Patents Assigned to DexCom, Inc.
  • Device and method for determining analyte levels
    Patent number: 8155723
    Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: April 10, 2012
    Assignee: DexCom, Inc.
    Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes, Barbara J. Gilligan, Mark A. Tapsak
  • Systems and methods for replacing signal artifacts in a glucose sensor data stream
    Patent number: 8150488
    Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: April 3, 2012
    Assignee: DexCom, Inc.
    Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James Patrick Thrower, Victoria Carr-Brendel
  • ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM
    Publication number: 20120078071
    Abstract: Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.
    Type: Application
    Filed: September 28, 2011
    Publication date: March 29, 2012
    Applicant: DexCom, Inc.
    Inventors: Sebastian Bohm, Mark Dervaes, Eric Johnson, Apurv Ullas Kamath, Shawn Larvenz, Jacob S. Leach, Phong Lieu, Aarthi Mahalingam, Tom Miller, Paul V. Neale, Jack Pryor, Thomas A. Peyser, Daiting Rong, Kenneth San Vicente, Mohammad Ali Shariati, Peter C. Simpson, Matthew Wightlin
  • Analyte sensor
    Patent number: 8133178
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: March 13, 2012
    Assignee: DexCom, Inc.
    Inventors: James H. Brauker, Apurv U. Kamath
  • Systems and methods for replacing signal artifacts in a glucose sensor data stream
    Patent number: 8128562
    Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: March 6, 2012
    Assignee: DexCom, Inc.
    Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James Patrick Thrower, Victoria Carr-Brendel
  • ANALYTE SENSING BIOINTERFACE
    Publication number: 20120046534
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Application
    Filed: October 31, 2011
    Publication date: February 23, 2012
    Applicant: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • Porous membranes for use with implantable devices
    Patent number: 8118877
    Abstract: A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: February 21, 2012
    Assignee: DexCom, Inc.
    Inventors: James H. Brauker, Mark A. Tapsak, Mark C. Shults
  • TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS
    Publication number: 20120040101
    Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: DexCom, Inc.
    Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
  • SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS
    Publication number: 20120035445
    Abstract: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
    Type: Application
    Filed: October 20, 2011
    Publication date: February 9, 2012
    Applicant: DexCom, Inc.
    Inventors: Robert Boock, Monica Rixman
  • SYSTEMS AND METHODS FOR COMMUNICATING SENSOR DATA BETWEEN COMMUNICATION DEVICES
    Publication number: 20110320130
    Abstract: System and method for communicating glucose concentration information between devices of a continuous glucose monitoring system is provided. The continuous glucose monitoring system can include a sensor module generates a glucose concentration measurement data and transmits the data to one or more further devices of the continuous glucose monitoring system. The further devices can include a receiver unit and one or more secondary display devices. The receiver unit can be configured to be a stand-alone device of or physically connect to a secondary display device. A user interface can also be provided that provides enhanced functionality for using the continuous glucose monitoring system.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 29, 2011
    Applicant: DEXCOM, INC.
    Inventors: Jorge Valdes, Shawn Larvenz, MIchael Robert Mensinger, Hari Hampapuram, Kostyantyn Snisarenko, Phil Mayou, Eli Reihman, Randy Tompot
  • CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR
    Publication number: 20110319739
    Abstract: Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Application
    Filed: September 7, 2011
    Publication date: December 29, 2011
    Applicant: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, Peter C. Simpson, James H. Brauker, Paul V. Goode, JR.
  • POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES
    Publication number: 20110313543
    Abstract: A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
    Type: Application
    Filed: August 15, 2011
    Publication date: December 22, 2011
    Applicant: DexCom, Inc.
    Inventors: James H. Brauker, Victoria Carr-Brendel, Mark A. Tapsak
  • Systems and methods for replacing signal artifacts in a glucose sensor data stream
    Patent number: 8073519
    Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: December 6, 2011
    Assignee: DexCom, Inc.
    Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James Patrick Thrower, Victoria Carr-Brendel
  • Systems and methods for replacing signal artifacts in a glucose sensor data stream
    Patent number: 8073520
    Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: December 6, 2011
    Assignee: DexCom, Inc.
    Inventors: Apurv U. Kamath, Paul V. Goode, Jr., James H. Brauker, James Patrick Thrower, Victoria Carr-Brendel
  • TRANSCUTANEOUS ANALYTE SENSOR
    Publication number: 20110290645
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Application
    Filed: June 9, 2011
    Publication date: December 1, 2011
    Applicant: DexCom, Inc.
    Inventors: Mark Brister, Paul V. Neale, Peter C. Simpson, James H. Brauker, James Patrick Thrower, Mark Shults, Rathbun K. Rhodes, Paul V. Goode, JR., Arnold L. Holmquist
  • Silicone based membranes for use in implantable glucose sensors
    Patent number: 8064977
    Abstract: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: November 22, 2011
    Assignee: DexCom, Inc.
    Inventors: Robert Boock, Monica Rixman
  • System and methods for processing analyte sensor data
    Patent number: 8060173
    Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: November 15, 2011
    Assignee: DexCom, Inc.
    Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James P. Thrower
  • Analyte sensing biointerface
    Patent number: 8060174
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 15, 2011
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
    Publication number: 20110275919
    Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
    Type: Application
    Filed: July 20, 2011
    Publication date: November 10, 2011
    Applicant: DexCom, Inc.
    Inventors: James Petisce, Mark A. Tapsak, Peter C. Simpson, Victoria Carr-Brendel
  • Dual electrode system for a continuous analyte sensor
    Patent number: RE43039
    Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: December 20, 2011
    Assignee: DexCom, Inc.
    Inventors: Mark Brister, James R. Petisce, Peter C. Simpson, James H. Brauker