Patents Assigned to Development Limited
  • Naphthyridine derivatives as alpha V beta 6 integrin antagonists for the treatment of E.G. fibrotic diseases
    Patent number: 10513517
    Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: December 24, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Niall Andrew Anderson, Ian Baxter Campbell, Matthew Howard James Campbell-Crawford, Ashley Paul Hancock, Seble Lemma, Simon John Fawcett MacDonald, John Martin Pritchard, Panayiotis Alexandrou Procopiou
  • PROTECTED ELECTRONIC INTEGRATED CIRCUIT CHIP
    Publication number: 20190385957
    Abstract: An electronic integrated circuit chip includes a semiconductor substrate with a front side and a back side. A first reflective shield is positioned adjacent the front side of the semiconductor substrate and a second reflective shield is positioned adjacent the back side of the semiconductor substrate. Photons are emitted by a photon source to pass through the semiconductor substrate and bounce off the first and second reflective shields to reach a photon detector at the front side of the semiconductor substrate. The detected photons are processed in order to determine whether to issue an alert indicating the existence of an attack on the electronic integrated circuit chip.
    Type: Application
    Filed: June 10, 2019
    Publication date: December 19, 2019
    Applicants: STMicroelectronics (Rousset) SAS, STMicroelectronics (Research & Development) Limited
    Inventors: Mathieu LISART, Bruce RAE
  • Ranging apparatus
    Patent number: 10502816
    Abstract: A ranging apparatus includes an array of light sensitive detectors configured to receive light from a light source which has been reflected by an object. The array includes a number of different zones. Readout circuitry including at least one read out channel is configured to read data output from each of the zones. A processor operates to process the data output to determine position information associated with the object.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: December 10, 2019
    Assignees: STMicroelectronics (Research & Development) Limited, STMicroelectronics (Grenoble 2) SAS
    Inventors: Bruce Rae, Pascal Mellot, John Kevin Moore, Graeme Storm
  • SUBSTRATE EMBEDDED TIME OF FLIGHT SENSOR PACKAGING
    Publication number: 20190369246
    Abstract: A method begins with forming a first wiring layer on a substrate, forming a cavity in the substrate, and laminating a bottom side of the substrate so as to cover a bottom side of the cavity. Next, an integrated circuit is placed within the cavity of the substrate, and then a first optically transparent layer is disposed on the top surface of the substrate to cover a top surface of the integrated circuit. The first optically transparent layer has an aperture formed therein exposing at least a portion of the top surface of the integrated circuit. A second wiring layer is disposed on a top surface of the first optically transparent layer in a pattern that does not obstruct light traveling to or from the top surface of the integrated circuit. The integrated circuit is a laser emitting integrated circuit or a reflected light detector.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 5, 2019
    Applicant: STMicroelectronics (Research & Development) Limited
    Inventor: William HALLIDAY
  • Single SPAD array ranging system
    Patent number: 10495736
    Abstract: In one embodiment, an imaging device includes a light-emitting device, a driving circuit, a return single-photon avalanche diode (SPAD) array and readout circuitry. The driving circuit generates a driving signal, and the light-emitting device generates an optical pulse based on the driving signal. The return SPAD array is configured to receive a first portion of the optical pulse that is reflected by an object in an image scene. The readout circuitry receives a signal indicative of the received first portion of the optical pulse, and a signal indicative of the driving signal, and determines a distance between the imaging device and the object based on a difference between a time of receiving the signal indicative of the received first portion of the optical pulse and a time of receiving the signal indicative of the driving signal.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: December 3, 2019
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Caixin Zhuang, John Kevin Moore
  • Naphthyridines as integrin antagonists
    Patent number: 10487080
    Abstract: The invention relates to compounds of Formula (I): wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having ?v?6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an ?v?6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: November 26, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Niall Andrew Anderson, Matthew Howard James Campbell-Crawford, Ashley Paul Hancock, Seble Lemma, John Martin Pritchard, Panayiotis Alexandrou Procopiou, Steven Leslie Sollis
  • Nrf2 regulators
    Patent number: 10485806
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: November 26, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics Limited
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • Compounds
    Patent number: 10479792
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: November 19, 2019
    Assignees: GiaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Stephen Brand, Peter George Dodd, Eun Jung Ko, Maria Marco Martin, Timothy James Miles, Lars Henrik Sandberg, Michael George Thomas, Stephen Thompson
  • Wafer level microstructures for an optical lens
    Patent number: 10473834
    Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: November 12, 2019
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Kevin Channon, James Peter Drummond Downing, Andy Price
  • Chemical compounds
    Patent number: 10457674
    Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 29, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Niall Andrew Anderson, Nicholas Paul Barton, Sebastien Andre Campos, Edward Paul Cannons, Anthony William James Cooper, Kenneth David Down, Kevin James Doyle, Julie Nicole Hamblin, Graham George Adam Inglis, Armelle Le Gall, Vipulkumar Kantibhai Patel, Simon Peace, Andrew Sharpe, Gemma Victoria White
  • Vehicle communications using visible light communications
    Patent number: 10461858
    Abstract: An apparatus has a pixel array arrangement having a number of photosensitive detectors. Processing circuitry is configured to process data captured by at least one pixel of the array to provide image information and detect data on an encoded pulsed light signal. In a specific embodiment, data is captured at a vehicle. Information for the vehicle is determined based on the encoded pulsed light signal.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: October 29, 2019
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Jeffrey M. Raynor, Duncan Hall
  • Cyclic di-nucleotides as modulators of STING
    Patent number: 10450341
    Abstract: A compound of formula (1) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer and as vaccine adjuvants.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: October 22, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Keith Biggadike, Aurelie Cecile Champigny, Diane Mary Coe, Deborah Needham, Daniel Terence Tape
  • Optical pulse emitter
    Patent number: 10454246
    Abstract: An optical pulse emitter includes a light emitting device having a first node coupled to an intermediate node via a first switch. The intermediate node is coupled to a supply voltage node via a second switch. A capacitor is coupled to the intermediate node. The first, second and third switches are controlled by a control circuit. During a first phase, the second switch is actuated to couple the capacitor to the supply voltage node. During a second phase, the second switch is deactuated and the first switch is actuated to at least partially discharge the capacitor through the light emitting device. During a third phase, discharge current from the capacitor bypasses around the light emitting device.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: October 22, 2019
    Assignees: STMicroelectronics (Grenoble 2) SAS, STMicroelectronics (Research & Development) Limited
    Inventors: Nicolas Moeneclaey, Shatabda Saha
  • Transient transfection method for retroviral production
    Patent number: 10450574
    Abstract: The invention relates to bacterial artificial chromosomes (BAC) comprising retroviral nucleic acid sequences encoding: gag and pol proteins, and an env protein or a functional substitute thereof, wherein each of the retroviral nucleic acid sequences are arranged as individual expression constructs within the BAC. The invention also relates to uses and methods of transient transfection using said BAC.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: October 22, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Sabine Johnson, Celeste Pallant, Eirini Vamva, Conrad Vink
  • Naphthyridine derivatives useful as alpha-V-beta-6 integrin antagonists
    Patent number: 10450312
    Abstract: A compound of formula (I) or a salt thereof wherein R1 represents a hydrogen atom, a methyl group or a ethyl group R2 represents a hydrogen atom or a fluorine atom R3 represents a hydrogen atom, a methyl group or an ethyl group.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: October 22, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Niall Andrew Anderson, Brendan John Fallon, John Martin Pritchard
  • ELECTRONIC MODULE INCLUDING AN AMBIENT LIGHT SENSOR STACKED OVER A PROXIMITY SENSOR
    Publication number: 20190316959
    Abstract: An electronic module includes an ambient light sensor and a proximity sensor. The ambient light sensor includes an ambient light photodetector. The proximity sensor includes an infrared photoemitter, a reference infrared photodetector and another infrared photodetector. The ambient light sensor is arranged in a stack over the proximity sensor with a position that allows infrared photons transmitted by the infrared photoemitter to be received by the reference infrared photodetector.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 17, 2019
    Applicants: STMicroelectronics (Research & Development) Limited, STMicroelectronics (Grenoble 2) SAS
    Inventors: William HALLIDAY, Eric SAUGIER, Roy DUFFY
  • Benzimidazole derivatives as bromodomain inhibitors
    Patent number: 10442786
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • Ranging apparatus
    Patent number: 10436581
    Abstract: A distance sensing apparatus includes a light source configured to emit polarized light. A light sensitive detector detects light emitted by said light source and reflected from a target. The light sensitive detector is configured to substantially prevent polarized light reflected from a target with a relatively high reflectance from being detected.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: October 8, 2019
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Sam Lee, John Kevin Moore, Francescopaolo Mattioli Della Rocca
  • Pen
    Patent number: D863431
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: October 15, 2019
    Assignee: Fulon Development Limited
    Inventor: Peter M. H. Hung
  • Seedless table grape (grapevine) named ‘ARRATWENTYFOUR’
    Patent number: PP31111
    Abstract: A new distinct variety of grapevine named ARRATWENTYFOUR abundantly forms attractive moderately firm seedless berries with an attractive purple-black skin coloration; in semi-tight clusters which display a naturally sweet flavor. The fruit commonly is ready for harvesting during June in San Joaquin Valley of Central California, U.S.A, and displays good eating qualities as a table grape. The fruit meatiness and firmness renders the fruit amenable for handling, shipping, and storage.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: November 26, 2019
    Assignee: Agricultural Research and Development Limited Liability Company
    Inventor: Shachar Karniel