Abstract: A system comprising: at least one hardware processor; and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a data stream representing events; receive a plurality of complex event patterns (CEPs) comprising (a) a set of conditions reflecting relations among said events, and (b) a set of attributes associated with each of said events; and calculate an optimal multi-pattern evaluation plan corresponding to said CEPs by: (i) generating an initial evaluation plan, (ii) applying a search method to calculate modified versions of said initial evaluation plan, (iii) assigning a score to each of said modified versions based on a cost function, and (iv) selecting one of said modified versions having a highest said score as said optimal multi-pattern evaluation plan.

Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.

Abstract: Disclosed are a music data analysis apparatus capable of analyzing and visualizing creation principles of music and a music data generation apparatus capable of using the creation principles. The music data generation apparatus may comprise: a memory; and a processor executing at least one instruction stored in the memory, wherein the processor is configured to perform: generating a seed overlap matrix so that the seed overlap matrix represents musical features of seed music data; and generating new music data based on the seed overlap matrix.

Abstract: A switchable display system for providing virtual reality or augmented reality using a color calibration display apparatus may comprise: an augmented reality data server configured to provide virtual reality and augmented reality information; and a color calibration display apparatus using a color calibration display module configured to perform color calibration according to ambient illuminance in a use environment.

Abstract: A circuit includes a first full adder, a second full adder, a first half adder, a third full adder configured to receive a sum output signal of the first full adder, a sum output signal of the second full adder, and a sum output signal of the first half adder, a fourth full adder configured to receive a carry output signal of the first full adder, a carry output signal of the second full adder, and a carry output signal of the first half adder, a second half adder configured to receive a carry output signal of the third full adder and a sum output signal of the fourth full adder, and a third half adder configured to receive a carry output signal of the second half adder and a carry output signal of the fourth full adder.

Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: The present invention relates to products and methods for modulating cardiac function.

Abstract: A device for learning a fog-invariant feature includes a fog-pass filter, which is trained such that fog factors of the same fog domain approach each other and fog factors of different fog domains are apart from each other so as to determine a fog state of an input image as a fog factor, and a segmentation network, which is trained such that a fog style gap between the different fog domains decreases, in which training of the fog-pass filter and training of the segmentation network are alternatively performed by using three fog domain datasets.

Abstract: Disclosed herein are a multi-level device which has a ternary characteristic and can reduce hysteresis, and a method of manufacturing the same. The multi-level device can have a plurality of turn-on voltages, that is, a plurality of threshold voltages, thereby providing multi-level conductivity as a ternary device characteristic. In addition, a double insulating layer made of a dielectric layer and an organic polymer layer is used as a separation layer for channel layer separation, and by removing the hysteresis due to a trap charge at an interface between a channel layer and an insulating layer, a uniform ternary characteristic can always be maintained, and by forming the channel layer on an organic polymer layer, the channel layer can be more stably formed on the insulating layer.

Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.

Abstract: An optical digital to analog converter (oDAC) that may include (a) multiple optical paths that are parallel to each other; (b) a combiner, (c) a splitter that is configured to receive an optical signal at a splitter input and split the optical signal between multiple splitter outputs to provide multiple path input signals to the multiple optical paths. The multiple optical paths are configured to optically process, in parallel, path input signals to provide path output signals. Each optical path is configured to apply an optical process that comprises applying optical modulation, by an optical gate of the optical path and under a control of an electrical modulator, to provide an optical signal having a value selected out of multiple constellation levels. The combiner is configured to add the multiple path output signals to provide an oDAC output signal having a value selected from values of a single quadrature constellation.

Abstract: The invention provides metal-peptoid complexes for use as electrocatalyst in water oxidation processes.

Abstract: The current disclosure provides for methods for differentiating stem and progenitor cells into neural cells through an approach that excludes the use of SMAD or Noggin inhibition. Aspects of the disclosure relate to a method for differentiating stem or progenitor cells into neural cells, the method comprising contacting the cells with a compound selected from DMH1, DMH2, K02288, A8301, or combinations thereof.

Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.

Abstract: An airfoil surface skin, comprising a network of a solid material, embedded in a base of deformable solid material. Fluid pressure applied to the interface between the network and the surrounding embedding material, opens an internal network of channels by viscous peeling of the surrounding solid from the network. The network is offset from the centerline the surround material, such that pressure driven viscous flow through the narrow channels generates two types of deformation of the skin—an in-plane elongation and a curvature of the skin plane itself. The shape of the internal solid core element and its material, and the material of the encompassing solid are chosen to achieve a desired integral structural rigidity. The injected fluid pressure determines the extent of extension and bending. Use of this skin enables shape amending airfoils having reduced drag compared with similar airfoils having conventional flap mechanisms.

Abstract: A blood glucose control system according to an embodiment of the present invention includes a continuous blood glucose meter configured to continuously measuring blood glucose of a patient, a bio-signal sensor configured to acquire a bio-signal of the patient, a lifelog data collector configured to collect lifelog data of the patient, an insulin injection controller configured to determine an insulin injection amount and an injection rate based on one or more of blood glucose measurement information and blood glucose metabolism characteristic information received from the continuous blood glucose meter, the bio-signal acquired by the bio-signal sensor or a stress level of the patient indexed by the bio-signal, and the lifelog data collected by the lifelog data collector, and an insulin pump configured to inject insulin into a body of the patient according to the insulin injection amount and the injection rate determined by the insulin injection controller.

Abstract: The present invention discloses a scintillator structure and to a method for producing an output optical signal at a specific wavelength range. The scintillator structure comprises a multilayer nanostructure formed by at least one pair of alternating first and second layered material being arranged along one or more principal axes. The multi-layer nanostructure defines predetermined geometrical parameters and the structure is made of at least two different material compositions. At least one of the first layered material, the second layered material, or the combination of both, define scintillation properties. The invention also discloses a detector system for detecting an input radiation comprising a scintillator structure being as defined above and being configured and operable to collect most of the emitted optical signal.

Abstract: Disclosed are a nanostructure including a nanoparticle, and a first compound including a probe and bound to the surface of the nanoparticle, a second compound including a DNA sequence encoding the probe and bound to the surface of the nanoparticle, and optionally substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, wherein when the nanostructure does not include substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, a ratio ((n1+n2)/w) of the sum of the number of moles (n1) of the first compound and the number of moles (n2) of the second compound relative to the weight (w) of the nanostructure is about 1.2 nmol/g to about 85 ?mol/g on average, a biosensor including the nanostructure, and a method of screening a biological material using the nanostructure or the biosensor.

Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.

Abstract: The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyl-transferase (SHMT)1. If the level of RFC or FPGS in the cancer cells is above the threshold value, the cancer is treated with an inhibitor of SHMT2.