Abstract: The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical compositions thereof.

Abstract: A method for managing communication among a plurality of social network members. The method comprises defining a multi participant task, setting at least one forward rule limiting the distribution an invitation message for participating in the multi participant task, forwarding the invitation message to at least one addressee from a plurality of social network members, allowing the at least one addressee to forward the invitation message to at least one additional addressee from the plurality of social network members under the at least one forward rule, monitoring a plurality of feedbacks to the invitation message to determine whether the multi participant task is achieved, and updating a status of the multi participant task according to the determination.

Abstract: A self cleaning inlet head for use on a shunt. The head has a tube with openings disposed in predetermined positions in its wall, and a cleaning element installed inside the tube. The cleaning element may comprise a central shaft with a number of bristles protruding therefrom, preferably in locations substantially identical to the positions of the openings in the wall of the tube. Mutual vibratory motion between the cleaning element and the tube causes at least some of the bristles to enter the openings, thereby keeping them clear, and preventing tissue growth into them. The vibratory motion may be generated by the action of an external field on a responsive part of the cleaning element, such as an external magnetic field operating on a magnetic or magnetized part of the cleaning element or the bristles. Alternatively, the external field may be an ultrasound field operating on the bristles.

Abstract: Recombinant gelonin polypeptides with decreased antigenicity are provided. Cell-targeted constructs comprising said recombinant gelonin polypeptides are also provided. Such constructs can be used in methods for targeted cell killing, such as for treatment of cell proliferative diseases (e.g., cancer).

Abstract: A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2? or ?. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

Abstract: A method of generating light is disclosed. The method comprises: directing an optical pulse to a semiconductor optical amplifier being at a temperature above 0° C. The optical pulse is preferably characterized by a wavelength within an emission spectrum of the semiconductor optical amplifier and by a pulse area selected to induce Rabi oscillations in the semiconductor optical amplifier, and to emit light at a frequency of at least 1 THz.

Abstract: A specified proton concentration in a volume (80) is produced by passing a controlled electrophoresis current through an adjacent electrophoresis volume (28) between a working electrode (26) and a counter electrode (24). An array of such volumes with specified proton concentration is used to provide the pH gradient for isoelectric focusing.

Abstract: An auto-contrast enhancement system includes a human visual system (HVS)-based local difference (LD) histogram unit configured to build a LD histogram with respect to intensity values; a histogram classifier configured to categorize histograms of input images based on distribution properties; and a histogram equalization (HE) unit configured to process the input image according to a result of the HVS-based LD histogram unit and the enhancement level determined in the histogram classifier.

Abstract: An inflatable connector comprising a bladder having at least two pipe securing areas formed as at least two separate cylindrical voids, respectively, in said bladder, wherein said at least two separate cylindrical voids are completely separated by a portion of said bladder and are configured to at least partially encompass at least two pipe portions, respectively, wherein said bladder is configured, when deflated, to enable insertion of said at least two pipe portions into said at least two pipe securing areas, respectively, and wherein said bladder is configured, when inflated, to secure said at least two pipe portions in said at least two pipe securing areas, respectively.

Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Abstract: A process for producing hydrogen from natural gas, said process comprises the steps of: (i) providing an autothermal heat exchanger packed-bed membrane reformer (APBMR) comprising: (a) an elongated external gas oxidation compartment comprising an inlet, an outlet and packed oxidation catalyst particles, said inlet and outlet being located each at one extremity of said external gas oxidation compartment; (b) an elongated internal gas steam-reforming compartment comprising an inlet, an outlet and packed steam-reforming catalyst particles, said inlet and outlet being located each at one extremity of said internal gas steam-reforming compartment; (c) one or more hydrogen-separating membrane(s) positioned in said steam-reforming compartment substantially parallel to the longitudinal axis of said steam-reforming compartment; (d) one insulation layer surrounding said external compartment; and, optionally, (e) one or more elongated internal gas oxidation compartment(s) positioned in said steam-reforming compartment s

Abstract: The present invention provides a system and method for diagnosing, monitoring, prognosing or staging Parkinson's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof or metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Abstract: Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination.

Abstract: A method and computing program for providing a user computing platform with a response to a query, the response comprising indications to one or more Universal Resource Identifier optionally with instructions on how to get the relevant information from there, and how to format the response. Thus a user computing platform receives information directly from a content provider, whose rights are not infringed by the query engine. If payment or other limitations are imposed by the content provider or by the user, they are handled between the user and the content provider, without intervention by the query engine.

Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or tissues. Further, promoters are providing that are amenable to control by activators, enhancers, or repressors. These vectors are in a self-inactivating configuration for biosaftey. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element, without any decrease in the specificity or control exerted by the promoters.

Abstract: Polymeric foams and elastomer/hydrogel bicontinuous composite structures derived from high internal phase emulsions and possessing shape-memory characteristics are disclosed, as well as processes for forming the same and uses thereof in, for example, manufacturing of various articles.

Abstract: A clock and data recovery circuit and a method for estimating jitter tolerance thereof are provided. A first phase signal is generated by a phase detector, and a second phase signal is used to generate a clock signal. The second phase signal is set to be identical to the first phase signal during an operation mode. A counting is started and the first phase signal is inversed to generate the second phase signal during a test mode. Whether a data signal has an error is determined. The counting is stopped to generate a count value when determining that the data signal has the error during the test mode. A tracing speed is computed according to the count value and a predetermined unit interval.

Abstract: A method training a randomized decision tree through multiple iterations, each is based on: a) Receiving multiple data samples that include data subsets, each data subset corresponds to an attribute. b) Distributing the data subsets to slave processing units after sorting the data samples in consecutive ascending order by updating a first index that identifies trajectories of the training data samples through the tree nodes of the previous tree level. c) Simultaneously processing the data subsets to identify split functions for each tree node with respect to each data subset and updating a second index that identifies the trajectories of the training data samples through the tree node of the current tree level. d) Collecting the split functions from the slave processing units and constructing the current tree level by selecting a preferred split function for each tree node of the current tree level.

Abstract: Methods and compositions are provided for stimulating insulin production, increasing beta cell mass, or decreasing beta cell loss in a subject. For example, methods of the embodiments can comprise administration of a corticotropin-releasing factor (CRF)1 receptor agonist and a CRF2 receptor agonist. Also provided are pharmaceutical compositions comprising a selective CRF1 receptor agonist and a selective CRF2 receptor agonist.

Abstract: The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.