Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.

Abstract: An electronic device includes at least one photodetection block, where the at least one photodetection block includes a plurality of macropixels arranged into an array. Each macropixel includes an array of photodiodes, with logic circuitry coupled to outputs of the array of photodiodes and configured to generate a detection signal as a function of logically combining the outputs of the array of photodiodes. Each macropixel has associated therewith selection circuitry configured to selectively pass the detection signal to output combining logic or to output combining logic of at least one neighboring macropixel of the plurality thereof. The output combining logic has inputs coupled to the selection circuitry and to the selection circuitry of the at least one neighboring macropixel, and is configured to generate an output detection signal as a function of logically combining outputs of the selection circuitry and the selection circuitry of the at least one neighboring macropixel.

Abstract: A system, method, and computer program product are provided for implementing a marketplace for edge computing. In use, a service request is received, at a network communication operator, from a first entity, the service request comprising an edge computing operator of an edge computing service, wherein the first entity is one of a request originator, a customer using a software service, a software service operator providing the software service, or a cloud computing operator providing a computing service to the software service. Additionally, the service request is distributed to at least one second entity, using the network communication operator, wherein the at least one second entity includes at least one of a first request mediator or a second request mediator. Further, the service request is distributed, using the network communication operator, to the edge computing operator.

Abstract: The present invention relates to a method of detecting nucleic acid in a sample comprising a flocculant and a recombinant protein, the method comprising (a) adding heparin and a detergent to the sample, (b) amplifying at least a portion of the nucleic acid, and (c) detecting the amplification in step (b), thereby detecting the nucleic acid in the sample. The present invention also relates to a method of detecting nucleic acid in a sample comprising a flocculant and a recombinant protein, the method comprising (a) adding a detergent and sodium hydroxide to the sample, (b) amplifying at least a portion of the nucleic acid, and (c) detecting the amplification in step (b), thereby detecting the nucleic acid in the sample.

Abstract: A method for acquiring tracking points belonging to a trajectory of a target object in motion, includes: emitting a radiation towards the target object; receiving a reflection of the radiation from the target object in respective fields of view of each detection zone of a network of detection zones; processing the reflection by determining distances separating the target object from an origin point by measuring a time of flight of the radiation in each detection zone; determining a degree of coverage of each detection zone; and estimating, based on the distances and on the degree of coverage of each detection zone, a position of a tracking point corresponding to a position of an extremity of the target object inside a respective detection zone chosen in a direction of motion of the target object.

Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.

Abstract: An optical sensor includes pixels. Each pixel has a photodetector and a semiconductor guard ring around the photodetector. The photodetector and the semiconductor guard ring are dimensioned so that a fill factor of the pixel is less than or equal to 50%.

Abstract: The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators.

Abstract: The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.

Abstract: The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by Mycobacterium, such as tuberculosis.

Abstract: The present disclosure is directed to an electronic device including a sensor having a transmission module configured to provide a plurality of collimated light beams. The transmission module includes a light source and a transmission beam splitter. The transmission beam splitter includes a plurality of lenslets. The transmission beam splitter is configured to receive one or more light beams from the light source and refract the one or more light beams for forming the plurality of collimated light beams.

Abstract: Embodiments of this disclosure include a cleaner attachment device, and may include a device for attachment to a vacuum or pressure cleaner. Embodiments may include an attachment for cleaning behind water heaters or in other narrow spaces and may include an elongate body with a plurality of apertures arranged helically along the body, and a plurality of resiliently deformable portions arranged along the body and extending from the body.

Abstract: A system, method, and computer program are provided for protecting against unintentional deletion of an eSIM from a mobile device. In use, deletion of an eSIM from a mobile device is detected. Additionally, definitions of predefined scenarios indicative of unintentional deletions of eSIMs are accessed. Further, the detected deletion is analyzed, using the definitions, to determine that the detected deletion is unintentional. Still yet, a proactive care action is caused to be performed to address the unintentional deletion of the eSIM from the mobile device.

Abstract: The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.

Abstract: A system, method, and computer program product are provided for determining and marking on a document what may be of interest to a user. In operation, a system identifies at least one document of potential interest to at least one user. The system identifies interest points associated with the at least one document for the at least one user based on one or more of: previously identified interest points in the at least one document, previously identified interest points in other similar documents, and characteristics of the at least one document. Further, the system marks in the at least one document the identified interest points associated with the at least one document for easy viewing by the at least one user.

Abstract: A system, method, and computer program product are provided for performing user interface synchronization. In use, a first event occurring at a first application is identified within a system, the first event including a displaying of first information within a first user interface (UI) of the first application. Additionally, identification information associated with the first event is retrieved. Further, the first information displayed within the first UI of the first application is synchronized with second information displayed within a second UI of a second application within the system, utilizing the identification information associated with the first event.

Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

Abstract: A pixel includes a single photon avalanche diode (SPAD) having a cathode coupled to a high voltage supply through a quenching element, with the SPAD having a capacitance at its anode formed from a deep trench isolation, with the quenching element having a sufficiently high resistance such that the capacitance is not fully charged when the SPAD is struck by an incoming photon. The pixel includes a clamp transistor configured to be controlled by a voltage clamp control signal to clamp voltage at an anode of the SPAD when the SPAD is struck by an incoming photon to be no more than a threshold clamped anode voltage, and readout circuitry coupled to receive the clamped anode voltage from the clamp transistor and to generate a pixel output therefrom. The threshold clamped anode voltage is below a maximum operating voltage rating of transistors forming the readout circuitry.

Abstract: A new distinct variety of grapevine named ‘ARRATHIRTYTHREE’ abundantly forms attractive crisp seedless berries with a creamy yellow-green skin coloration; lax small-medium clusters which display a light muscat flavor. The fruit commonly is ready for harvesting during the end of June in San Joaquin Valley of Central California, U.S.A., and displays good eating qualities as a table grape. The fruit firmness renders the fruit well amenable for handling, shipping, and storage.