Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.

Abstract: An apparatus for pad printing includes a printing pad (12). A textured transfer member (13) is configured to be pressed alternately by the printing pad (12) against an ink carrier (17) and against a substrate (24) so as to transfer an ink pattern to the substrate.

Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.

Abstract: The present disclosure provides a delivery system comprising (i) a physiologically acceptable carrier and (ii) a proteolytic enzyme or effector thereof for use in a method for relaxing fibers within a subject's oral cavity. In some embodiments, the relaxation is for use in tooth manipulation (particularly repositioning). In some embodiments, the method involves the use of the proteolytic enzyme or effector thereof at a concentration effective to cause relaxation of fibers between the tooth's alveolar bone and gingiva while maintaining integrity of the fibers surrounding the tooth. Also disclosed herein are methods for fiber relaxation and/or repositioning of tooth making use of the proteolytic enzyme or effector thereof.

Abstract: Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, are disclosed. Also disclosed are pharmaceutical compositions containing the same, and uses thereof in the treatment of medical conditions associated with a pathogenic microorganism.

Abstract: An electron beam shaping unit for use in electron beam column and a method for designing thereof is presented. The electron beam shaping unit is configured for affecting electron beams of high density or strong electron-electron repulsion. These 5 beams can always be modeled with multi electron wave function. The electron beam shaping unit comprises a mask unit configured for affecting propagation of electrons therethrough to thereby form a propagating electron beam having, at far field, radial shape as determined by multi-electron non-linear function being an eigen function determined by a multi-electron Hartree-Fock Hamiltonian.

Abstract: A sensor technology comprising a single nano-material (gold nanoparticles and/or carbon nanotube) based sensor or a plurality of sensors in conjunction with a pattern recognition algorithm for non-invasive and accurate diagnosis of tuberculosis caused by M. tuberculosis bacteria in a subject. The sensor technology is suitable for population screening of tuberculosis, particularly in resource-poor and developing countries.

Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Abstract: A system for converting an input oscillation having an input frequency into an output oscillation having an output frequency is disclosed. The system comprises: a controller configured for receiving the input oscillation and responsively generating a multi-component drive signal. A frequency of at least one component of the drive signal is other than two times the input frequency. In some embodiments, a frequency of another component of the drive signal equals about two times the output frequency. The system also comprises an oscillator for generating pump oscillations responsively to the drive signal and applying parametric excitation to the input oscillation at the pump oscillations.

Abstract: A method that uses at least one hardware processor for receiving a three-dimensional model of an object, receiving an audio sequence embodied as a digital file that comprises a musical composition, generating a video frame sequence, and synthesizing the audio sequence and the video frame sequence into an audiovisual clip. The three-dimensional model is embodied as a digital file that comprises a representation of the object. The generating step comprises computing a caricature of the object by applying a computerized caricaturization algorithm to the three-dimensional model. The computing has scaling gradient fields of surface coordinates of the three-dimensional model by a function of a Gaussian curvature of the surface, and finding a regular surface whose gradient fields fit the scaled gradient fields.

Abstract: The present invention is directed to methods and kits useful for diagnosis and/or prognosis of urothelial cancer in a subject. The present invention further relates to methods of assessing severity of cancer and methods of determining efficacy of a treatment for cancer. The methods and kits of the invention comprise determining the levels of semaphorin 3A in a biological sample of a subject.

Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliary Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.

Abstract: A specified proton concentration in a volume (80) is produced by passing a controlled electrophoresis current through an adjacent electrophoresis volume (28) between a working electrode (26) and a counter electrode (24). An array of such volumes with specified proton concentration is used to provide the pH gradient for isoelectric focusing.

Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.

Abstract: A multifunctional dielectric gradient metasurface optical device has a layer of nanoscale dielectric gradient metasurface optical antenna elements deposited on a substrate layer, arranged with spatially varying orientations, shapes, or sizes in the plane of the device such that the optical device has a spatially varying optical phase response capable of optical wavefront shaping. The spatially varying optical phase response is a spatial interleaving of multiple distinct phase profiles corresponding to multiple optical sub-elements, thereby providing multifunctional wavefront shaping in the single optical element.

Abstract: A method of creating a real time synthetic model tracking a dynamic physical entity, comprising: a) Receiving multiple points extracted from a sequence of 3D information depicting a dynamic physical entity, each point is associated with position and photometric information. b) Identifying, within the multiply of points, a cloud point which includes multiple entity representative points which portray a surface of the dynamic physical entity. c) Generating a points-surface for a synthetic model by creating spatial presentation of the entity representative points through calculation of principal curvatures for each entity representative point according to the respective position information. d) Generating a continuous surface for the synthetic model by texturing ellipsoidal shapes created for each entity representative point according to the respective photometric information.

Abstract: An orthogonal frequency division multiplexing (OFDM) transmitter that includes an encoder, an interleaver, a symbol processor; and a transmission module; wherein the encoder is configured to encode a superframe to provide an encoded superframe; wherein the encoded superframe comprises a sequence of encoded frames; wherein the interleaver is configured to allocate multiple frequency sub-bands to each encoded frame of the encoded superframe by assigning adjacent frequency sub-bands to successive symbols of each encoded frame; wherein the symbol processor is configured to generate, for each encoded frame and according to the assignment of the multiple frequency sub-bands, an intermediate set of symbols; and wherein the transmission module is configured to transmit simultaneously, for each encoded frame, OFDM symbols that represents the intermediate set of symbols.

Abstract: Provided are nucleic acid constructs which comprise a polynucleotide encoding adenosine phosphate-isopentenyltransferase (IPT) operably linked to a stress-related promoter. Also provided are host cells transformed with the nucleic acid constructs, transgenic plants expressing the IPT coding sequence under the transcriptional regulation of a stress-related promoter and methods of using same for increasing abiotic stress tolerance of a plant, and biomass of plants under stress or normal conditions.

Abstract: A system for generating a mechanical wave is disclosed. The system comprises a camshaft having plurality of rotatable cams, serially mounted on a shaft along an axis of an elastic tubular shell to form a varying phase angle along the shaft. The system further comprises a plurality of cam followers arranged circumferentially about each cam, such that a rotary motion of the cams generates a linear motion of the cam followers to radially bias in internal wall the shell. The variation of the phase angle is selected to generate a three-dimensional traveling wave along the shell.

Abstract: A low order filter circuit having a frequency correction function, a frequency correction method for a low order filter circuit, and a high order filter circuit are provided. An analog to digital converter (ADC) may detect a peak of a signal processed by a second order filter unit, and after comparison and determination are performed by a digital correction unit, a frequency control signal is outputted as a feedback to a notch filter or a band-pass filter in the second order filter unit where frequency adjustment is performed. The high order filter circuit is integrated by a plurality of the low order filter circuits. Before correcting the high order filter circuit, switch units may restore the high order filter circuit to the low order filter circuits for correction, and then combine the corrected low order filter circuits to form the original high order filter circuit.