Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract: Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: An apparatus includes at least one detector configured to receive return light from an object within a detector field of view the light generated by a light source. The detector includes first and second photosensitive regions configured to receive the return light from the light source. At least one non-photosensitive region is included, and the first and second photosensitive regions are separated by the at least one non-photosensitive region. The at least one non-photosensitive region is associated with one of the first or second photosensitive regions.

Abstract: The invention relates to compounds of Formula (I), (II), (III) or (IV), salts thereof, pharmaceutical compositions thereof, as well as methods of treating, curing or preventing HIV in subjects.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A hybrid analog-digital pixel circuit is fabricated on two wafers. A first wafer includes the analog pixel circuitry and a second wafer includes the digital control and processing circuitry. Externally accessible contact structures for electrically interconnecting the two wafers are arranged in groups. Each group includes externally accessible contact structures for carrying signals associated solely with operation of a corresponding pixel.

Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.

Abstract: This invention relates to a loading mechanism, including a first roller assembly and second roller assembly, at least one mounting for the first and second roller assemblies, wherein the first roller assembly and second roller assembly each have a longitudinal axis, a drive mechanism configured to rotate the first roller assembly and second roller assembly, so as to move an object, wherein as the weight of the object applies pressure to at least one of the first and second roller assemblies the mounting allows the roller assemblies to move so as to change the angle between the longitudinal axis of the first and second roller assemblies.

Abstract: One or more embodiments are directed to charge pump overload detection circuits which may be employed in imaging devices including one or more SPAD arrays, such as proximity sensors and time of flight sensors. One embodiment is directed to a charge pump overload detection circuit that includes a charge pump, a charge pump supply regulation device, a charge pump voltage regulation feedback loop and a charge pump overload detection comparator. The charge pump supplies an output voltage to a load, and the charge pump supply regulation device supplies a regulated voltage to an input of the charge pump. The charge pump voltage regulation feedback loop includes a feedback voltage generator that generates a feedback voltage based on the charge pump output voltage, and an amplifier that generates and provides a charge pump regulation control signal to the charge pump supply regulation device based on a difference between the feedback voltage and a reference voltage.

Abstract: Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.

Abstract: Described herein is an electronic device that includes a first integrated circuit die having formed therein at least one photodiode and readout circuitry to convert charge generated by the at least one photodiode to a read voltage and to selectively output the read voltage. A second integrated circuit die is in a stacked arrangement with the first integrated circuit die and has formed therein storage circuitry to selectively transfer the read voltage to at least one storage capacitor for storage as a stored voltage and to selectively transfer the stored voltage to an output. The at least one storage capacitor is formed from a capacitive deep trench isolation. There is an interconnect between the first and second integrated circuit dies for coupling the readout circuitry to the storage circuitry.

Abstract: An electronic device includes a first integrated circuit die having formed therein photodiodes and readout circuitry for the photodiodes, with the readout circuitry including output pads exposed on a surface of the first integrated circuit die. A second integrated circuit die has formed therein storage capacitor structures for the photodiodes and digital circuitry for performing image processing on data stored in the storage capacitor structures, with the storage capacitor structures including input pads exposed on a surface of the second integrated circuit die. The first and second integrated circuit die are in a face to face arrangement such that the output pads of the first integrated circuit die face the input pads of the second integrated circuit die. An interconnect couples the output pads of the first integrated circuit die to the input pads of the second integrated circuit die.

Abstract: Disclosed herein is a method of optical pulse emission including three phases. During a first phase, a capacitor is charged from a supply voltage node. During a second phase, a voltage stored on the capacitor is boosted, and then the capacitor is at least partially discharged through a light emitting device. During a third phase, the capacitor is further discharged by bypassing the light emitting device. The third phase may begin prior to an end of the second phase.

Abstract: A penetration testing apparatus for testing the bearing strength of ground, soil layers, base-courses, subbases and subgrades without the need for much manual operation, includes the following components operatively connected together, comprising a frame support (5) which supports an actuating apparatus (7), power supply apparatus (9), movable carriage assembly (13), ground penetrating member (15), carriage drive mechanism 17 and ground stabilizing means (18), operatively connected together to carry out a ground test. The movable carriage assembly (13) movably supports one ground penetrating member (15).

Abstract: A new distinct variety of grapevine named ARRATWELVE abundantly forms attractive meaty and juicy seedless berries with a red skin coloration; in medium-to-large clusters which display a sweet and natural flavor. The fruit commonly is ready for harvesting during August in San Joaquin Valley of Central California, U.S.A, and displays good eating qualities as a table grape. The fruit firmness renders the fruit well amenable for handling, shipping, and storage.