Patents Assigned to Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
  • Conjugate comprising a folic acid antagonist and a carrier
    Patent number: 6720304
    Abstract: The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: April 13, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
    Inventors: Hannsjörg Sinn, Hans-Herman Schrenk, Wolfgang Maier-Borst, Eva Frei, Gerd Stehle
  • Contour collimator for use in radiotherapy
    Patent number: 6711237
    Abstract: A contour collimator for radiation therapy has a plurality of diaphragm elements that are movable with respect to each other by means of drive units. The diaphragm elements of the invention are supported only on the side near the drive units for ease of movement. This allows larger contour collimators to be constructed having relatively heavy diaphragm elements while retaining relatively small motors.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: March 23, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Wolfgang Schlegel, Otto Pastyr, Gernot Echner, Karl-Heinz Hover, Jurgen Richter
  • Conjugate for treating inflammatory infectious and/or skin diseases
    Patent number: 6706713
    Abstract: This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: March 16, 2004
    Assignees: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Hansjörg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Gerd Stehle
  • Mutant DEDD proteins for regulating apoptosis
    Patent number: 6696547
    Abstract: The invention relates to a protein for regulating apoptosis and to a nucleic acid encoding the protein. The protein and nucleic acids are useful in the regulation of apoptosis, and in methods for diagnosing or detecting apoptosis. The invention also relates to antibodies directed against the protein.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: February 24, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Marcus Peter, Peter Krammer
  • Method for the light-controlled synthesis of biochips
    Patent number: 6673544
    Abstract: The present invention relates to a method for the photolithographic synthesis of biochips in which photolabile protective groups of the 2-(2-nitrophenyl)ethyl type are used, whereby the irradiation step that is common in the photolithographic chip synthesis is carried out in the presence of a base, preferably a secondary or uerriary base.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: January 6, 2004
    Assignee: Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
    Inventors: Markus Beier, Stefan Matysiak, Jorg Hoheisel
  • Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
    Patent number: 6610303
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the papilloma virus genome and antibodies directed against them as well as their use for diagnosis, treatment and vaccination.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: August 26, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Ethel-Michele de-Villiers-zur Hausen, Harald zur Hausen, Donna Lavergne, Claire Benton
  • Method for detecting an element in a sample
    Patent number: 6586735
    Abstract: A method for detecting an element in a sample using a transmission electron microscope to measure a first image of the intensities of the sample at an energy loss in the range of the element signal. The background at various points is determined in a comparator sample which does not contain the element intensity. Energy loss is determined at the front of the element signal, and an energy loss is determined in the range of the element signal. From these values an approximation function is calculated so that an image of the pure element-specific intensities can be calculated.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: July 1, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts
    Inventors: Ansgar Haking, Karsten Richter
  • Method of sequencing by oligomer hybridization
    Patent number: 6562566
    Abstract: The present invention relates to a method of sequencing DNA by oligomer hybridization, DNA/RNA hybrid oligomers applied onto a support and optionally DNA oligomers and/or RNA oligomers being used as hybridization matrix.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: May 13, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventor: Jörg Hoheisel
  • Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
    Patent number: 6562597
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof for diagnosis, treatment and vaccination.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: May 13, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
  • Method for enhancing the contrast for a transmission electron microscope
    Patent number: 6563112
    Abstract: The intention is to provide a process for the contrast enhancement of a specific particle in an image of a specimen, taken by a transmission electron microscope, in which a calculated contrast-rich image is created by way of the background intensities calculated from the intensities of a first image being drawn off pixel by pixel, whereby the background intensities are calculated as a function of the intensities of a second image. In this situation, it is intended that this process should feature a higher range of application than processes known hitherto, and, in particular, are well-suited for contrast enhancement for gold particles in immuno-gold marking.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: May 13, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts
    Inventors: Ansgar Haking, Helmut Tröster, Karsten Richter, Michael Trendelenburg
  • Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
    Patent number: 6555345
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof for diagnosis, treatment and vaccination.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: April 29, 2003
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
  • Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
    Patent number: 6488935
    Abstract: The present invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. Furthermore, the present invention concerns proteins coded by the papilloma virus genome and antibodies directed thereagainst as well as the use thereof for diagnosis, treatment and vaccination.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: December 3, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Ethel-Michelle De Villiers Zur Hausen, Harald Zur Hausen
  • Phagemid for antibody screening
    Publication number: 20020160463
    Abstract: A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small quantities of antigen. The antibody-pIII gene can be strongly repressed, so that it allows antibody libraries to be amplified without the danger of deletion mutants predominating. After induction, large quantities of the fusion protein may be expressed.
    Type: Application
    Filed: April 8, 2002
    Publication date: October 31, 2002
    Applicant: Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
    Inventors: Frank Breitling, Melvyn Little, Stefan Dubel, Michael Braunagel, Iris Klewinghaus
  • Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
    Publication number: 20020110865
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof for diagnosis, treatment and vaccination.
    Type: Application
    Filed: January 23, 2002
    Publication date: August 15, 2002
    Applicant: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
  • Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
    Publication number: 20020110866
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof for diagnosis, treatment and vaccination.
    Type: Application
    Filed: January 23, 2002
    Publication date: August 15, 2002
    Applicant: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts.
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
  • Protein for regulating apoptosis
    Publication number: 20020099009
    Abstract: The invention relates to a protein for regulating apoptosis and to a nucleic acid encoding the protein. The protein and nucleic acids are useful in the regulation of apoptosis, and in methods for diagnosing or detecting apoptosis. The invention also relates to antibodies directed against the protein.
    Type: Application
    Filed: December 8, 2000
    Publication date: July 25, 2002
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS
    Inventors: Marcus Peter, Peter Krammer
  • Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
    Patent number: 6413522
    Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. Furthermore, this invention concerns proteins coded by the papilloma virus genome and antibodies directed thereagainst as well as the use thereof for diagnosis, treatment and vaccination.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: July 2, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen, Donna Lavergne, Claire Benton
  • Individual medicament dosing conjugate
    Patent number: 6410695
    Abstract: The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the preparation of such a conjugate and its use.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: June 25, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts
    Inventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle
  • Conjugate comprising an active agent, a polypeptide and a polyether
    Patent number: 6395254
    Abstract: The present invention relates to conjugates, comprising an active substance, a polypeptide and a polyether, a process for the production of such conjugates as well as their use.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: May 28, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle, Heinz H. Fiebig
  • DNA coding for a peptide of a papilloma virus main capside protein and use thereof
    Patent number: 6395512
    Abstract: This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof and the use thereof in diagnosis, treatment and vaccination.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: May 28, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Irene Leigh, Harald Zur Hausen