Patents Assigned to DEVELOPMENT FOUNDATION
  • Example-based audio inpainting
    Patent number: 9583111
    Abstract: A method for packet loss concealment, that includes: continuously receiving a digital audio stream; extracting audio features from the digital audio stream while the digital audio stream is unharmed; and upon detecting a gap in the digital audio stream, filling the gap with one or more previous segments of the digital audio stream, wherein the filling is based on a matching of the one or more of the extracted audio features with one or more audio features adjacent to the gap.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: February 28, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Yoav Schechner, Michael Elad, Yuval Bahat
  • ENCAPSULATED MESENCHYMAL STEM CELLS AND USES THEREOF
    Publication number: 20170049821
    Abstract: Provided is a composition-of-matter comprising a microcapsule encapsulating mesenchymal stem cells, wherein at least 97% of cells in said microcapsule are said mesenchymal stem cells. Also provided are methods of generating and using the composition-of-matter.
    Type: Application
    Filed: September 4, 2016
    Publication date: February 23, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Marcelle MACHLUF, Amit GOREN
  • Method of treatment of disease
    Patent number: 9572816
    Abstract: An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: February 21, 2017
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Zeev Gross, Adi Haber, Itzchak Angel
  • Manufacturing and applications of adhesive materials
    Patent number: 9572908
    Abstract: A novel method of manufacturing and applications of a composition of matter comprising of a cross-linked form of a polysaccharide, at least one cross-linking agent comprised of divalent ions for effecting said cross-linked form of said polysaccharide, and at least one synthetically prepared phloroglucinol compound selected from the group comprising of phloroglucinol, a derivative of phloroglucinol, and a polymer synthetically prepared from phloroglucinol or a derivative of phloroglucinol, as an adhesive in procedures for reattaching or repairing body parts or components thereof, such as tissue, of (human or animal) subjects, especially under wet conditions, for example, involving adhesion of wet surfaces.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: February 21, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Havazelet Bianco-Peled, Ronit Biton
  • Example-based cross-modal denoising
    Patent number: 9576587
    Abstract: A method for cross-modal signal denoising, the method comprising using at least one hardware processor for: providing a first multi-modal signal comprising at least two relatively clear modalities; correlating features exhibited simultaneously in the at least two relatively clear modalities of the first multi-modal signal; providing a second multi-modal signal comprising at least one relatively noisy modality and at least one relatively clear modality; and denoising the at least one relatively noisy modality of the second multi-modal signal by associating between (a) features exhibited in the at least one relatively noisy modality of the second multi-modal signal and (b) the features of the first multi-modal signal.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 21, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Dana Segev, Yoav Schechner, Michael Elad
  • Methods of generating corneal cells and cell populations comprising same
    Patent number: 9574171
    Abstract: A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: February 21, 2017
    Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Joseph Itskovitz-Eldor, Daniel Aberdam, Ruby Shalom-Feuerstein
  • Urocortin 2 analogs and uses thereof
    Patent number: 9572866
    Abstract: Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: February 21, 2017
    Assignee: Research Development Foundation
    Inventors: Wylie W. Vale, Jr., Joan M. Vaughan, Cindy Donaldson, Wolfgang Fischer, Jean E. F. Rivier
  • Sensing device having a thermal antenna and a method for sensing electromagnetic radiation
    Patent number: 9568367
    Abstract: A method and a sensing device are provided. The sensing device may include: a thermal antenna that includes a resistive material and has a cross section that has dimensions that are of an order of a micron or of a sub-micron. The thermal antenna may receive electromagnetic radiation and directly convert it to heat. The sensing device may also include a supporting element, a thermal sensor arranged to generate detection signals responsive to a temperature of a sensed area of the thermal sensor, a holding element that may support and thermally isolate the thermal antenna and the thermal sensor and thermally isolate, and a readout circuit that may process the detection signals to provide information about the electromagnetic radiation that is directly converted to heat by the thermal antenna. The thermal antenna and the thermal sensor are spatially separated from the supporting element.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: February 14, 2017
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Yael Nemirovsky, Dan Corcos, Shlomo Katz, Alexander Svetlitza, Madlena Dolgin
  • STY PEPTIDES FOR INHIBITION OF ANGIOGENESIS
    Publication number: 20170037091
    Abstract: Peptides for the treatment of cancer and angiogenic disorders are provided. In some aspects, the peptides may be used to decrease angiogenesis or VEGF expression or function in a cancer such as, e.g., an ocular cancer. In some embodiments, a peptide of the present invention may be used to treat an angiogenic eye disorder such as, e.g., diabetic retinopathy.
    Type: Application
    Filed: February 25, 2015
    Publication date: February 9, 2017
    Applicant: Research Development Foundation
    Inventors: Tim STOUT, Bissan AHMED, Binoy APPUKUTTAN, Trevor J. McFARLAND
  • Physico-chemical process for removal of nitrogen species from recirculated aquaculture systems
    Patent number: 9560839
    Abstract: The present invention provides processes for removing nitrogen species from fresh water or high salinity water recirculated aquaculture systems. The processes are based on physico-chemical treatments which are performed at ambient temperatures and at low p H values thus keeping the total ammonia nitrogen concentrations below a value which is considered detrimental for the growth or survival rate of cultured fish/shrimp.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: February 7, 2017
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Ori Lahav, Youri Gendel, Noam Mozes, Ayana Benet Perlberg, Yuri Hanin
  • System and method for energy conversion by pressure wave and/or phase-exchange
    Patent number: 9562522
    Abstract: System and method for converting energy; the system comprising: an acoustic resonator; a phase-exchange device configured for forming across a section of said resonator a concentration gradient of a first substance in a gaseous medium contained by said resonator, to thereby generate a pressure wave within said resonator; and a conversion device for converting mechanical energy constituted by said pressure wave to non-mechanical energy.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 7, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yehuda Agnon, Guy Ramon, Carlos Dosoretz
  • CONTROL OF INTERACTIONS WITHIN VIRTUAL ENVIRONMENTS
    Publication number: 20170028302
    Abstract: A method for restricting the number of consequential interactions to further virtual objects having a relationship with a first virtual object, resulting from an interaction with said first virtual object. The method comprises: defining a maximum number of consequential interactions, counting consequential interactions, and stopping further interaction when the maximum number of consequential interactions is reached.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Gershon ELBER, Orit SHAKED, Oded SHMUELI
  • Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling
    Patent number: 9555032
    Abstract: Methods for treating or preventing tauopathies and/or A? amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimer's disease by administration of CRF-R1 selective antagonist are provided.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: January 31, 2017
    Assignee: Research Development Foundation
    Inventors: Robert A. Rissman, Kuo-Fen Lee, Wylie W. Vale, Paul E. Sawchenko
  • Clock and data recovery circuit with bidirectional frequency detection and electronic device using the same
    Patent number: 9559705
    Abstract: A clock and data recovery (CDR) circuit is provided. A phase detection circuit receives an input signal and a clock signal to output a first voltage signal. A first comparing circuit determines whether the first voltage signal is within a voltage range to output a first up signal and a first down signal. A counting circuit updates a counting value according to the input signal and the clock signal. A second comparing circuit determines whether the counting value is within a value range to output a second up signal and a second down signal. A selection circuit outputs a second voltage signal according to the first up signal, the first down signal, the second up signal, and the second down signal. A voltage controlled oscillator outputs the clock signal according to the first voltage signal and the second voltage signal.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: January 31, 2017
    Assignees: NCKU RESEARCH AND DEVELOPMENT FOUNDATION, HIMAX TECHNOLOGIES LIMITED
    Inventors: Soon-Jyh Chang, Yen-Long Lee, Chung-Ming Huang, Yen-Chi Chen
  • Robotic mechanism with two degrees of freedom
    Patent number: 9550299
    Abstract: A robotic link mechanism comprising a pair of base elements connected by a passive flexible joint, such that flexure of the joint changes the mutual orientation of the base elements. A pair of obliquely truncated cylinders are confined between the base elements such that the obliquely formed end surfaces of the cylinders can rotate in sliding contact with each other, and the other end of each cylinder can rotate in sliding contact with its associated base element. Driving motors are attached to the base elements, each one controlled to rotate the cylinder associated with that base element, such that rotation of at least one of the cylinders causes the base elements to undergo change in their mutual orientation. The mechanism thus has a backbone composed of the passive flexible joint, which is supported and actuated by the oblique truncated cylindrical structure that serves as an active exoskeleton.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: January 24, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Alon Wolf, Oded Salomon
  • Volatile organic compounds as diagnostic markers for various types of cancer
    Patent number: 9551712
    Abstract: The present invention provides sets of VOCs for breath analysis. Methods of use thereof in diagnosing, monitoring or prognosing breast cancer, head and neck cancer, prostate cancer or colon cancer are disclosed.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: January 24, 2017
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Hossam Haick, Meggie Hakim
  • Cripto antagonism of activin and TGF-b signaling
    Patent number: 9546210
    Abstract: Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: January 17, 2017
    Assignee: Research Development Foundation
    Inventors: Wylie Vale, Craig A. Harrison, Peter C. Gray
  • Method for engineering proteases and protein kinases
    Patent number: 9546359
    Abstract: Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects, TEV proteases with altered substrate specificity, potency, and/or efficiency are provided.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 17, 2017
    Assignee: Research Development Foundation
    Inventors: Brent Iverson, George Georgiou, Joseph M. Taft, Li Yi
  • Memristive akers logic array
    Patent number: 9548741
    Abstract: A device that includes a memristive Akers logic array, wherein the memristive Akers logic array comprises multiple primitive logic cells that are coupled to each other; wherein each primitive logic cell comprises at least one memristive device.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: January 17, 2017
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Shahar Kvatinsky, Avinoam Kolodny, Yifat Hanein
  • Method and system for transmitting light
    Patent number: 9544065
    Abstract: A method of transmitting light is disclosed. The method comprises: transmitting a first light pulse into a medium to form in the medium a filamented region that is capable of guiding light, and transmitting a second light into the filamented region, wherein the second light is a pulsed light or continues wave light, and wherein the second light is transmitted at least 10 nanoseconds after the first light pulse.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 10, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Mordechai Segev, Oren Cohen, Liad Levi