of about 50 ng/mL to about 180 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 20, 2015
    Applicant: DemeRx, Inc.
    Inventor: Lawrence Friedhoff
  • Phosphate esters of noribogaine
    Patent number: 9051343
    Abstract: Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 9, 2015
    Assignee: DEMERX, INC.
    Inventors: Richard D. Gless, Jr., Robert M. Moriarty
  • Substituted noribogaine
    Patent number: 9045481
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: June 2, 2015
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty
  • Noribogaine salt ansolvates
    Patent number: 9040520
    Abstract: Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 26, 2015
    Assignee: DemeRx, Inc.
    Inventors: Richard D. Gless, Jr., William C. Schinzer
  • METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE
    Publication number: 20150133655
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: October 14, 2014
    Publication date: May 14, 2015
    Applicant: DEMERX, INC.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, JR.
  • SYNTHETIC VOACANGINE
    Publication number: 20150094466
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 2, 2015
    Applicant: DemeRx, Inc.
    Inventor: Robert M. Moriarty
  • Substituted noribogaine
    Patent number: 8940728
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: January 27, 2015
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty
  • Stereoselective total synthesis of noribogaine
    Patent number: 8937061
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: January 20, 2015
    Assignee: DemeRx, Inc.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • STEREOSELECTIVE TOTAL SYNTHESIS OF NORIBOGAINE
    Publication number: 20150005492
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Applicant: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Synthetic voacangine
    Patent number: 8877921
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: November 4, 2014
    Assignee: DemeRx, Inc.
    Inventor: Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 8859764
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: October 14, 2014
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, Jr.