Abstract: Described are DNA sequences encoding an E6 or E7 fusion protein of HPV, wherein said DNA sequences are characterized by a combination of the following features: original codons are exchanged by codons which lead to an enhanced translation in a mammalian cell, they contain a deletion resulting in the production of a truncated non-functional protein, and they encode a fusion partner which is a highly immunogenic polypeptide capable of enhancing the immunogenicity of the E6 or E7 protein in the mammalian host. Furthermore, the modified E6 or E7 protein encoded by said DNA sequences as well as expression vectors containing said DNA sequences are described as well as several uses of the these compounds.
Type:
Grant
Filed:
April 10, 2007
Date of Patent:
April 20, 2010
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Abstract: An embodiment is directed to a method and a system for assisting the targeting of a target with an elongate instrument, wherein the instrument is to be inserted into a living object's body part along a predetermined trajectory extending between an entry point of said instrument into said body part and a target point associated with said target. The method comprises an instrument directing assisting step for generating and displaying an image allowing a user to assess to which extend the longitudinal axis of the instrument is aligned with the vector connecting the target point and the tip portion of said instrument. Also, the method comprises an instrument guiding assisting step of generating and displaying an image allowing a user to assess to which extent the instrument motion during insertion thereof coincides with the predetermined trajectory.
Type:
Application
Filed:
June 10, 2009
Publication date:
March 25, 2010
Applicant:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Inventors:
Lena Maier-Hein, Alexander Seitel, Ivo Wolf, Hans Peter Meinzer
Abstract: A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
Type:
Grant
Filed:
October 2, 2007
Date of Patent:
March 2, 2010
Assignees:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts, Mor Research Applications, Ltd.
Abstract: The present invention provides a composition comprising (a) a parvovirus NS1 protein and (b) a parvovirus VP1 protein. Furthermore, the present invention provides DNA sequences encoding said proteins. The composition of the invention is useful for the preparation of a toxin for treating tumoral diseases.
Type:
Application
Filed:
September 30, 2009
Publication date:
February 4, 2010
Applicant:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Inventors:
Laurent Daeffler, Jurg Nuesch, Jean Rommelaere
Abstract: The present invention relates to a process for linking two molecules by means of a Diels Alder reaction with inverse electron requirement (DARinv), comprising the following steps: reaction of a (a) triazine or tetrazine with one or more electron-attracting substituents on the ring as a diene component, the electron-attracting substituents being selected from: COOR C(O)NR2 CX3 (X=halogen) halogen CN SO2—R or SO3—R PR2 wherein R?H, alkyl, aryl, heterocycle, which in turn may be substituted, where appropriate, with alkyl, OH, SH, halogen, aryl, heterocycle, nitro, carboxyamido or amine group.
Type:
Application
Filed:
June 18, 2007
Publication date:
January 21, 2010
Applicant:
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS
Inventors:
Manfred Wiessler, Eduard Müller, Peter Lorenz, Christian Kliem, Heinz Fleischhacker
Abstract: The present invention relates to a database storage structure for the storage of a plurality of results from an experiment on a sample. The database storage structure includes a result storage table for storing the results from the experiment, one or more first annotation storage tables for storing a first set of variables, and one or more second annotation storage tables for storing a second limited set of variables. The one or more second annotation storage tables are further coupled to one or more concordance tables for storing a concordance between the second limited set of variables and a second list of annotations.
Type:
Grant
Filed:
October 2, 2002
Date of Patent:
January 19, 2010
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Abstract: A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
Type:
Grant
Filed:
July 10, 2001
Date of Patent:
November 17, 2009
Assignees:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts, Mor Research Applications, Ltd.
Abstract: The present invention relates to a cell culture medium comprising (a) an inhibitor of bone morphogenetic protein-4 (BMP-4) and (b) an inhibitor of pigment epithelium-derived factor (PEDF, also known as SerpinF1). In one embodiment, the inhibitors are antibodies against BMP-4 and PEDF, respectively. The medium allows to culture keratinocytes under non-differentiating conditions. The invention also relates to corresponding methods and kits. As the media and methods disclosed allow for an improved manufacture of keratinocytes, the invention also relates to the treatment of skin wounds and to the manufacture of corresponding medicaments. This will be of advantage for treatment e.g. of burns, ulcers, etc., in which transplantation of keratinocytes or skin is required.
Type:
Application
Filed:
September 7, 2007
Publication date:
November 12, 2009
Applicant:
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
Inventors:
Axel Szabowski, Peter Angel, Julia Knebel
Abstract: The present invention relates to an antibody active against a fusion polypeptide comprising a histidine portion, a process for the preparation thereof and its use.
Type:
Application
Filed:
May 14, 2009
Publication date:
September 3, 2009
Applicant:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Abstract: The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of HIV. The conjugates comprise the following components: (a) a transport mediator for the cell membrane, (b) an address protein or peptide for the import into the cell nucleus, and (c) a peptide nucleic acid (PNA) which is to be transported and can be hybridized with an HIV gene and can inhibit the expression of the HIV gene.
Type:
Grant
Filed:
July 12, 2002
Date of Patent:
July 21, 2009
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Abstract: Described is a novel type II ribosome-inactivating protein, riproximin, as well as nucleic acid molecules encoding said protein. Furthermore, therapeutic uses of riproximin are described.
Type:
Application
Filed:
February 6, 2006
Publication date:
May 28, 2009
Applicant:
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
Inventors:
Cristina Voss, Martin Berger, Carlos Schumacher
Abstract: Described is a diagnostic conjugate comprising (a) a transmembrane module (TPU), (b) an address module (AS), preferably an antisense peptide nucleic acid (PNA), and (c) a signaling module (SM). The conjugate is useful for intracellular imaging, preferably via MRI, and, e.g., for differentiating between tumor- and non-tumor cells.
Type:
Grant
Filed:
January 22, 2003
Date of Patent:
May 12, 2009
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
Inventors:
Klaus Braun, Jürgen Debus, Jürgen Jenne, Rudiger Pipkorn, Ralf Rastert, Waldemar Waldeck, Isabell Braun, Stefan Heckl
Abstract: The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a biological system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights wj within the target.
Type:
Application
Filed:
February 2, 2007
Publication date:
March 5, 2009
Applicant:
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
Abstract: The invention relates to a dual-modality imaging system and a method for dual-modality imaging, wherein a positron emission tomography (PET) scanner for acquiring PET imaging data and at least one optical imaging detector for acquiring optical imaging data are arranged to acquire the PET imaging data and the optical imaging data of an imaged object (5) simultaneously (i.e. at the same time and at superimposed fields-of-view). The at least one optical imaging detector is a non-contact optical imaging detector.
Type:
Application
Filed:
April 10, 2006
Publication date:
February 12, 2009
Applicant:
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts
Abstract: The invention relates to an optical imaging detector for fluorescence and bioluminescence imaging of an imaged object that can be used for tomographic imaging. The optical imaging detector comprises at least one micro-lens array with a plurality of micro-lenses. A photo detector can be located either in the focal plane of the micro-lens array or can be connected to the micro-lens array by a network of optical fibres and be located externally.
Type:
Application
Filed:
April 10, 2006
Publication date:
February 5, 2009
Applicant:
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
Inventors:
Jorg Peter, Ralf Schulz, Daniel Unholtz
Abstract: The invention relates to a conjugate for treating prokaryotic infections from a transport mediator penetrating the prokaryotic cell membrane and a desired compound to be introduced into the prokaryote and directed thereagainst, which compound is preferably a peptide nucleic acid (PNA) directed against a gene of the prokaryote giving antibiotic resistance.
Type:
Grant
Filed:
January 17, 2003
Date of Patent:
January 13, 2009
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Inventors:
Klaus Braun, Isabell Braun, Jürgen Debus, Rudiger Pipkorn, Waldemar Waldeck
Abstract: A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
Type:
Application
Filed:
October 2, 2007
Publication date:
June 12, 2008
Applicants:
Mor Research Applications, Ltd., Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Abstract: A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.
Type:
Grant
Filed:
February 13, 2004
Date of Patent:
April 8, 2008
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts
Inventors:
Lutz Gissmann, Kai Pohlmeyer, Martin Müller
Abstract: This invention relates to a parvovirus vector having a parvovirus DNA excisable from the vector DNA in a parvovirus-permissive cell, the parvovirus DNA having a left terminus which comprises a parvovirus minimal origin of replication, and a system comprising the parvovirus vector. Furthermore, this invention concerns a method of producing the parvovirus vector, parvoviral particles as well as their use.
Type:
Grant
Filed:
October 14, 1999
Date of Patent:
September 11, 2007
Assignees:
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts, Yale University
Abstract: Described are DNA sequences encoding an E6 or E7 fusion protein of HPV, wherein said DNA sequences are characterized by a combination of the following features: original codons are exchanged by codons which lead to an enhanced translation in a mammalian cell, they contain a deletion resulting in the production of a truncated non-functional protein, and they encode a fusion partner which is a highly immunogenic polypeptide capable of enhancing the immunogenicity of the E6 or E7 protein in the mammalian host. Furthermore, the modified E6 or E7 protein encoded by said DNA sequences as well as expression vectors containing said DNA sequences are described as well as several uses of the these compounds.
Type:
Application
Filed:
April 10, 2007
Publication date:
August 23, 2007
Applicant:
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts