Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.

Abstract: The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relates to pharmaceutical compositions including a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an mTOR kinase inhibitor activity is indicated, and in particular the treatment of idiopathic pulmonary fibrosis.

Abstract: The present invention relates to or a pharmaceutically acceptable salt or ester prodrug thereof for use in the treatment of a mycobacterial infection or disease resulting from a mycobacterial infection, such as tuberculosis.

Abstract: Hepatitis C virus (HCV) infection is a leading cause for liver cirrhosis and hepatocellular carcinoma worldwide2. Current therapeutic regimens are usually poorly tolerated and only effective in a proportion of infected individuals. We discovered a peptide with sequence of DEAQETAVSSHEQD (SEQ ID NO: 1), a fragment of rabbit ?1-antiproteinase F, and its derivatives DEAQETAVSSHEQ (SEQ ID NO: 2) and QETAVSSHEQD (SEQ ID NO: 3), significantly inhibit serum-borne HCV replication in hADSC and human hepatocytes.

Abstract: A system, method, and computer program product are provided for automatically determining customer issues and resolving issues using graphical user interface (GUI) based interactions with a chatbot. In operation, a system implements a self-learning algorithm that keeps track of all activities and usages associated with a subscriber account. Further, the system prepares storylines based on the activities and usages. The storylines are used to automatically create hypothetical issues that a subscriber associated with the subscriber account may be facing. The system also provides a GUI based chat option to the subscriber to communicate with a chatbot. The GUI based chat option includes a graphical representation of created hypothetical issues, and also suggests solutions to the hypothetical issues.

Abstract: The present disclosure is directed to a diode including a first doped structure, doped with a first type of material and forming at least part of an isolation structure for the diode; at least one contact structure located within the first doped structure, the at least one contact structure forming one of the cathode or anode of the diode; a second doped structure, doped with a second type of material, and forming at least one depletion region or PN junction with the first doped structure; at least one second contact structure located within the second doped structure, the at least one second contact structure forming the other of the anode or the cathode of the diode; at least one further contact structure, doped with the first type of material, the at least one further contact structure forming at least one further depletion region or further PN junction, such that the at least one further depletion region is configured to steer charge from the at least one depletion region and thus decrease the sensitivity

Abstract: A system, method, and computer program product are provided for managing a plurality of heterogeneous services and/or a plurality of heterogeneous devices linked to at least one customer. In operation, a system links a customer identifier associated with at least one customer with one or more of a plurality of heterogeneous services and/or a plurality of heterogeneous devices. Moreover, the system manages the plurality of heterogeneous services and/or the plurality of heterogeneous devices linked to the customer(s).

Abstract: The present disclosure is directed to a fluidic ejection device configured to detect whether one or more nozzles of the fluidic ejection device is in a normal state, a blocked nozzle state, or an accumulated fluid state. The fluidic ejection device includes an optical blockage detector having a light emitting device configured to emit a light signal, and a light sensor configured to detect the light signal. The optical blockage detector detects the normal state, the blocked nozzle state, and the accumulated fluid state based on the detected light signal.

Abstract: The present invention relates to immunogenic compositions comprising an immunogenic polypeptide from Haemophilus influenzae or an immunogenic fragment thereof and/or an immunogenic polypeptide from Moraxella catarrhalis or an immunogenic fragment thereof, for use in the treatment or prevention of a recurrence of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) resulting from a bacterial infection in a subject.

Abstract: A method and system for analyzing real world information of users to derive physical (real world) user attributes used for selecting online content for presentation by client devices correlated with the users, comprising, detecting a presence of one or more users in a physical registration location by analyzing sensory data captured by one or more sensors deployed to monitor the physical registration location, correlating between the user(s) and an identifier of client device(s) associated with the user(s), identifying one or more user attributes of the user(s) by analyzing the sensory data and transmitting the user attribute(s) coupled with the identifier to one or more remote servers adapted to use the user attribute(s) for selecting one or more online content items served to the client device(s) via a network for presentation to the user(s). The sensor(s) is physically and communicatively disconnected from the client device(s).

Abstract: As described herein, a system, method, and computer program are provided for edge management of geographically dispersed sensors. An edge device within a network accesses observations of a plurality of geographically dispersed sensors. Additionally, the edge device processes the observations to determine overlapping portions of the observations. Further, the edge device optimizes the observations to form optimized observations for transmission to a cloud processing system, wherein the optimizing is based on the determined overlapping portions of the observations.

Abstract: A sensor has plurality of pixels arranged in a plurality of rows and columns with row control circuitry for controlling which one of said rows is activated and column control circuitry for controlling which of said pixels in said activated row is to be activated. The column circuitry has memory configured to store information indication as to which of the pixels are defective, wherein each of the pixels has a photodiode and a plurality of transistors which control the activation of the photodiode. A first transistor is configured to be controlled by a column enable signal while a second transistor is configured to be controlled by a row select signal.

Abstract: A system, method, and computer program product are provided for aggregating channel agnostic data. In use, channel agnostic data is received, at a messaging bus, from a plurality of telecommunication system sources, wherein the plurality of telecommunication system sources is channel agnostic. Next, using a micro service, the channel agnostic data is aggregated from the plurality of telecommunication system sources and the aggregated channel agnostic data is presented, on demand, based on at least one of authority, needs, and preferences. Further, at least one action is associated with the aggregated channel agnostic data.

Abstract: Disclosed herein is a method of determining an optimal route for a vessel based on vessel traffic data. The method comprises receiving vessel traffic data relating to the movement of each of a plurality of vessels in a geographical region and defining sub-regions within the geographical region in which the vessel traffic data has similar characteristics. The method also comprises determining an optimal route for a vessel between two geographical points using a representation of the geographical region. The representation comprises nodes, and each node is associated with a respective defined sub-region.

Abstract: As described herein, a system, method, and computer program are provided for closed loop management of a network. In use, a goal state is stored for a resource in a network. Additionally, an actual state of the resource is monitored. Further, divergence of the actual state of the resource from the goal state stored for the resource is detected, based on the monitoring. Still yet, a solution to return the actual state of the resource to the goal state is determined, where the solution includes a computed activity path that returns the actual state of the resource to the goal state. The solution is then executed to return the actual state of the resource to the goal state.

Abstract: A system, method, and computer program product are provided for automatically mapping business models to technical models. In use, business entity information and corresponding business entity fields are received for defining a business model. The business entity information is associated with one or more business entities selected by a user in accordance with a business request. Additionally, each business entity of the one or more business entities and the corresponding business entity fields are mapped to one or more technical entities and corresponding technical entity fields of a technical model. Further, an online translation of the business model to the technical model is performed such that changes or updates to the business model will cause changes or updates to the technical model, based on the mapping.

Abstract: A method and system for classifying a vehicle based on low frequency GPS tracks. The method and system comprise retrieving a low frequency GPS track having a sampling interval of at least 20 seconds; deriving additional data from the low frequency GPS track, the additional data including interval speed and instantaneous acceleration of the vehicle; extracting a plurality of data sets from the low frequency GPS track and the additional data; generating a plurality of features from the extracted data sets; and providing the plurality of generated features to a classifier that classifies the vehicle into a predetermined class.

Abstract: A load planning platform may generate, according to one or more loading rules, a preliminary packing solution that simulates placing unpacked items, in a set of items, into a container. The load planning platform may generate a set of packing solutions by applying one or more available moves to the preliminary packing solution. The load planning platform may select a final packing solution from the set of packing solutions based on one or more optimization criteria associated with the container and the set of items. The load planning platform may provide access to a three-dimensional rendering of the final packing solution that differentiates each item in the set of items based on a sequence in which the set of items are to be unloaded from the container.

Abstract: The present invention relates to methods of selecting, screening, engineering, making and modifying antibodies that have improved bioavailability upon subcutaneous administration to a human. Antibodies and variant antibodies with improved bioavailability upon subcutaneous administration to a human are also described.

Abstract: The invention relates to compounds of formula (I) which are inhibitors of kinase activity, pharmaceutical formulations containing the compounds and their uses in treating and preventing viral infections and disorders caused or exacerbated by the viral infection wherein R1, R2, R3, R4a, R4b, R4c, R5, W, X, Y and Z are defined herein.