Abstract: Diagnostic method(s) for detecting and treating post-infarct myocardial remodeling and diffuse myocardial fibrosis.

Abstract: Embodiments are directed to a transfer arm with a probe and a crash detection mechanism for use in a clinical analyzer in an in vitro diagnostics environment. The mechanism requires no user-intervention after a collision event, unless the automated inspection mechanism determines that damage to the probe requires probe replacement. Moreover, the mechanism is capable of protecting the probe, in some instances, from damage during a collision. The mechanism provides for automatic resetting after a collision, self-checking, and alignment correction. The mechanism includes a crash detection printed circuit assembly with a switch, and a spring-loaded contact sensor assembly configured to secure a probe within the transfer arm and allow for electrical connection between the switch and the probe during normal operation and electrical disconnection between the switch and the probe upon contact of the probe with an obstruction.

Abstract: A wash station comprises a wash nozzle for cleaning an exterior portion of a probe and a basin allowing for waste fluid to be collected. The wash nozzle comprises a vertically-elongate cavity with side slits on opposing side portions. A fluid inlet port may be connected to a side portion of the cavity to provide fluid. Fluid may additionally or alternatively come from within the probe. The basin comprises an elongate body with an opened end to receive and secure the wash nozzle. One or more access slots may be provided on opposing side portions of the basin. The probe passes through an access slot or over a portion of the basin and through a side slit of the nozzle to enter the cavity for cleaning. A geometry of the cavity allows the wash nozzle to fill to a predetermined level while waste fluid flows out through the side slits.

Abstract: A system includes a sample analyzer having a sensor assembly. The sensor assembly includes a first microsensor having a first outer sheath, a first membrane core within the first outer sheath, and a first conductive element at least partially encased by and in contact with the first membrane core. The first conductive element detects a first electrical response signal when the first membrane core is in contact with the fluid. The sensor assembly may include a second microsensor that is adjacent to the first microsensor. The second microsensor has a second outer sheath, a second membrane core within the outer sheath, and a second conductive element at least partially encased by and in direct contact with the second membrane core. The second conductive element detects the second electrical response signal when the second membrane core is in contact with the fluid.

Abstract: The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.

Abstract: Non-limiting embodiments of an improved Müllerian Inhibiting Substance storage buffer composition(s) and method(s) of stabilizing a Müllerian Inhibiting Substance in the improved storage buffer composition.

Abstract: The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences are also provided assembled as kits that can be used to amplify and detect or sequence HCV NS3.

Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.

Abstract: A monitor recorder optimized for electrocardiography and respiratory data acquisition and processing is provided.

Abstract: An electrocardiography patch is provided. A backing forms an elongated strip with a mid-section connecting two ends of the backing. The mid-section is narrower than the two ends of the backing. An electrocardiographic electrode is provided on each end of the backing to capture electrocardiographic signals. A flexible circuit includes a pair of circuit traces electrically coupled to the electrocardiographic electrodes. A wireless transceiver communicates at least a portion of the electrocardiographic signals.

Abstract: Methods are disclosed for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,500. The method comprises the use of a first antibody that binds to the small molecule and a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a hapten that is not the small molecule or a derivative of the small molecule wherein the hapten comprises a moiety that is structurally similar to that of the second portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.

Abstract: Provided herein are color charts and water color pigment solutions useful, for example, in the calibration of reflectance-based diagnostic analyzers.

Abstract: A method for producing silicate-containing magnetic particles having a closed and tight silicate layer and high purity. In addition, the novel method prevents an uncontrolled formation of aggregates and clusters of silicates on the magnetite surface, thereby having a positive influence on the properties and biological applications. The method enables depletion of nanoparticulate solid substance particles on the basis of a fractionated centrifugation. The silicate-coated magnetic particles exhibit optimized magnetization and suspension behavior as well as advantageous run-off behavior from plastic surfaces. These highly pure magnetic particles coated with silicon dioxide are preferably used for isolating nucleic acids from cell and tissue samples, whereby the separating out from a sample matrix ensues by means of magnetic fields.

Abstract: A computer-implemented method for performing photometric cuvette mapping includes detecting edges associated with a plurality of gaps between a plurality of vessels in a reaction ring during a complete rotation of a reaction ring. Each gap is determined according to an edge detection process which includes identifying: a vessel interior in response to detection of a first predetermined number of photometer device control manager (DCM) measurements below a threshold value; a rising edge in response to detection of a second predetermined number of photometer DCM measurements above the threshold value; and identifying a falling edge in response to detection of a third predetermined number of photometer DCM measurements below the threshold value. The edge detection process further includes recording the rising edge and the falling edge as being indicative of one of the plurality of gaps.

Abstract: Nanodiamond particles and related devices and methods, such as nanodiamond particles for the detection and/or quantification of analytes, are generally described. In some embodiments, the device comprises a plurality of nanodiamond particles and a species bound to the nanodiamond particles. In certain embodiments, the plurality of nanodiamond particles may be exposed to a sample suspected of containing an analyte. In some cases, the analyte may bind to the species such that the presence of the analyte in the sample may be detected. In some embodiments, the devices, systems, and methods described herein are useful for the detection of an analyte in a sample obtained from a subject for, for example, diagnostic purposes. In some cases, the systems, devices, and methods described herein may be useful for diagnosing, prevent, treating, and/or managing a disease or bodily condition.

Abstract: Systems and methods for detecting udder disease based on machine learning methods and complementary supporting techniques are presented. Included are methods for assembling time sequences of images of each animal of a herd or set for subsequent use in per-animal image analysis for disease detection. Methods presented also include image pre-processing methods used prior to image analysis, resulting in contrast and resolution optimization such as appropriate image intensity level adjustment and resolution downsampling for more rapid and more accurate disease detection. Combinatorial techniques for compositing whole-udder images or udder-quarter images from partial images captures are described. Methods are provided for power usage optimization in regard to computing resources used in the computing-intensive AI analysis methods. Location-based and animal history-based detection refinements are incorporated into described systems.

Abstract: A mask for performing an eye exam of a subject includes one or more optically transparent sections for transmitting an incident light beam therethrough and incident on the subject's eye, in some embodiments, the one or more optically transparent sections are coated with an anti-reflective coating configured to reduce reflection of the incident light beam by the one or more optically transparent sections. In some embodiments, the one or more optically transparent sections may have a portion thereof that is tilted with respect to the incident light beam when the mask is optically interfaced with the docking portion of an ophthalmic instrument, such that the incident light beam forms a finite angle of incidence with respect to the corresponding portion of the optically transparent sections.

Abstract: A model-based method of determining characteristics of a specimen container. The method includes providing a specimen container, capturing images of the specimen container at different exposures times and at different spectra having different nominal wavelengths, selecting optimally-exposed pixels from the images at different exposure times at each spectra to generate optimally-exposed image data for each spectra, and classifying the optimally-exposed pixels as at least being one of tube, label or cap, and identifying a width, height, or width and height of the specimen container based upon the optimally-exposed image data for each spectra. Quality check modules and specimen testing apparatus adapted to carry out the method are described, as are other aspects.

Abstract: An embodiment of the present disclosure is a sample collection unit configured to receive a test strip. The sample collection unit includes a collection tube including an open end and a cap configured to be coupled to the open end to close the collection tube. The cap includes an access opening that extends through the cap and at least one sealing member aligned with the access opening. The at least one sealing member includes a dynamic strip interface that permits insertion of the test strip through the access opening and into the collection tube.

Abstract: Devices, kits, and methods for dispensing at least two liquid reagents for use in analyte(s) detection assays are disclosed.