Patents Assigned to Demerx, Inc.
  • Sulfate esters of noribogaine
    Patent number: 8853201
    Abstract: Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: October 7, 2014
    Assignee: DemeRx, Inc.
    Inventors: Richard D. Gless, Jr., Robert M. Moriarty
  • METHODS FOR NON-TOXIC TREATMENT FOR DRUG WITHDRAWAL
    Publication number: 20140288056
    Abstract: The disclosure provides a method to administer noribogaine to a human patient having drug addiction in dosages that provide efficacy without leading to any significant deleterious clinical signs.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: DEMERX, INC.
    Inventor: Lawrence Friedhoff
  • Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
    Patent number: 8802832
    Abstract: This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: August 12, 2014
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr.
  • Methods and compositions for preparing and purifying noribogaine
    Patent number: 8765737
    Abstract: Disclosed are methods and compositions for purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: July 1, 2014
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr.
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20140179684
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: January 2, 2013
    Publication date: June 26, 2014
    Applicant: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, JR., Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 8742096
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: June 3, 2014
    Assignee: DemeRx, Inc.
    Inventors: Robert M. Moriarty, Simon Mbua Ngale Efange
  • N-substituted noribogaine prodrugs
    Patent number: 8741891
    Abstract: This invention relates generally to prodrugs of noribogaine. This invention also relates to pharmaceutical compositions comprising the prodrugs of noribogaine as well as method of treating pain, addiction and/or stress using such compounds and/or pharmaceutical compositions.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: June 3, 2014
    Assignee: DemeRx, Inc.
    Inventor: Deborah C. Mash
  • Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
    Patent number: 8637648
    Abstract: This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: January 28, 2014
    Assignee: Demerx, Inc.
    Inventors: Deborah C. Mash, Robert M. Moriarty
  • SYNTHETIC VOACANGINE
    Publication number: 20130211073
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Application
    Filed: January 24, 2013
    Publication date: August 15, 2013
    Applicant: DemeRx, Inc.
    Inventor: DemeRx, Inc.
  • INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM
    Publication number: 20130211074
    Abstract: Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (?) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.
    Type: Application
    Filed: January 24, 2013
    Publication date: August 15, 2013
    Applicant: DemeRx, Inc.
    Inventor: DemeRx, Inc.
  • STEREOSELECTIVE TOTAL SYNTHESIS OF NORIBOGAINE
    Publication number: 20130165647
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 27, 2013
    Applicant: DEMERX, INC.
    Inventor: DemeRx, Inc.
  • PHOSPHATE ESTERS OF NORIBOGAINE
    Publication number: 20130165414
    Abstract: Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 27, 2013
    Applicant: DEMERX, INC.
    Inventor: DemeRx, Inc.
  • SULFATE ESTERS OF NORIBOGAINE
    Publication number: 20130165425
    Abstract: Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 27, 2013
    Applicant: DEMERX, INC.
    Inventor: DemeRx, Inc.
  • Substituted noribogaine
    Patent number: 8362007
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: January 29, 2013
    Assignee: Demerx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty
  • Noribogaine in the treatment of pain and drug addiction
    Patent number: 8178524
    Abstract: The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment should be supplemented with the administration of an opioid antagonist such as naloxone.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: May 15, 2012
    Assignee: Demerx, Inc.
    Inventor: Deborah C. Mash