Abstract: A method for reconstructing a secret, over a public communication channel, using a perfect t-out-of-n secret sharing scheme. The scheme having a dealer which utilizes a delivering procedure for privately delivering n secret shares of the secret along with n keys to n participants that are interlinked by the channel. The scheme further having a secret reconstructing procedure for being executed by selected recipient participants, for reconstructing the secret by utilizing self secret share of the recipient participant and l-1 secret shares of the other participants. The secret reconstructing procedure includes the following steps:(i) receiving over said public communication channel l-1 encoded secret shares from the l-1 participants, respectively;(ii) decoding each one of the l-1 encoded secret shares, thereby obtaining l-1 decoded secret shares; and(iii) reconstructing the secret from the l-1 decoded secret shares and from the self secret share of the recipient participant.
Type:
Grant
Filed:
August 21, 1996
Date of Patent:
June 9, 1998
Assignee:
Technion Research and Development Foundation Ltd.
Abstract: The present invention provides an inhibitor of monoamine oxidase comprising a modified synthetic flavin adenine dinucleotide compound. Also provided is a method of inhibiting monoamine oxidase enzymatic activity in a cell, comprising the step of contacting said cell with a pharmacologically effective dose of a modified synthetic flavin adenine dinucleotide compound. Further provided is a method of treating a brain pathophysiological state in an individual, comprising administering a therapeutically effective dose of a modified synthetic flavin adenine dinucleotide compound to said individual.
Type:
Grant
Filed:
May 24, 1995
Date of Patent:
May 26, 1998
Assignee:
Research Development Foundation
Inventors:
Creed W. Abell, Sau-Wah Kwan, Binhua Zhou, Blain M. Mamiya, Duane A. Lewis
Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
Type:
Grant
Filed:
May 22, 1995
Date of Patent:
April 28, 1998
Assignees:
Teva Pharmaceutical Industries, Ltd., Technion Research and Development Foundation Ltd.
Inventors:
Moussa B. H. Youdim, John P. M. Finberg, Ruth Levy, Jeffrey Sterling, David Lerner, Haim Yellin, Alex Veinberg
Abstract: A method for the recovery of fugitive volatile organic vapors which comprises the steps of: (a) compressing said vapors to a pressure of at least 200 kpa; (b) feeding the hot compressed vapors to the desorption step of a Heat-Mass-Exchange (HME) system; (c) cooling the effluent resulted from the desorption step to the ambient temperature and separating out the condensed liquid obtained and (d) feeding the residual cold vapor phase, after the separation of the condensed liquid, to the adsorption step of said HME system, thus recovering the fugitive organic vapors. According to a preferred embodiment, the compressed vapors resulted from step (b) are at a temperature in the range of between 80.degree. to 150.degree. C., which may be reached by an external heating and the effluent resulted from the desorption step (c) is cooled at a temperature of about 5.degree. C.
Type:
Grant
Filed:
January 23, 1995
Date of Patent:
April 21, 1998
Assignees:
Ram Lavie, Technion Research and Development Foundation Ltd.
Abstract: In accordance with the present invention, there are provided novel homeobox-type pancreatic islet transcription factor proteins useful to bind to tissue-specific elements (TSEs) within a pancreatic islet hormone gene promoter and modulate hormone gene expression both in vivo and in vitro. Nucleic acid sequences encoding such transcription factor proteins and assays employing same are also disclosed. The invention transcription factor proteins can be employed in a variety of ways, for example, to modulate RNA transcription, for production of antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies.
Abstract: Methods for determining the flow rate of a substance within an object by extracting and mathematically manipulating numerical parameters from a thermoimaging temperature response curve of the surface of the object. The methods of the present invention are suitable to determine coronary arteries flow rates and myocardial perfusion rates in open chest conditions.
Type:
Grant
Filed:
September 7, 1995
Date of Patent:
December 2, 1997
Assignee:
Technion Research And Development Foundation Ltd.
Inventors:
Naama Gordon, Rafael Beyar, Samuel Sideman
Abstract: A method and apparatus for fixing images, holograms and domain gratings in crystals by application of an electric field on a crystal and simultaneous illumination of it with a light pattern. The fixing procedure is based on a screening effect. The modulation of the domains may be perpendicular to the c-axis. Another application of the method is in frequency mixing such as second harmonic generation and parametric processes, by overcoming the problem of phase matching using the domain gratings. Thus, it is possible to obtain controllable broadband mixing and tailored quasi-phase matching for several wavelengths or for prespecified wavelength tuning ranges and frequency widths.
Type:
Grant
Filed:
October 17, 1995
Date of Patent:
November 25, 1997
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: A converter for use with a constant speed vehicle cruise control system including a speedometer for generating a self speed signal representative of the self speed of the vehicle and a speed adjustment control responsively coupled to the speedometer for maintaining the self speed of the vehicle at a preset speed. The converter adapts the control system to a constant distance system, and comprises a rangefinder for generating a distance signal corresponding to the distance of the vehicle from a front vehicle, and a distance-dependent speed adjustment device coupled to the rangefinder and to the speedometer for generating a synthetic-speed signal corresponding to the set speed required for maintaining a predetermined distance between the two vehicles. A selector switch allows either the self speed or synthetic-speed signals to be connected to the speedometer of the cruise control system.
Type:
Grant
Filed:
April 18, 1995
Date of Patent:
November 18, 1997
Assignee:
Technion Research and Development Foundation Ltd.
Abstract: The present invention provides a method of identifying immunocompromised individuals who are at high risk for development of cryptococcosis, comprising the step of measuring the levels of IgG antibody to glucuronoxylomannan in the sera of said individuals. Also provided are various methods of detecting antibody to glucuronoxylomannan in sera and a kit for assaying the presence of antibody to glucuronoxylomannan in the sera of immunocompromised individuals.
Abstract: The present invention provides a novel isolated and purified protein that is produced by brain endothelial cells, has a molecular weight of approximately 67 kDa of SDS-PAGE, with the protein being capable of stimulating proliferation of cerebral arteriole smooth muscle cells. Also provided are various methods of using this novel protein or the gene encoding this protein, including methods of treating various cerebrovascular diseases.
Type:
Grant
Filed:
May 9, 1994
Date of Patent:
October 14, 1997
Assignee:
Research Development Foundation
Inventors:
Frank M. Yatsu, Nargis A. Alam, Syed S. Alam
Abstract: The invention relates to a preparation exhibiting enzymatic activity, which preparation has the capability of delignifying wood pulp at a temperature of at least 65.degree. C. and a pH of at least 9. Further, the invention relates to a method of producing said preparation by aerobically fermentating a selected Bacillus stearothermophilus strain. Furthermore, the invention relates to two isolated Bacillus stearothermophilus strains and mutants and variants thereof. The invention also relates to applications of the preparation of the invention, namely to a process comprising treatment of wood pulp with a preparation according to the invention, and a wood pulp and a fluff pulp treated with a preparation according to the invention, and also a paper, a board and a fluff made from a wood pulp treated with a preparation according to the invention.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
October 14, 1997
Assignees:
Korsnas Aktiebolag, The Technion Research and Development Foundation Ltd., Ramot-University Authority for Applied Research and Industrial Development Ltd.
Abstract: The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having the structure formula ##STR1## wherein m is 0 to 3, n is 0 to 4 when Het is nitrogen, wherein R is selected from the group consisting of hydrogen, alkyl, arylmethyl and acyl; R.sup.1 is alkyl; R.sup.2 is selected from the group consisting of hydrogen and alkyl; R.sup.3 is selected from the group consisting of alkyl and acyl when Het is nitrogen, R.sup.4 is selected from the group consisting of hydrogen and alkyl; R.sup.5 is selected from the group consisting of hydrogen and alkyl; and R.sup.6 and R.sup.7 are selected from the group consisting of hydrogen, alkyl and R.sup.6 and R.sup.7 together may represent oxygen. Also provided are various methods for the treatment of a pathological cell proliferative disease comprising administering to an animal) a pharmacologically and therapeutically effective dose of a pharmaceutical composition comprising a p-heteroatom-substituted phenols or an analog thereof.
Type:
Grant
Filed:
January 20, 1995
Date of Patent:
October 7, 1997
Assignee:
Research Development Foundation
Inventors:
John C. Gilbert, Kimberly Kline, Kathiresan Krishnan, Maria Simmons Menchaca, Marian Pinto, Robert G. Sanders
Abstract: A method for the digital frequencey domain implementation of receiving arrays. The steps of the method are as follows: a discrete time input signal is transformed into its spectral components and the redundant spectral components are removed. Products of the non-redundant spectral components with a scaled set of acquired weights are computed. From the so-computed products a first set of spectral sums is calculated wherefrom a second set of spectral sums is derived. Thereafter, the first and second sets of spectral sums are converted to the discrete time domain thereby obtaining a discrete time output signal. The invention also provides a system having receiving components operating in accordance with the method. In another embodiment the invention also provides a method and system for the digital frequency domain implementation of transmitting arrays.
Type:
Grant
Filed:
July 6, 1995
Date of Patent:
September 23, 1997
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: An automated furrow irrigation control method and system involves the initiation of an irrigation flow into an upstream end of a furrow at an initial water discharge rate; continuously or periodically sensing the progress of water flow along the furrow; continuously or periodically increasing the water discharge rate in response to the sensed progress of the water flow so as to ensure a substantially continuous flow in the furrow at a flow rate which lies substantially between .+-.30% of a constant value; sensing the arrival of the water flow at a downstream end of the furrow; reducing the water discharge rate in response to the sensed arrival of the water flow at the downstream end of the furrow; sensing the percolation of the water flow at the downstream end down to a predetermined depth; and terminating the irrigation flow in response to the sensed percolation.
Type:
Grant
Filed:
June 19, 1995
Date of Patent:
September 16, 1997
Assignee:
Technion Research and Development Foundation
Abstract: A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid. Also provided is a method of inhibiting tumor necrosis factor receptors using retinoic acid-like compounds.
Abstract: The present invention provides novel methods of treating anti-neoplastic and non-neoplastic cell proliferative diseases. The present methods involve administration of triplex forming oligonucleotides to humans to inhibit the biological activity of tumor necrosis factor. Also provided are methods of treating neuro-oncologic states and renal cancer.
Type:
Grant
Filed:
June 6, 1994
Date of Patent:
July 22, 1997
Assignee:
Research Development Foundation
Inventors:
Bharat B. Aggarwal, Robert F. Rando, Michael E. Hogan
Abstract: The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against vital reverse transcriptase. Also provided are various methods of using this novel including methods of treating various diseases.
Abstract: A method of using a distributed saturable absorber added to a laser cavity, which by nonlinear wave-mixing of the counterpropagating beams (or spatial hole-burning) promotes a reduction of the linewidth and a single mode operation.
Type:
Grant
Filed:
March 21, 1995
Date of Patent:
July 8, 1997
Assignee:
Technion Research & Development Foundation Ltd.
Inventors:
Baruch Fischer, Ron Daisy, Moshe Horowitz
Abstract: This invention relates to substantially purified gelonin, toxic fragments thereof, the DNA sequences encoding gelonin and use of the DNA for producing, by recombinant technology, gelonin, toxic fragments thereof and fusion proteins. More specifically, the invention relates to the primary amino acid sequence of gelonin, and of the DNA encoding said gelonin and the production of synthetic gelonin and toxic fragments thereof.
Type:
Grant
Filed:
June 6, 1994
Date of Patent:
May 20, 1997
Assignee:
The Research Development Foundation
Inventors:
Michael Rosenblum, William J. Kohr, Bharat Aggarwal