Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

Abstract: A system, method, and computer program product are provided that utilize a decoy in response to a distributed denial of service attack in a communication network. In use, a distributed denial of service (DDoS) attack directed at one or more resources of a communication network is detected. Additionally, at least one first communication channel associated with the communication network that is subject to the DDoS attack is identified. Further, at least one second communication channel to implement functionality of the at least one first communication channel is initiated, while maintaining the at least one first communication channel subject to the DDoS attack to use as a decoy for the DDoS attack. Moreover, the at least one second communication channel is utilized to implement the functionality of the at least one first communication channel while the at least one first communication channel subject to the DDoS attack is used as the decoy for the DDoS attack.

Abstract: A system, method, and computer program product are provided for deploying a disk image in a communication network, based on network topology. In use, a disk image to be distributed in association with a communication network is identified, the communication network including a plurality of datacenters. Additionally, one or more of the plurality of datacenters in which to distribute the disk image are identified, based on one or more network topology characteristics associated with the communication network. Further, the disk image is distributed to the identified one or more of the plurality of datacenters. Still yet, a list indicating all of the plurality of datacenters that contain the disk image is sent to the plurality of datacenters.

Abstract: A system, method, and computer program product are provided for implementing optimal regression test strategies. In use, one or more functional testing entities are identified to be utilized to determine a scope associated with at least one regression test to be performed. The at least one regression test to be performed is associated with at least one change made to a functional system based on multi-dimensional modelling. Additionally, source code is mapped to the one or more functional testing entities, the source code being associated with the functional system. Further, a multi-dimensional impact score is calculated for each of the one or more functional testing entities resulting from the at least one change made to the functional system, based on the mapping of the source code to the one or more functional testing entities. Moreover, an output is generated showing impacted functional testing entities based on the multi-dimensional impact score for each of the one or more functional testing entities.

Abstract: An electronic device disclosed herein includes a single photon avalanche diode (SPAD) configured to detect an incoming photon and to generate a first pulse signal in response thereto. Pulse shaping circuitry is configured to generate a second pulse signal from the first pulse signal by high pass filtering the first pulse signal. The pulse shaping circuitry includes a transistor drain-source coupled between a first node and a reference node, and a capacitor coupling the first node to an anode of the SPAD.

Abstract: Disclosed are novel crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide and pharmaceutical compositions containing the same. Also disclosed are processes for the preparation thereof and methods for use thereof.

Abstract: A guidewire (1) for re-canalizing a vascular occlusion comprises a core wire (5) which terminates at its distal end (4) in a terminal member (7) for opening the occlusion. A helical coil sleeve (10) extends around the core wire (5) from the terminal member (7) to a location (11) along the core wire (5). The terminal member (7) defines first and second planar surface portions (13, 14), which converge towards a distal transversely extending leading edge portion (8). In use, as the terminal member (7) is urged through the vascular occlusion, the first and second surface portions (13, 14) act on the occlusion to form an opening therethrough. A distal portion (28) of the core wire (5) is of spade-like configuration for facilitating bending thereof for directing the terminal member (7) out of a central major plane (35) defined by the distal portion (28) for facilitating aligning of the terminal member (7) with a branched vessel of the vascular system.

Abstract: SPADs detect photons of a return light pulse and output corresponding pulse signals. First and second counters, when enabled in response to phase measurement value, are configured to count the pulse signals. The phase measurement value is set for a subsequent iteration of the return light pulse in response to processing of first and second count values of the first and second counters, respectively, for a current iteration. If the first count value exceeds the second count value by more than a difference threshold limit, the phase measurement value is decremented for the subsequent iteration. Otherwise, the phase measurement value is incremented for the subsequent iteration. If the difference threshold limit is not satisfied, the phase measurement value may be maintained for the subsequent iteration, but one of the counters is preloaded for the subsequent iteration with a value equal to a magnitude of the difference between the count values.

Abstract: A pixel is formed by two or more photodiodes and at least one transfer gate. The transfer gate is configured to transfer charge from each of the photodiodes to a common sense node, such that charge from the photodiodes is combined at the common sense node.

Abstract: A trial acetabular cup having a signal generating device located thereon.

Abstract: A shoe upper includes a mesh covering unit having opposite first and second surfaces and including a plurality offirst and second yarns, and a fabric layer disposed on the second surface. Each of the first yarns has a first core yarn, and a first coating layer wrapped around the first core yarn and made from a thermoplastic material. The first and second yarns are interknitted to form a plurality of holes extending through the first and second surfaces, and to have first portions of the first coating layers and first portions of the second yarns forming the first surface, and second portions of the first coating layers and second portions of the second yarns forming the second surface The first portions of the first coating layers at the first surface are larger in surface area than the second portions of the first coating layers at the second surface.

Abstract: A system, method, and computer program product are provided for calculating a customer value for communication service provider customers for network optimization and planning. In use, at least one customer of a communication service provider (CSP) is identified. The customer is identified to calculate a current customer value of the customer to the communication service provider. Additionally, a current location of the customer is identified based on a determined current location of a user device being utilized by the customer. Further, information associated with a current service being utilized by the customer on the user device being utilized by the customer is identified. Moreover, the current customer value of the customer to the communication service provider is calculated based on at least the current location of the customer and the current service being utilized by the customer.

Abstract: An electronic device disclosed herein includes a first integrated circuit die having formed therein photodiodes and readout circuitry for the photodiodes, with the readout circuitry including output pads exposed on a surface of the first integrated circuit die. A second integrated circuit die has formed therein storage capacitor structures for the photodiodes and digital circuitry for performing image processing on data stored in the storage capacitor structures, with the storage capacitor structures including input pads exposed on a surface of the second integrated circuit die. The first and second integrated circuit die are in a face to face arrangement such that the output pads of the first integrated circuit die face the input pads of the second integrated circuit die. An interconnect couples the output pads of the first integrated circuit die to the input pads of the second integrated circuit die.

Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.

Abstract: A sensing apparatus includes a sensor and a processor. The sensor includes at least one light sensitive detector. The processor determines a first control value to control a voltage differential across the at least one light sensitive detector, and compares the first control value with a reference value associated with a reference temperature. Based on the comparison, the processor provides adjustment information for adjusting at least one output of the sensing apparatus, and an operating parameter of the sensing apparatus other than the voltage differential.

Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

Abstract: A time of flight detector includes an electromagnetic radiation emitter configured to emit a beam of radiation. A first optical element receives the beam of radiation and generates a collimated beam of radiation. A second optical element defines a narrow imaging field of view sufficient to capture reflected electromagnetic radiation from the collimated beam. An electromagnetic radiation sensor then senses the captured reflected electromagnetic radiation from the collimated beam in the narrow imaging field of view. Further narrowing of the imaging field of view is accomplished by selective enabling a sub-array of photosensitive elements with the electromagnetic radiation sensor.

Abstract: Compound of formula (I) wherein: R1 is heteroaryl either unsubstituted or substituted by methyl, ethyl, halo or ?O; and R2 is H, methyl or ethyl; and salts thereof are KMO inhibitors and may be useful in the treatment of various disorders, for example acute pancreatitis, chronic kidney disease, acute kidney disease, acute kidney injury, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, HIV infection, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

Abstract: A portable lightweight exercise device that utilizes elastomeric bands, such as resistance bands, and pulleys to provide a multitude of exercises that target the glutes, thighs, and calf muscles of the legs.

Abstract: Photoluminescence from a sample detector is detected using an array of photo-sensitive detectors. At least one first photo-sensitive detector of the array is provided with a first type of linear polarization filter and at least one second photo-sensitive detector is provided with a second type of linear polarization filter. The first type of linear polarization filter has a plane of polarization which is at angled with respect to a plane of polarization of said second type of polarization filter.