Abstract: An electronic device includes at least one photodetection block, where the at least one photodetection block includes a plurality of macropixels arranged into an array. Each macropixel includes an array of photodiodes, with logic circuitry coupled to outputs of the array of photodiodes and configured to generate a detection signal as a function of logically combining the outputs of the array of photodiodes. Each macropixel has associated therewith selection circuitry configured to selectively pass the detection signal to output combining logic or to output combining logic of at least one neighboring macropixel of the plurality thereof. The output combining logic has inputs coupled to the selection circuitry and to the selection circuitry of the at least one neighboring macropixel, and is configured to generate an output detection signal as a function of logically combining outputs of the selection circuitry and the selection circuitry of the at least one neighboring macropixel.

Abstract: The present invention relates to a method of detecting nucleic acid in a sample comprising a flocculant and a recombinant protein, the method comprising (a) adding heparin and a detergent to the sample, (b) amplifying at least a portion of the nucleic acid, and (c) detecting the amplification in step (b), thereby detecting the nucleic acid in the sample. The present invention also relates to a method of detecting nucleic acid in a sample comprising a flocculant and a recombinant protein, the method comprising (a) adding a detergent and sodium hydroxide to the sample, (b) amplifying at least a portion of the nucleic acid, and (c) detecting the amplification in step (b), thereby detecting the nucleic acid in the sample.

Abstract: An optical sensor includes pixels. Each pixel has a photodetector and a semiconductor guard ring around the photodetector. The photodetector and the semiconductor guard ring are dimensioned so that a fill factor of the pixel is less than or equal to 50%.

Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A pixel includes a single photon avalanche diode (SPAD) having a cathode coupled to a high voltage supply through a quenching element, with the SPAD having a capacitance at its anode formed from a deep trench isolation, with the quenching element having a sufficiently high resistance such that the capacitance is not fully charged when the SPAD is struck by an incoming photon. The pixel includes a clamp transistor configured to be controlled by a voltage clamp control signal to clamp voltage at an anode of the SPAD when the SPAD is struck by an incoming photon to be no more than a threshold clamped anode voltage, and readout circuitry coupled to receive the clamped anode voltage from the clamp transistor and to generate a pixel output therefrom. The threshold clamped anode voltage is below a maximum operating voltage rating of transistors forming the readout circuitry.

Abstract: A photodetection circuit includes a single photon avalanche diode (SPAD), and an active quenching circuit coupling the SPAD to an intermediate node and having a variable RC constant. The variable RC constant provides a first RC constant during an idle state so that when the SPAD detects a photon, the SPAD avalanches to begin quenching to set a magnitude of a voltage at a terminal of the SPAD to a quench voltage, the quench voltage being greater than a threshold voltage; a second RC constant greater than the first RC constant during a hold off period during which the quenching occurs so as to maintain the voltage at the terminal of the SPAD at a magnitude that is above the threshold voltage during the hold off period; and a third RC constant less than the second RC constant but greater than the first RC constant during a recharge period during which the SPAD is recharged.

Abstract: A photodetection circuit includes a single photon avalanche diode (SPAD) having a cathode coupled to a high voltage supply through a quench resistance and an anode coupled to a first node, a capacitive deep trench isolation capacitor coupled between the first node and ground, and a first n-channel transistor. The first n-channel transistor has a drain coupled to the first node, a source coupled to ground, and a gate coupled to a resistance control signal. A second n-channel transistor has a drain coupled to the first node, a source coupled to ground, and a gate coupled to a second node. An inverter has an input coupled to the first node and an output coupled to an intermediate node. A current starved inverter has an input coupled to the intermediate node and an output coupled to the second node.

Abstract: An electronic integrated circuit chip includes a semiconductor substrate with a front side and a back side. A first reflective shield is positioned adjacent the front side of the semiconductor substrate and a second reflective shield is positioned adjacent the back side of the semiconductor substrate. Photons are emitted by a photon source to pass through the semiconductor substrate and bounce off the first and second reflective shields to reach a photon detector at the front side of the semiconductor substrate. The detected photons are processed in order to determine whether to issue an alert indicating the existence of an attack on the electronic integrated circuit chip.

Abstract: Various embodiments provide a control circuit that includes at least one active module designed to enable an avalanche diode. The control circuit also includes at least one passive module designed to disable the avalanche diode.

Abstract: A device receives location information and work order information associated with multiple vehicles, and groups the location information into engine off information, idling information, and journey information. The device combines, based on the journey information, the engine off information and the idling information to generate vehicle stop information associated with the plurality of vehicles, and matches corresponding work order information with the vehicle stop information to generate matched information. The device extracts stop-wise features, points of interest features, stop cluster features, and sequential features from the vehicle stop information, and utilizes the stop-wise features, the points of interest features, the stop cluster features, and the sequential features with a model to determine work order stops and non-work order stops for the multiple vehicles. The device provides information associated with the work order stops and the non-work order stops for the multiple vehicles.

Abstract: A transmit integrated circuit includes a light source configured to generate a beam of light. A receive integrated circuit includes a first photosensor. A transmit optic is mounted over the transmit and receive integrated circuits. The transmit optic is formed by a prismatic light guide and is configured to receive the beam of light. An annular body region of the transmit optic surrounds a central opening which is aligned with the first photosensor. The annular body region includes a first reflective surface defining the central opening and further includes a ring-shaped light output surface surrounding the central opening. Light is output from the ring-shaped light output surface in response to light which propagates within the prismatic light guide in response to the received beam of light and which reflects off the first reflective surface.

Abstract: A time-of-flight ranging system disclosed herein includes a receiver asserting a photon received signal in response to detection of light that has reflected off a target and returned to the time-of-flight ranging system. A first latch circuit has first and second data inputs receiving a first pair of differential timing references, the first latch circuit latching data values at its first and second data inputs to first and second data outputs based upon assertion of the photon received signal. A first counter counts latching events of the first latch circuit during which the first data output is asserted, and a second counter counts latching events of the first latch circuit during which the second data output is asserted. Processing circuitry determines distance to the target based upon counted latching events output from the first and second counters.

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

Abstract: The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The present disclosure relates to an avalanche diode including at least one PN junction; at least one depletion structure located adjacent to the PN junction and configured to form a depletion region; and at least two electrodes to polarize the at least one PN junction.

Abstract: The present disclosure relates to a device that includes a photodiode having a first terminal that is coupled by a resistor to a first rail configured to receive a high supply potential and a second terminal that is coupled by a switch to a second rail configured to receive a reference potential. A read circuit is configured to provide a pulse when the photodiode enters into avalanche, and a control circuit is configured to control an opening of the switch in response to a beginning of the pulse and to control a closing of the switch in response to an end of the pulse.

Abstract: A new distinct variety of grapevine named ‘ARRATHIRTYTHREE’ abundantly forms attractive crisp seedless berries with a creamy yellow-green skin coloration; lax small-medium clusters which display a light muscat flavor. The fruit commonly is ready for harvesting during the end of June in San Joaquin Valley of Central California, U.S.A., and displays good eating qualities as a table grape. The fruit firmness renders the fruit well amenable for handling, shipping, and storage.