Patents Assigned to Diagnostics, Inc.
  • Processing cartridge and method for detecting a pathogen in a sample
    Patent number: 10864522
    Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 15, 2020
    Assignee: GenMark Diagnostics, Inc.
    Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
  • MULTIPLE DIAGNOSTIC ENGINE ENVIRONMENT
    Publication number: 20200388389
    Abstract: A point of care system may comprise a plurality of diagnostic engines and an IDM in electronic communication with each of the plurality of diagnostic engines. Each of the plurality of diagnostic engines may perform testing on a sample inserted into the diagnostic engine. The IDM may be configured to communicate with each of the plurality of diagnostic engines to enable a plurality of tests to be performed on multiple different samples substantially simultaneously by a plurality of users using the plurality of diagnostic engines and to present a single user interface for managing testing by the plurality of diagnostic engines and for receiving the results of tests performed by each of the plurality of diagnostic engines.
    Type: Application
    Filed: November 16, 2018
    Publication date: December 10, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Manish Deshpande, William Thorpe
  • METHODS TO DETECT A SILENT CARRIER GENOTYPE
    Publication number: 20200385807
    Abstract: Provided herein are methods and compositions for the detection of silent carriers of chromosomal deletion alleles in a human subject using haploid cells (e.g., sperm cells or egg cells) derived from the subject. The methods provided herein allow for the detection of silent (2+0) carriers of SMA, where the individual has a deletion of the SMN1 gene on one chromosome 5 homolog and two or more copies of the SMN1 gene on the other chromosome 5 homolog.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 10, 2020
    Applicant: Athena Diagnostics, Inc.
    Inventors: David A. Hill, Matthew Evans, Corey D. Braastad
  • PROBE TIP WASTE CHUTES AND METHODS THEREOF FOR AUTOMATED DIAGNOSTIC ANALYSIS APPARATUS
    Publication number: 20200386777
    Abstract: Automated diagnostic analysis apparatus for analyzing patient specimens may include a probe to aspirate and dispense a bio-liquid. A probe tip on the probe may require replacement after contact with each bio-liquid. The automated diagnostic analysis apparatus may include a probe tip eject device and a waste chute for controlled removal and disposal of the probe tip to mitigate splattering or splashing of any residual bio-liquid in the probe tip as it is removed from the probe. A sloped ramp in the probe tip eject device may engage and remove the probe tip as it rotates through the probe tip eject device. The waste chute may include guides to transfer a removed probe tip directly into a waste bin without any surface contact by the probe tip. Methods of removing and disposing of a probe tip in an automated diagnostic analysis apparatus are described, as are other aspects.
    Type: Application
    Filed: November 16, 2018
    Publication date: December 10, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Toby Ballen, Frank Bakonyi, Steffen Pharai, Domenick Ansalone
  • Degradable cationic surfactants and use thereof in enhancing chemiluminescence
    Patent number: 10859504
    Abstract: The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: December 8, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • System and method for ECG data classification for use in facilitating diagnosis of cardiac rhythm disorders
    Patent number: 10849523
    Abstract: A system and method for ECG data classification for use in facilitating diagnosis of cardiac rhythm disorders is provided. ECG data is obtained via an electrocardiography monitor shaped for placement on a patient's chest. The ECG data is divided into segments and noise detection analysis is applied to the ECG data segments. A noise classification or a valid classification is assigned to each segment of the ECG data. At least one ECG data segment assigned the noise classification and that includes ECG data that corresponds with feedback from the patient via the electrocardiography monitor is identified. The ECG data that corresponds with the patient feedback is removed from the identified ECG data segment with the noise classification. The ECG data segments assigned the noise classification are removed from further analysis.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: December 1, 2020
    Assignee: Bardy Diagnostics, Inc.
    Inventors: Gust H. Bardy, Ezra M. Dreisbach
  • Heterogeneous membrane electrodes
    Patent number: 10852266
    Abstract: The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and inexpensive construction, preferably with only a single membrane coating on an electrode. The invented devices are potentiometric salt-bridge reference electrodes and dissolved gas sensors constructed with a heterogeneous membrane coating of a conductor. The heterogeneous membrane, which is an intimate admixture of a hydrophobic and a hydrophilic compartment, concurrently supports constrained transport of non-volatile species through its hydrophilic compartment and rapid gas and water vapor transport through its hydrophobic compartment.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Imants Lauks, Anca Varlan, Alexandra Oussova, Michael Bales
  • Method for internally coating a liquid test sample collection device with at least one anticoagulant compound, and devices and kits related thereto
    Patent number: 10850280
    Abstract: Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Reagents and methods for analysis of HIV
    Patent number: 10851428
    Abstract: The present invention is based in part on the present inventors' appreciation that certain sequences within an HIV genome are more likely to successfully detect HIV across a breadth of HIV variants. The ability to detect and/or quantify the presence and/or load of HIV in a subject is important to, among other things, the diagnosis and treatment of infected individuals. The present invention is based, in part, on the discovery of oligonucleotide reagents that detectably amplify sequences from a greater breadth of HIV samples than certain prior reagents and/or that generate amplicons from HIV genomes from which certain prior reagents would not have generated amplicons. Oligonucleotide reagents as described herein provide unexpected benefits in the detection and/or quantification of the presence and/or load of HIV in a subject, and thereby in the diagnosis and treatment of HIV.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Sunil Pandit, Arejas Uzgiris, Lance Palmer
  • DIAGNOSTIC ASSAY CARTRIDGE FOR CONDUCTING MULTIPLE DIAGNOSTIC ASSAYS ON A PATIENT'S SINGLE LIQUID TEST SAMPLE AND METHODS OF USE RELATED THERETO
    Publication number: 20200368746
    Abstract: Devices, kits, and methods for conducting a plurality of diagnostic assays on a patient's single liquid test sample within a single reaction cassette.
    Type: Application
    Filed: February 13, 2019
    Publication date: November 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • INSTRUMENT AND SYSTEM FOR RAPID MICROORGANISM IDENTIFICATION AND ANTIMICROBIAL AGENT SUSCEPTIBILITY TESTING
    Publication number: 20200370086
    Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.
    Type: Application
    Filed: February 28, 2020
    Publication date: November 26, 2020
    Applicant: Accelerate Diagnostics, Inc.
    Inventors: Austin Ashby, Wayne Showalter, Jasmin Cote
  • QUALITY CONTROL SUBSTANCES FOR USE WITH MICROSCOPY-BASED URINE SEDIMENT ANALYZERS AND METHODS OF USING THE SAME
    Publication number: 20200371086
    Abstract: Provided herein are quality control substances for use with a microscopy-based urine sediment analyzer. The quality control substances comprise a urine matrix and a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof. Methods of detecting the presence of an analyte in a urine sample from a subject, quality control substances for use in identifying the presence of one or more analytes in a urine sample from a subject, and the use of a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof in the manufacture of a quality control substance for use with a microscopy-based urine analyzer are also provided.
    Type: Application
    Filed: August 24, 2018
    Publication date: November 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Kausik Das
  • Cell-specific signaling biomarker analysis by high parameter cytometry; sample processing, assay set-up, method, analysis
    Patent number: 10845363
    Abstract: The present invention recognizes that current clinical laboratory testing methods for multiparametric single cell analysis are limited to analysis of intact live cells, and are insufficient for identification of signaling activation profile defining certain cell types, including but not limited to neoplastic and immunologically activated cell subsets. One aspect of the present invention generally relates to marker selection in panels to include proteins routinely assessed in standard FCM, while preferably also incorporating markers for surface receptor proteins within activated signaling cascades.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 24, 2020
    Assignee: DeePath Medical Diagnostics, Inc.
    Inventor: Jita De
  • Determination of copy number variations using binomial probability calculations
    Patent number: 10847250
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 24, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • SENSOR ARRAY
    Publication number: 20200363396
    Abstract: In the various illustrative embodiments herein, test devices are described with opposing sensor arrays and same side contacts.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 19, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jennifer A. Samproni, Todd Andrade, Marlene Shi
  • METHOD AND APPARATUS FOR PERFORMING BLOCK RETRIEVAL ON BLOCK TO BE PROCESSED OF URINE SEDIMENT IMAGE
    Publication number: 20200364591
    Abstract: The inventive concepts herein relate to performing block retrieval on a block to be processed of a urine sediment image. The method comprises: using a plurality of decision trees to perform block retrieval on the block to be processed, wherein each of the plurality of decision trees comprises a judgment node and a leaf node, and the judgment node judges the block to be processed to make it reach the leaf node by using a block retrieval feature in a block retrieval feature set to form a block retrieval result at the leaf node, and at least two decision trees in the plurality of decision trees are different in structures thereof and/or judgments performed by the judgment nodes thereof by using the block retrieval feature; and integrating the block retrieval results of the plurality of decision trees so as to form a final block retrieval result.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 19, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tian Shen, Juan Xu, Xiao Fan Zhang
  • Monitor mountable status light
    Patent number: 10838454
    Abstract: A monitor-mounted status indicator light assembly is disclosed, including at least one status indicator light and a mounting bracket adapted for mounting on a monitor. In some embodiments, standard VESA mounting configurations are employed, and the assembly's mounting bracket does not interfere with, or prevent, mounting of the monitor to a monitor mounting arm via the same VESA mounts.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 17, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Scott Salmon, Daniel LiCalzi, Daniel J. McDermott
  • Method for detecting total 25-hydroxyvitamin D using antibodies to 25-hydroxyvitamin D2 and D3
    Patent number: 10837973
    Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: November 17, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Niver Panosian Sahakian, Bruce A. Campbell, Spencer Hsiang-Hsi Lin, James Vincent Freeman, Qimu Liao, Ramon A. Evangelista
  • Linear motor housing construction
    Patent number: 10829316
    Abstract: A system for transporting a carrier vehicle using linear motors comprising a linear motor housing shaped to hold one or more linear motors includes a rectangular top plate. A left side plate is connected adjacent to a first longitudinal edge of the rectangular top plate and a right side plate is connected adjacent to a second longitudinal edge of the rectangular top plate. The linear motor housing further includes a plurality of coupling components operable to couple the linear motor housing to one or more adjacent linear motor housings in a manner that facilitates continuous propulsion of the carrier vehicle across the rectangular top plate of the linear motor housing and rectangular top plates corresponding to the one or more adjacent linear motor housings.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 10, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Ilya Malyarov
  • Removable cap with seal designed to be opened by piercing in a diagnostic analyzer
    Patent number: 10829278
    Abstract: Embodiments are directed to a removable cap with a conduction seal closure for sealing an opening of a container. The cap has a side wall and a top wall with an open access hole there-through. A flat upper portion surrounds the open access hole, which is sealed by the conduction seal. The conduction seal comprises a first polymer sealing layer, an aluminum foil layer on top of the first layer to heat seal the first layer to the cap, and a second polymer layer arranged on top of the aluminum foil layer for protection. The aluminum foil provides a formable shaping strength such that upon seal piercing, a permanent memory spread of the first and third layers is achieved. Removal of the cap does not damage the seal. Access to the container contents is achieved without probe contact to the as-pierced seal.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: November 10, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: James W. Kegelman, Joseph E. Brennan, William E. Hudson