Patents Assigned to Dipharma S.p.A.
  • Process for the preparation of tolterodine
    Patent number: 7335793
    Abstract: A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Pietro Allegrini
  • Process for the preparation of clopidogrel
    Patent number: 7329751
    Abstract: A process for the preparation of clopidogrel (1) by reaction of the N,N?-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (R)-2-chlorophenylacetic acid derivatives of formula (13) in which X and R have the meanings as indicated in the disclosure.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: February 12, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Alberto Bologna
  • Process for the preparation of (?) modafinil
    Patent number: 7316918
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: January 8, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti
  • Process for the preparation of Imiquimod and intermediates thereof
    Patent number: 7301027
    Abstract: Novel intermediates useful for the preparation of Imiquimod and a process for the preparation of Imiquimod with the intermediates.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: November 27, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Lino Colombo, Enrico Mariotti, Pietro Allegrini, Graziano Castaldi
  • Process for the preparation of benzo [d] isoxazol-3-yl-methanesulfonic acid and the intermediates thereof
    Patent number: 7291742
    Abstract: A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 6, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Graziano Castaldi, Plietro Allegrini, Vittorio Lucchini, Alberto Bologna
  • Process for preparing terbinafine by using platinum as catalyst
    Patent number: 7288678
    Abstract: A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: October 30, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Antonio Tarquini, Graziano Castaldi, Gianluca Galdi, Pietro Allegrini
  • Ziprasidone Hydrochloride Polymorph and Process for Its Preparation
    Publication number: 20070225295
    Abstract: New crystalline form of ziprasidone hydrochloride hemihydrate, process for its preparation, its use for the purification of ziprasidone, its pharmaceutical compositions and their use in therapy.
    Type: Application
    Filed: May 10, 2005
    Publication date: September 27, 2007
    Applicants: DIPHARMA S.P.A., LUNDBECK PHARMACEUTICALS ITALY S.P.A.
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Graziano Castaldi
  • Intermediates for the preparation of pramipexole
    Publication number: 20070191439
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Application
    Filed: March 11, 2005
    Publication date: August 16, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini
  • Protriptyline hydrochloride crystalline form
    Publication number: 20070112073
    Abstract: Protriptyline hydrochloride crystalline Form B, a process for its preparation, a pharmaceutical composition containing it the use thereof.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 17, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Gianpiero Ventimiglia, Domenico Magrone, Pietro Allegrini, Gabriele Razzetti
  • PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS
    Publication number: 20070093540
    Abstract: A process for the preparation of angiotensin II antagonists and novel intermediates useful for the synthesis thereof.
    Type: Application
    Filed: October 19, 2006
    Publication date: April 26, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro ALLEGRINI, Gabriele Razzetti, Roberto Rossi, Vittorio Lucchini, Simone Mantegazza, Marcello Rasparini
  • Process for the preparation of (-) modafinil
    Publication number: 20070087422
    Abstract: An enzymatic process for the preparation of intermediates useful in the synthesis of (?) modafinil.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 19, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Sergio Riva, Paola Fassi, Pietro Allegrini, Gabriele Razzetti
  • Process for destructively scrubbing methyl chloride gas
    Publication number: 20070053819
    Abstract: A process for destructively scrubbing methyl chloride gas by the reaction with a sulfated organic compound.
    Type: Application
    Filed: September 5, 2006
    Publication date: March 8, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Gabriele Razzetti, Pietro Allegrini
  • Process for the preparation of cilostazol and of the intermediates thereof
    Publication number: 20070027325
    Abstract: A process for the preparation of compounds of formula (III), intermediates useful for the synthesis of cilostazol, which process comprises reacting haloimine of formula (V) wherein X is halogen, with trimethylsilyl azide.
    Type: Application
    Filed: July 29, 2004
    Publication date: February 1, 2007
    Applicant: DIPHARMA S.P.A.
    Inventors: Andrea Beltrame, Graziano Castaldi
  • Process for the preparation of benzylimidazole derivatives
    Patent number: 7164029
    Abstract: A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: January 16, 2007
    Assignee: Dipharma S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Graziano Castaldi, Vittorio Lucchini
  • Process for the purification of imiquimod
    Publication number: 20070010675
    Abstract: Crystalline forms of imiquimod, a process for the preparation thereof and the use thereof in the purification of imiquimod.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 11, 2007
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Alberto Bologna, Domenico Magrone, Gianpiero Ventimiglia
  • Crystalline form of fosinopril calcium
    Publication number: 20060270633
    Abstract: Novel crystalline form of fosinopril calcium, process for its preparation, pharmaceutical compositions and use thereof in therapy.
    Type: Application
    Filed: May 23, 2006
    Publication date: November 30, 2006
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Gianpiero Ventimiglia
  • Process for the preparation of telmisartan
    Publication number: 20060264644
    Abstract: A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis.
    Type: Application
    Filed: May 2, 2006
    Publication date: November 23, 2006
    Applicant: DIPHARMA S.p.A.
    Inventors: Pietro Allegrini, Marcello Rasparini, Gabriele Razzetti, Alberto Bologna, Giuseppe Barreca
  • Process for the preparation of tolterodine and intermediates thereof
    Patent number: 7119212
    Abstract: A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: October 10, 2006
    Assignee: Dipharma S.p.A.
    Inventors: Lino Colombo, Roberto Rossi, Pietro Allegrini, Graziano Castaldi
  • Process for the preparation of tolterodine
    Publication number: 20060189827
    Abstract: A novel process for the preparation of tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.
    Type: Application
    Filed: February 21, 2006
    Publication date: August 24, 2006
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Pietro Allegrini
  • Process for the preparation of pantoprazole and salts thereof
    Patent number: 7081534
    Abstract: A process for the preparation of pantoprazole and the salts thereof, comprising the reaction of a mercaptoimidazole with a picoline, to give a 2-pyridinyl-methylsulfinyl-2-benzimidazole intermediate, the oxidation thereof with ?-phthalimidoperhexanoic acid and the subsequent methoxylation.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: July 25, 2006
    Assignee: Dipharma S.p.A.
    Inventors: Caterina Napoletano, Eleonora Porta, Pietro Allegrini, Graziano Castaldi