Abstract: A method and system for identifying recurrent stops of a vehicle fleet having a plurality of vehicles. The method comprises retrieving historical GPS tracks of the vehicle fleet over a period of time; detecting stops made by the vehicle fleet along travelled routes that are associated with the historical GPS tracks; constructing a coverage area that covers the travelled routes; discretizing the coverage area into a plurality of cells; determining whether a cell is a recurrent stop based on a fleet stay period associated with that cell; and classifying a determined recurrent stop into a plurality of categories.

Abstract: An imaging sensor includes a pixel array containing photodiodes, the photodiodes being isolated from one another by full thickness deep trench isolations. Row control circuitry controls which rows of the pixel array operate in an imaging mode and which rows of the pixel array operate in an energy harvesting mode, on a row by row basis. Switch circuitry selectively connects different groups of photodiodes in rows operating in the energy harvesting mode into forward biased series configurations between a voltage output line and a ground line, or into forward biased parallel configurations between the voltage output line and the ground line.

Abstract: A device may obtain video data associated with a driving event involving a first vehicle. The device may determine a vanishing point associated with the video data and may construct a cone of impact of the first vehicle based on the vanishing point. The device may detect a second vehicle within the cone of impact and may analyze the subset of video frames to determine a distance between the first vehicle and the second vehicle. The device may determine a speed of the first vehicle during a time period associated with a subset of video frames. The device may determine a headway score, representative of a severity associated with the first vehicle being within a proximity threshold of the second vehicle during the time period, based on the distance and the speed. The device may determine an occurrence of a tailgating event based on the headway score.

Abstract: A photonic device includes a PCB having an integrated circuit mounted thereon, with a cap mounted to the PCB and carrying a lens positioned over the integrated circuit. The cap is formed by: an outer wall mounted to the PCB, extending upwardly from the PCB, and surrounding a portion of the integrated circuit; a first retention structure extending inwardly from the outer wall and across the integrated circuit, the first retention structure having a hole defined therein; and a second retention structure having a hole defined therein, the second retention structure being affixed within the first retention structure such that the hole in the second retention structure is axially aligned with the hole in the first retention structure. The lens is mechanically constrained within the cap between the first retention structure and the second retention structure.

Abstract: The invention relates to compounds of Formula (I), salts thereof, combinations, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

Abstract: A method for modulating a signal including operating a circuit in a first arrangement during a first operating interval and switching the circuit between the first arrangement and a second arrangement during a first modulation interval to vary a load on the circuit to produce a first amplitude shift keying (ASK) signal. The method further includes detecting a voltage on the circuit crossing a threshold level and operating the circuit in the second arrangement during a second operating interval. The method also includes switching the circuit between the second arrangement and the first arrangement during a second modulation interval to vary the load on the circuit to produce a second ASK signal.

Abstract: A computer-implemented method of tracking vessel movement which comprises receiving a first vessel data message comprising a first vessel identifier, the first vessel data message having been transmitted at a first time and being associated with a first position; and receiving a second vessel data message comprising a second vessel identifier, the second vessel data message having been transmitted at a second time and being associated with a second position. The method also comprises determining if the first vessel identifier and the second vessel identifier are related. If the first vessel identifier and the second vessel identifier are related, a speed required for a vessel to have moved from the first position to the second position is determined; which is then determined if the speed is below a speed threshold; and if the speed is below the speed threshold, the first position is associated with the second position.

Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.

Abstract: The present disclosure relates to compositions for treating CD96 mediated diseases, and related methods.

Abstract: A device may receive, from a first vehicle, video data for video captured of a location associated with an accident for a second vehicle, and may process the video data, with a first model, to generate a sparse point cloud of the location associated with the accident. The device may process the video data, with a second model, to generate depth maps for frames of the video data, and may utilize the depth maps with the sparse point cloud to generate a dense point cloud. The device may process the video data, with a third model, to generate a dense semantic point cloud, and may process the dense semantic point cloud, with a fourth model, to determine a dense semantic overhead view of the location associated with the accident. The device may perform actions based on the dense semantic overhead view.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding compositions, and methods and/or uses in therapy, for example in the treatment of parasitic infections such as malaria, in particular infection by Plasmodium falciparum.

Abstract: Provided are methods for inhibiting binding of systemically administered drugs to a target in the skin by topically administering materials prior to or concomitantly with administration of the systemic drugs.

Abstract: A maneuver classification platform may obtain video data and telematic data that are associated with a driving event involving a vehicle. The maneuver classification platform may analyze the video data to identify a path of the vehicle along a roadway during the driving event, and based on markings of a plurality of roadways. The maneuver classification platform may analyze the video data to determine a type of a vehicle maneuver performed by the vehicle during the driving event. The maneuver classification platform may determine a maneuver score of the driving event based on the type of the vehicle maneuver, the path of the vehicle, and the telematic data. The maneuver classification platform may send a message associated with the maneuver score and a vehicle identifier of the vehicle to a client device to permit the client device to use the maneuver score.

Abstract: A modular production system including a plurality of production modules connected in a linear series to form a production tunnel, and collectively defining a production channel, and wherein at least one fluid inlet port defined along the production tunnel, said inlet port is in fluid communication with a pressurized fluid source, whereby influx of fluid from said fluid source through said fluid inlet port acts to maintain the fluid pressure within the production channel at a higher pressure than the atmospheric pressure outside of the production tunnel; and wherein one of said production modules positioned between said proximal-most and distal-most production modules comprises a depyrogenator and/or sterilization module, comprising a transparent tubular body, and an irradiation source positioned external to said transparent tubular body, said irradiation source capable of heating the internal environment of the depyrogenation and/or sterilization module to a temperature sufficient to depyrogenate or sterilize

Abstract: A lens is positioned to be received by a lens holder. The lens includes a first electrical trace and the lens holder includes a second electrical trace. The first and second electrical traces form electrodes of a sense capacitor. A capacitance of the sense capacitor is sensed. From the sensed capacitance, a determination is made as to whether the lens is present and properly positioned in the lens holder.