Abstract: The present invention provides the nucleotide sequence for a synthetic gene for the plant toxin gelonin and a process for producing, cloning and expressing this synthetic gene. The DNA sequence for a synthetic gene for gelonin as shown in sequence ID NO. 1. The present invention also provides expression vectors containing the DNA sequences for gelonin and cells transformed with these vectors. In addition, an immunotoxin comprising an antibody of conjugated to the protein gelonin.

Abstract: An eye imaging system having a hand held portable image capture unit connected by cable to a housing. The hand held unit includes a light fiber optic for transmitting light to the eye, imaging and focusing optics, and a charge coupled image device. The connecting housing provides an electrical power source, light source and viewing monitor for viewing an image of the eye.

Abstract: A method for producing a photodiode with a simplified planar device architecture based on a single layer of HgCdTe using a mature, established growth technology for the sensing material, combined with an implanted homojunction which is at least partially activated during MOCVD CdTe passivation. The device architecture is based on a planar structure, a p-on-n homojunction for sensing the infrared radiation, and a CdTe or CdZnTe/HgCdTe heterostructure for passivation. The MOCVD CdTe passivation can be applied ex-situ, irrespective of the growth technology of the sensing material, and the homojunction is at least partially activated while applying the CdTe passivation. Thus, a major simplification in device architecture is achieved, based on a single layer in contrast to known, double layer heterostructures.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

Abstract: R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.

Abstract: The present invention provides a method of inhibiting the proliferation of smooth muscle cells comprising the step of contacting said cells with a pharmacologically effective amount of sodium butyrate.

Abstract: The invention relates to the use of an organic extract of the plant Cinnamon or a chemical constituent present in said plant, to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. Most preferred chemical constituents are cinnamaldehyde and methoxycinnamaldehyde. The extract may be used either as a drink, with or without additional flavoring ingredients or transformed into a capsule. The invention also relates to in-vitro method for determininig the inhibition of urease activity of Helicobacter pylori using said organic extract of the plant or chemical constituents present in said plant.

Abstract: An improved method for diagnosing myofibrogranuloma (MFG) in walleye without harming the fish is described. Blood samples are drawn from walleye and creatinine and calcium levels are then determined along with the sex and length of the fish. These data are then analyzed and compared to data from healthy walleye using discriminant analysis. The process is effective for identifying approximately 88% of MFG-positive walleye.

Abstract: A process for the removal of species containing metallic ions from effluents by yeast cell walls. The yeasts used are selected from Saccharomyces cerevisae, Saccharomyces uvarum and Saccharomyces lipolytica. According to the process, the washed yeast cell walls are first treated by a water soluble aldehyde and after sorbing the metallic ions, the yeast cell walls may regenerated by a mineral acid or a chelate solution such as ethylene-diamine tetraacetic acid, releasing the sorbed metal ions. According to a preferred embodiment, water containing acetone or alcohol is used for washing the yeast cell walls. The sorption by the yeast cell walls is carried out at a pH in the range of 1 to 13 and preferably in the range of 4 to 7. The most preferred aldehyde is selected from formaldehyde and glutaraldehyde or any mixture thereof. The metal sorption process may be carried out batchwise or continuously. In the continuous process, the yeast cell walls are immobilized on porous glass, purified sand or polymers.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

Abstract: The present invention provides a composition of matter, comprising a non-infectious, mutated virus suitable for use in preparing a vaccine. A plasmid adapted for expression in a recombinant cell comprising DNA encoding non-infectious mutated virus protein and regulatory elements necessary for expression of said DNA in the cell. Also provided are methods of inhibiting the spread of infection of a virus comprising the step of contacting said virus with a compound that inhibits thiol-reductase/protein disulfide isomerase activity in said virus.

Abstract: A stapler device includes a manually grippable handle containing a drive and a trigger to activate the drive mechanism, a barrel fixed to the handle, a guide for holding a staple to be ejected and formed to accommodate a suture thread fixed to the staple, and an ejector driven by the drive through the barrel for ejecting a staple out through the guide into a bone to enable the suture, so anchored to the bone, to be used for various medical operations.

Abstract: The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

Abstract: The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of COOCH.sub.3, COOC.sub.2 H.sub.5, H, COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 and are free from amino, nitro, chloride and fluoride groups. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e., electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC.sub.50 [M] values.

Abstract: A method and apparatus for analyzing the electrical activity of the heart by Body Surface Potential Mapping (BSMP) in which an array of electrodes are applied over the thoracic region of a subject's body for producing measurements of the electrical signals generated in the thoracic region, and the measurements are processed for indicating certain electrical events in the subject's body. The array of electrodes are utilized to measure only the times of crossing of the electrical signals over a preset threshold.

Abstract: The invention relates to the use of either an aqueous extract or an organic extract of the plant Thymus to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. In case of an aqueous extract, a minimum amount of 0.5 mg of the dry plant in the extract is required but the preferred amounts are above 1.2 mg. The aqueous extract may be used either as a drink, with or without additional ingredients, or transformed into a capsule or a paste. The invention also relates to in-vitro methods for inhibiting the growth of the urease activity of Helicobacter pylori.

Abstract: Color image enhancement apparatus comprising apparatus for receiving signals representing a color image, image processing apparatus, employing the received signals, for image processing of the high spatial frequency chromatic components of a color image, and apparatus for providing a color image from the output of said image processing apparatus.

Abstract: The antibody response to a target antigen may be enhanced by incorporating the antigen into a liposome along with an additional constituent which contains at least one T-helper lymphocyte recognition site. The liposomes can include a wide variety of lipid materials. Both the antigen and the T-helper lymphocite recognition site containing constituent may be associated with the liposome by using hydrophobic interactions or by covalent attachment to a lipid.

Abstract: A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid.

Abstract: R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.