Abstract: An orthogonal frequency division multiplexing (OFDM) transmitter that includes an encoder, an interleaver, a symbol processor; and a transmission module; wherein the encoder is configured to encode a superframe to provide an encoded superframe; wherein the encoded superframe comprises a sequence of encoded frames; wherein the interleaver is configured to allocate multiple frequency sub-bands to each encoded frame of the encoded superframe by assigning adjacent frequency sub-bands to successive symbols of each encoded frame; wherein the symbol processor is configured to generate, for each encoded frame and according to the assignment of the multiple frequency sub-bands, an intermediate set of symbols; and wherein the transmission module is configured to transmit simultaneously, for each encoded frame, OFDM symbols that represents the intermediate set of symbols.

Abstract: A system and method for generating hydrogen gas from an aqueous solution are disclosed herein. The system comprises a compartment with a working electrode for reducing water in response to an applied voltage to generate hydrogen and a redox-active electrode capable of reversibly undergoing oxidation and reduction. The system may further comprise a second compartment with a working electrode for generating oxygen and redox-active electrode electrically connectable to the redox-active electrode in the first compartment. The method comprises applying a voltage between a working electrode and a redox-active electrode of a system described herein and/or between comprising a working electrode of one compartment and a working electrode of a second compartment of a system described herein.

Abstract: A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In certain aspects, a method for identifying and treating JAM-C positive B-cell lymphoma patients with anti-JAM-C antibodies is provided. Recombinant antibody molecules that specifically bind to JAM-C are also disclosed.

Abstract: The present invention provides a composition having an interior hydrophobic space encapsulated by at least one non-derivatized cellulose molecular layer surrounded by a hydrophilic medium. The invention also provides methods for making an oil-in-water dispersion or water-in-oil dispersion by mixing a hydrophilic medium, a hydrophobic composition and non-derivatized cellulose solution in an ionic liquid or pure non-derivatized cellulose hydrogel.

Abstract: A modular platform unit comprising a plurality of sensors for the combined sensing of pressure, temperature and humidity. In particular, the sensors are composed of a layer of metallic-capped nanoparticles (MCNP) casted on a flexible substrate or a rigid substrate. Integration of the platform unit for artificial or electronic skin applications is disclosed.

Abstract: A method includes receiving from multiple transducers respective signals including reflections of a transmitted signal from a target. An image of the target is produced irrespective of sparsity of the received signals, by computing transducer-specific frequency-domain coefficients for each of the received signals, deriving, from the transducer-specific frequency-domain coefficients, beamforming frequency-domain coefficients of a beamformed signal in which the reflections received from a selected direction relative to the transducers are emphasized, and reconstructing the image of the target at the selected direction based on the beamforming frequency-domain coefficients.

Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc?RIIa, but that is significantly reduced for binding to the highly homologous Fc?RIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

Abstract: The present invention provides a semiconductor crystal comprising a semiconductor material having a tuned band gap energy, and methods for preparation thereof. More particularly, the invention provides a semiconductor crystal comprising a semiconductor material and amino acid molecules, peptides, or a combination thereof, incorporated within the crystal lattice, wherein the amino acid molecules, peptides, or combination thereof tune the band gap energy of the semiconductor material.

Abstract: A method of changing the volume of an intra-bilayer membrane space of at least one bilayer membranous structure of a target tissue. The method comprises providing at least one characteristic of a target tissue having at least one bilayer membranous structure, selecting an acoustic energy transmission pattern set to change a volume of an intra-bilayer membrane space of a bilayer membrane of the at least one bilayer membranous structure according to the at least one characteristic, and applying acoustic energy on the target tissue according to the selected acoustic energy transmission pattern.

Abstract: Methods and devices for purifying, detecting, and collecting analytes fractionated based on pI, separating analytes via electrophoresis and pI, and purifying a target molecule using pI focusing and subsequent crystallization are provided.

Abstract: Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant sortase serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity.

Abstract: A device that may include a narrowband filter that is arranged to pass radiation within a main signal waveband in which a muzzle flash is expected to include energy above a first energy threshold; a first single photon avalanche diode (SPAD) arranged to detect photons of the main signal waveband during different points in time and to output first digital detection signals representative of the photons of the main signal waveband; and a signal processor that is arranged to receive the first digital detection signals and to detect, in response to at least the first digital detection signals, the muzzle flash.

Abstract: A method of treating a bacterial infection in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide being between 3 and 5 amino acids, wherein at least one amino acid of the 3 and 5 amino acids is selected from the group consisting of tryptophan, cysteine, proline and methionine.

Abstract: Compositions and methods of treating an inflammatory disease in a subject are provided. Accordingly there is provided a method comprising administering to the subject a therapeutically effective amount of an agent which selectively inhibits activity and/or expression of iron regulatory protein (IRP) 1 and not IRP2, thereby treating the inflammatory disease in the subject. Also provided is a pharmaceutical composition comprising, as an active ingredient, an agent which selectively inhibits activity and/or expression of IRP1 and not IRP2, and a pharmaceutically acceptable carrier or excipient. Also provided are methods of identifying an agent that selectively modulates an activity of an IRP member of an IRP family of polypeptides and not of an additional IRP member of said IRP family of polypeptides.

Abstract: A device, comprising: an array of cells, wherein the cells are arranged in columns and rows; wherein each cell comprises a memristive device; an interfacing circuit that is coupled to each cell of the array of cells; wherein the interfacing circuit is arranged to: receive or generate first variables and second variables; generate memristive device input signals that once provided to memristive devices of the array will cause a change in a state variable of each of the memristive devices of the cells of the array, wherein the change in the state variable of each of the memristive devices of the cells of array reflects a product of one of the first variables and one of the second variables; provide the memristive device input signals to memristive devices of the array; and receive output signals that are a function of at least products of the first variables and the second variables.

Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].

Abstract: An add-on sling-load system capable of being attached to a host that comprises a load provided with at least two slices arrange in a predetermined configuration and preferably a stack and a controlled coupling mechanism configured to attach and release at least one slice from the arranged configuration. The sling load system is used for multiple devices.

Abstract: A linear compressor employing a piezoelectric actuator operating in resonance at a frequency substantially below its natural resonant frequency, which is usually of the order of 10 kHz. Low frequency resonance operation of the actuator, of the order of 100 Hz., is achieved by incorporating the actuator and its housing with the moving compression piston, such that the moving mass is substantially increased, and by reduction of the effective piezoelectric stiffness using hydraulic amplification of the actuator displacement. Both these procedures result in a reduction of the actuator resonant frequency. The hydraulic amplification is achieved by using a hydraulic chamber with different sized pistons, linking the actuator motion with motion of the actuator housing, to which the compressor piston is attached. The high efficiency achieved and the lack of moving parts or the need for lubricating oil makes the compressor ideal for use in high reliability and high purity applications.

Abstract: A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.

Abstract: Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of SEQ ID NO:15 and 2) each of SEQ ID NOs:16 and 17, but does not comprise the contiguous amino acids of SEQ ID NOs:8, 9, 11, or 12. Also disclosed are nucleic acids encoding the variant RTEF-1 polypeptides of the present invention. Pharmaceutical compositions that include the polypeptides and nucleic acids of the present invention are also disclosed. Methods of inducing cell contact inhibition, regulating organ size, and reducing intracellular YAP activity are also set forth, as well as methods of treating hyperproliferative diseases such as cancer using the pharmaceutical compositions of the present invention.