Patents Assigned to Dipharma S.p.A.
  • Process for the preparation of tolterodine
    Patent number: 7335793
    Abstract: A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Pietro Allegrini
  • Process for the mononitration of alkanediols
    Patent number: 7335789
    Abstract: A process for the preparation of compounds of formula (I): HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi
  • Process for the preparation of clopidogrel
    Patent number: 7329751
    Abstract: A process for the preparation of clopidogrel (1) by reaction of the N,N?-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (R)-2-chlorophenylacetic acid derivatives of formula (13) in which X and R have the meanings as indicated in the disclosure.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: February 12, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Alberto Bologna
  • Process for the preparation of (?) modafinil
    Patent number: 7316918
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: January 8, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti
  • Process for the preparation of Imiquimod and intermediates thereof
    Patent number: 7301027
    Abstract: Novel intermediates useful for the preparation of Imiquimod and a process for the preparation of Imiquimod with the intermediates.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: November 27, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Lino Colombo, Enrico Mariotti, Pietro Allegrini, Graziano Castaldi
  • Process for the preparation of benzo [d] isoxazol-3-yl-methanesulfonic acid and the intermediates thereof
    Patent number: 7291742
    Abstract: A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 6, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Graziano Castaldi, Plietro Allegrini, Vittorio Lucchini, Alberto Bologna
  • Process for preparing terbinafine by using platinum as catalyst
    Patent number: 7288678
    Abstract: A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: October 30, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Antonio Tarquini, Graziano Castaldi, Gianluca Galdi, Pietro Allegrini
  • Ziprasidone Hydrochloride Polymorph and Process for Its Preparation
    Publication number: 20070225295
    Abstract: New crystalline form of ziprasidone hydrochloride hemihydrate, process for its preparation, its use for the purification of ziprasidone, its pharmaceutical compositions and their use in therapy.
    Type: Application
    Filed: May 10, 2005
    Publication date: September 27, 2007
    Applicants: DIPHARMA S.P.A., LUNDBECK PHARMACEUTICALS ITALY S.P.A.
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Graziano Castaldi
  • Intermediates for the preparation of pramipexole
    Publication number: 20070191439
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Application
    Filed: March 11, 2005
    Publication date: August 16, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini
  • Process for the preparation of ziprasidone
    Publication number: 20070117810
    Abstract: A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 24, 2007
    Applicants: DIPHARMA S. P. A., LUNDBECK PHARMACEUTICALS ITALY S. P. A.
    Inventors: Jacopo Zanon, Oscar Martini, Francesco Ciardella, Luca Gregori, Federico Sbrogio, Andrea Castellin
  • Protriptyline hydrochloride crystalline form
    Publication number: 20070112073
    Abstract: Protriptyline hydrochloride crystalline Form B, a process for its preparation, a pharmaceutical composition containing it the use thereof.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 17, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Gianpiero Ventimiglia, Domenico Magrone, Pietro Allegrini, Gabriele Razzetti
  • PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS
    Publication number: 20070093540
    Abstract: A process for the preparation of angiotensin II antagonists and novel intermediates useful for the synthesis thereof.
    Type: Application
    Filed: October 19, 2006
    Publication date: April 26, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro ALLEGRINI, Gabriele Razzetti, Roberto Rossi, Vittorio Lucchini, Simone Mantegazza, Marcello Rasparini
  • Process for the preparation of (-) modafinil
    Publication number: 20070087422
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 19, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti
  • Process for destructively scrubbing methyl chloride gas
    Publication number: 20070053819
    Abstract: A process for destructively scrubbing methyl chloride gas by the reaction with a sulfated organic compound.
    Type: Application
    Filed: September 5, 2006
    Publication date: March 8, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Gabriele Razzetti, Pietro Allegrini
  • Process for the preparation of cilostazol and of the intermediates thereof
    Publication number: 20070027325
    Abstract: A process for the preparation of compounds of formula (III), intermediates useful for the synthesis of cilostazol, which process comprises reacting haloimine of formula (V) wherein X is halogen, with trimethylsilyl azide.
    Type: Application
    Filed: July 29, 2004
    Publication date: February 1, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Andrea Beltrame, Graziano Castaldi
  • Process for the preparation of benzylimidazole derivatives
    Patent number: 7164029
    Abstract: A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: January 16, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Graziano Castaldi, Vittorio Lucchini
  • Process for the purification of imiquimod
    Publication number: 20070010675
    Abstract: Crystalline forms of imiquimod, a process for the preparation thereof and the use thereof in the purification of imiquimod.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 11, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Alberto Bologna, Domenico Magrone, Gianpiero Ventimiglia
  • Crystalline form of fosinopril calcium
    Publication number: 20060270633
    Abstract: Novel crystalline form of fosinopril calcium, process for its preparation, pharmaceutical compositions and use thereof in therapy.
    Type: Application
    Filed: May 23, 2006
    Publication date: November 30, 2006
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Gianpiero Ventimiglia
  • Process for the preparation of telmisartan
    Publication number: 20060264644
    Abstract: A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis.
    Type: Application
    Filed: May 2, 2006
    Publication date: November 23, 2006
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Marcello Rasparini, Gabriele Razzetti, Alberto Bologna, Giuseppe Barreca
  • Process for the preparation of tolterodine and intermediates thereof
    Patent number: 7119212
    Abstract: A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: October 10, 2006
    Assignee: Dipharma S.p.A.
    Inventors: Lino Colombo, Roberto Rossi, Pietro Allegrini, Graziano Castaldi