Patents Assigned to Diagnostics, Inc.
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Publication number: 20210012869Abstract: A health pass system for COVID-19 is provided. The system includes a database including information on a plurality of individuals. The database is configured to receive point-of-care data relating to the plurality of individuals, the point-of-care data including at least one medical test result for COVID-19 antibodies for at least one of the plurality of individuals. The system includes a processing device configured to analyze the point-of-care data and generate a report. The system includes means for transmitting the report to a mobile electronic device of at least one of the plurality of individuals. The system includes means for displaying the report with a user interface of the mobile electronic device in the form of a real-time health certification.Type: ApplicationFiled: September 29, 2020Publication date: January 14, 2021Applicant: Biosafety Diagnostics, Inc.Inventors: Michael Kotlarz, Keith Barksdale
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Patent number: 10888239Abstract: A remotely-interfaceable electrocardiography patch is provided. The remotely-interfaceable electrocardiography patch includes a backing formed of a strip of material and an electrocardiographic electrode on each end of the backing to capture electrocardiographic signals. A flexible circuit includes a pair of circuit traces electrically coupled to the electrocardiographic electrodes. A wireless transceiver communicates at least one of the electrocardiographic signals and other physiological measures with one or more of a physiology and activity sensor, communication device, server, and personal computer.Type: GrantFiled: January 7, 2019Date of Patent: January 12, 2021Assignee: Bardy Diagnostics, Inc.Inventors: Jason Felix, Jon Mikalson Bishay, Gust H. Bardy
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Publication number: 20210003596Abstract: Chemiluminescent androstenedione conjugates are disclosed. These chemiluminescent androstenedione conjugates may be used as chemiluminescent tracers in immunoassays for the quantification and identification of certain analytes.Type: ApplicationFiled: February 23, 2018Publication date: January 7, 2021Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Yi Feng Zheng, Lauren Parker, John Driscoll, Zhijian Zhao, Patrick Donovan
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Patent number: 10884572Abstract: Windows corresponding to independent applications in a windowed computing environment can be linked to have unified behavior. A host application can monitor window activity to determine if windows are intended to be grouped. Commands applied to one or more windows in a group are applied to at least some other windows in the group. Windows can be grouped or ungrouped according to various criteria including a priori configuration or user action. The window grouping permits a unified user interface behavior to be established for two or more independent applications.Type: GrantFiled: June 7, 2018Date of Patent: January 5, 2021Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Michael Heydlauf
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Patent number: 10883983Abstract: A device for the detection of a target analyte in solution is provided. The device comprises a gate-keeper membrane made of a substrate having a first receptor surface for exposure to the target analyte and a second opposing surface exposed to a detector, wherein the substrate is adapted to incorporate pores sufficient to permit passage of a reporter through the membrane from exposure to the first receptor surface to the second opposing surface; one or more receptors anchored on the first surface of the substrate which bind with the target analyte, wherein binding of the receptor with the target analyte alters the passage of the reporter through the pores of the membrane; and one or more detectors which interact with reporter that passes through the membrane and emits a detectable signal that permits quantification of reporter in the detection reservoir.Type: GrantFiled: October 11, 2016Date of Patent: January 5, 2021Assignee: LeNano Diagnostics Inc.Inventor: Xiaowu Tang
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Patent number: 10883957Abstract: A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.Type: GrantFiled: February 5, 2020Date of Patent: January 5, 2021Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Wei Zhang, Kevin Horan
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Patent number: 10887555Abstract: A depth-sensitive system for monitoring for and detecting a predefined condition at a specific location within a visually monitored portion of an area. Plural depth-sensitive cameras are oriented with respect to the area whereby each camera has a field of view within the area that at least partially overlaps with the field of view of another of the plural cameras. The combined field of view encompasses all portions of interest of the area. A system for providing a notification of the visual detection of a predefined condition at a particular location or set of locations within an area of interest is provided, as is a system for generating a visual representation of human activity at one or more specific locations within an area of interest.Type: GrantFiled: August 8, 2018Date of Patent: January 5, 2021Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Michael Heydlauf
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Publication number: 20200411134Abstract: Provided are methods and systems for determining the clinical significance of a genetic variant. The methods entail determining, for the variant, (a) a function score based on known impact of the variant on a biological function of a cell or protein, (b) a frequency score based on the frequency of the variant in a population, (c) a co-occurrence score based on how the variant co-occurs with a reference variant having known clinical significance relating to a clinical disease or condition, and (d) a family segregation score based on how the variant segregates with a disease or condition in a family; and aggregating, on a computer, the function score, the frequency score, the co-occurrence score, the family segregation score to generate a clinical significance score indicating the clinical significance of the genetic variant.Type: ApplicationFiled: August 28, 2020Publication date: December 31, 2020Applicant: Athena Diagnostics, Inc.Inventors: Izabela KARBASSI, Christopher ELZINGA, Glenn MASTON, Joseph HIGGINS, Sat DEV BATISH, Christina DIVINCENZO, Michele MCCARTHY, Jennifer LAPIERRE, Felicita DUBOIS, Katelyn MEDEIROS, Jeffery JONES, Corey BRAASTAD
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Patent number: 10871427Abstract: A biological liquid collection vessel is adapted to contain a biological liquid to be centrifuged. The collection vessel has a vessel body having an open upper end and a closed lower end, a continuous wall, a target area at the upper end, and a solids area at the lower end that is connected to the target area. The target area is extended in length. In some embodiments, a volume capacity of both of the target area and the solids area are configured so that a red blood cell portion of the centrifuged biological liquid (e.g., blood) is substantially contained in the solids area, and the serum or plasma portion of the centrifuged biological liquid is substantially contained in the target area. Methods of and systems using the liquid collection vessels are provided, as are other aspects.Type: GrantFiled: August 1, 2013Date of Patent: December 22, 2020Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Alex Hsu, Scott Salmon, Radu Saftoiu
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Patent number: 10870109Abstract: A cup used to receive, hold, measure and pour liquids, such a specimens, such as for a medical assay, is described. The cup comprises an open receiving upper chamber, two or more open sample-directing channels, and an open, calibrated and marked measuring column. When sitting on a level surface, fluid flows freely from the upper chamber through the sample-directing channels into the measuring column. A foot is under each fluid-directing channel. The base of the measuring column functions as an additional, such as a third, foot. Cups nest, with the two feet of the upper cup sitting into two sample-directing columns of lower cup. The measuring column and upper chamber taper to permit nesting. If the cup is tipped, it rests on two of three of: the two feet and the base of the measuring column, and a point on a lower perimeter of the upper chamber, such that fluid will not spill.Type: GrantFiled: May 20, 2017Date of Patent: December 22, 2020Assignee: Sandstone Diagnostics, Inc.Inventors: Ulrich Schaff, Jon Epperson, Laura Fredriksen, Kirk Harmon
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Patent number: 10870110Abstract: A device and method for separating serum or plasma from blood cells in a whole blood specimen. The present invention uses a cap with a reservoir, such that blood cells are packed into the cap when the specimen container is centrifuged. When the cap is removed, the blood cells are also removed, and the serum or plasma is left in the specimen tube where it can be readily extracted by a pipette which is able to reach all the way to the bottom of the specimen tube minimizing the dead volume.Type: GrantFiled: December 12, 2016Date of Patent: December 22, 2020Assignee: Babson Diagnostics, Inc.Inventor: Eric Olson
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Publication number: 20200394586Abstract: Methods of and apparatus controlling change-out inventory of an automated analyzer apparatus. The inventory control methods include receiving change-out inventory status from automated analyzer apparatus at a server, receiving an estimate of the planned workload over a specific time period at the server, analyzing with a decisioning module of the server first data of the change-out inventory status and second data of the planned workload over the specified time period, and producing a work plan itinerary as an output from the decisioning module. The work plan itinerary provides sequence instructions or commands for an operator (person and/or robotic mechanism) to follow for changing out of change-out inventory items. Inventory control apparatus configured to carry out the methods are provided, as are other aspects.Type: ApplicationFiled: January 25, 2019Publication date: December 17, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Michael Heydlauf, Jeffrey Hoffman
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Publication number: 20200392582Abstract: The present invention relates to a hierarchical model for detecting colorectal tumors and an application thereof, wherein the model grades the change of an imprinted gene in a colorectal tumor by means of calculating the defect expression amount of the imprinted gene, copy number variation expression amount of the imprinted gene and total expression amount of the imprinted gene. The described detection model and device visually express the performance of imprinting defect in the tissue and cell samples of a colorectal tumor patient, and detect the change in an imprinted gene objectively, visually, early and accurately by means of the method of in situ labeling for the imprinted gene. In addition, the detection model and device may provide quantitative models, which makes a significant contribution to the diagnosis of colorectal tumors.Type: ApplicationFiled: August 30, 2018Publication date: December 17, 2020Applicant: Lisen Imprinting Diagnostics, Inc.Inventors: Tong CHENG, Ning ZHOU
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Publication number: 20200395121Abstract: Methods, apparatus, and systems for obtaining sensor-generated data in a diagnostic laboratory apparatus including one or more producers of data that include a sensor, a local communications network communicatively coupling the producers to a data router configured to translate data received from producers of data into a common format record, the common format including key-value pairs, and at least one subscriber that registers one or more channel-based subscriptions with the data router. Records remain in storage by the data router until to the subscriber acknowledges successful receipt, after which the data router manages its storage resources to provide storage for newer sensor-generated data. The data router is configured to install plug-ins as needed to translate data formats of newly-integrated producers with new formats.Type: ApplicationFiled: March 7, 2019Publication date: December 17, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Brian Heilig, Jeffrey Hoffman
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Publication number: 20200396291Abstract: Methods and apparatus for publisher-independent auxiliary communications in data router-mediated publisher/subscriber transmission architectures provide faster processing of actionable information by subscribers and increased flexibility to add publishers to a system. Publisher-originated information in a publisher-specific format is used by either the publisher, or a data router coupled to the publisher, to generate information, based on the publisher-originated information, in a publisher-independent format recognized by subscribers, and provided by the data router to subscribers. Publishers may include analyzers such as blood, immuno-assay, and clinical chemistry analyzers, IoT devices, and automation systems.Type: ApplicationFiled: January 25, 2019Publication date: December 17, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventor: Michael HEYDLAUF
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Publication number: 20200393479Abstract: Clinical analyzers including cuvette loading assemblies are described. A clinical analyzer includes a first location and a second location. A chute extends between the first location and the second location, wherein the chute is configured to enable cuvettes to slide from the first location to the second location. The clinical analyzer includes a loading assembly including two gates, each moveable between a first position where cuvettes are enabled to slide along the chute and a second position where cuvettes are blocked from sliding along the chute. Methods of transporting cuvettes in a clinical analyzer are also disclosed.Type: ApplicationFiled: February 20, 2019Publication date: December 17, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventor: Beri Cohen
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Patent number: 10864522Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: August 15, 2019Date of Patent: December 15, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Publication number: 20200385807Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.Type: ApplicationFiled: June 24, 2020Publication date: December 10, 2020Applicant: Athena Diagnostics, Inc.Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
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Publication number: 20200388389Abstract: A point of care system may comprise a plurality of diagnostic engines and an IDM in electronic communication with each of the plurality of diagnostic engines. Each of the plurality of diagnostic engines may perform testing on a sample inserted into the diagnostic engine. The IDM may be configured to communicate with each of the plurality of diagnostic engines to enable a plurality of tests to be performed on multiple different samples substantially simultaneously by a plurality of users using the plurality of diagnostic engines and to present a single user interface for managing testing by the plurality of diagnostic engines and for receiving the results of tests performed by each of the plurality of diagnostic engines.Type: ApplicationFiled: November 16, 2018Publication date: December 10, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Manish Deshpande, William Thorpe
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Publication number: 20200386777Abstract: Automated diagnostic analysis apparatus for analyzing patient specimens may include a probe to aspirate and dispense a bio-liquid. A probe tip on the probe may require replacement after contact with each bio-liquid. The automated diagnostic analysis apparatus may include a probe tip eject device and a waste chute for controlled removal and disposal of the probe tip to mitigate splattering or splashing of any residual bio-liquid in the probe tip as it is removed from the probe. A sloped ramp in the probe tip eject device may engage and remove the probe tip as it rotates through the probe tip eject device. The waste chute may include guides to transfer a removed probe tip directly into a waste bin without any surface contact by the probe tip. Methods of removing and disposing of a probe tip in an automated diagnostic analysis apparatus are described, as are other aspects.Type: ApplicationFiled: November 16, 2018Publication date: December 10, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Toby Ballen, Frank Bakonyi, Steffen Pharai, Domenick Ansalone
