Patents Assigned to Dipharma S.p.A.
  • Process for the preparation of benzo [d] isoxazol-3-yl-methanesulfonic acid and the intermediates thereof
    Publication number: 20060135582
    Abstract: A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid of formula (I), or a salt thereof, and the intermediates thereof, useful as an intermediate in the preparation of zonisamide.
    Type: Application
    Filed: December 24, 2003
    Publication date: June 22, 2006
    Applicant: Dipharma S.P.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Graziano Castaldi, Pietro Allegrini, Vittorio Lucchini, Alberto Bologna
  • Crystalline form of rabeprazole sodium
    Publication number: 20060135565
    Abstract: Rabeprazole sodium in crystalline hydrate forms, a pharmaceutical composition containing them, their use in therapy, a process for their preparation, and the use thereof for the purification of rabeprazole sodium.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 22, 2006
    Applicant: DIPHARMA S.P.A.
    Inventors: Luciana Malpezzi, Tommaso Giovenzana, Pietro Allegrini, Gianpiero Ventimiglia
  • Process for the preparation of pantoprazole and intermediates therefor
    Patent number: 7060839
    Abstract: A novel process is described for the preparation of the active principle pantoprazole based on the use of novel intermediate compounds of general formula (I) where X is an atom of halogen and n=0 or 1, so that when n=1, the intermediate compounds are methoxylated, and when n=0 said intermediate compounds are first oxidized to n=1 and thereafter are methoxylated. Also described are the novel intermediates, as well as the process for the preparation thereof.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: June 13, 2006
    Assignee: Dinamite Dipharma (Dipharma S.P.A.)
    Inventors: Pilar Sturla De Palomo, legal representative, Deborah Palomo Sturla, legal representative, Alberto Palomo Sturla, legal representative, Alberto Palomo Coll, deceased
  • Process for the preparation of modafinil
    Patent number: 7057068
    Abstract: A process for the preparation of 2-[(diphenylmethyl)sulfinyl]acetamide (I) comprising the oxidation of sodium 2-[(diphenylmethyl)sulfenyl]acetate to the corresponding sulfoxide and the derivatization of the latter to amide
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: June 6, 2006
    Assignee: DIPHARMA S.p.A.
    Inventors: Graziano Castaldi, Vittorio Lucchini, Antonio Tarquini
  • Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group
    Patent number: 6998490
    Abstract: A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ?-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: February 14, 2006
    Assignees: Dinamite Dipharma S.p.A., Abbreviated Dipharma S.p.A.
    Inventors: Pietro Allegrini, Caterina Napoletano, Gabriele Razzetti, Graziano Castaldi
  • Fexofenadine base polymorphic forms
    Publication number: 20060025444
    Abstract: The invention relates to novel crystalline forms of fexofenadine base, a process for the preparation thereof and the use thereof in therapy.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 2, 2006
    Applicant: DIPHARMA S.P.A.
    Inventors: Gianpiero Ventimiglia, Pietro Allegrini, Graziano Castaldi
  • Process for the preparation of benazepril hydrochloride
    Patent number: 6979736
    Abstract: A process for the preparation of benazepril hydrochloride (2) starting from the Michael adduct (14), obtained reacting compounds of formula (11) and (13), as defined in the disclosure
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: December 27, 2005
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Gabriele Razzetti, Simone Mantegazza
  • Fexofenadine polymorphs and process for the preparation thereof
    Publication number: 20050282860
    Abstract: The invention provides novel crystalline forms of fexofenadine hydrochloride, a process for the preparation of the novel forms and of the known form A, and their use in therapy.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 22, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Pietro Allegrini, Gianpiero Ventimiglia
  • Process for the preparation of keto compounds
    Publication number: 20050277775
    Abstract: A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-?,?-dimethylbenzeneacetic acid, useful as an intermediate in the preparation of fexofenadine.
    Type: Application
    Filed: June 14, 2005
    Publication date: December 15, 2005
    Applicant: DIPHARMA S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Antonio Tarquini
  • Process for the preparation of tolterodine and intermediates thereof
    Publication number: 20050222437
    Abstract: A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 6, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Lino Colombo, Roberto Rossi, Pietro Allegrini, Graziano Castaldi
  • Process for the preparation of benazepril hydrochloride
    Publication number: 20050203294
    Abstract: A process for the preparation of benazepril hydrochloride (2) starting from the Michael adduct (14), obtained reacting compounds of formula (11) and (13), as defined in the disclosure.
    Type: Application
    Filed: April 25, 2003
    Publication date: September 15, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Gabriele Razzetti, Simone Mantegazza
  • Process for the preparation of clopidogrel
    Publication number: 20050143414
    Abstract: A process for the preparation of clopidogrel (1) by reaction of the N,N?-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (R)-2-chlorophenylacetic acid derivatives of formula (13) in which X and R have the meanings as indicated in the disclosure.
    Type: Application
    Filed: April 22, 2003
    Publication date: June 30, 2005
    Applicant: Dipharma S.P.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Alberto Bologna
  • Process for the preparation of valsartan and intermediates thereof
    Publication number: 20050131038
    Abstract: A novel process for the preparation of valsartan and novel intermediates useful in the preparation thereof.
    Type: Application
    Filed: November 19, 2004
    Publication date: June 16, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Giancarlo Verardo, Paola Geatti, Graziano Castaldi, Nicoletta Toniutti, Pietro Allegrini
  • Process for the preparation of crystalline losartan potassium
    Publication number: 20050131040
    Abstract: A process for the preparation of crystalline losartan potassium and crystalline hydrate losartan potassium.
    Type: Application
    Filed: December 14, 2004
    Publication date: June 16, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli, Pietro Allegrini, Graziano Castaldi
  • Phenyltetrazole compounds
    Publication number: 20050119488
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Application
    Filed: November 24, 2004
    Publication date: June 2, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli
  • Process for the preparation of benzylimidazole derivatives
    Publication number: 20050090672
    Abstract: A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan.
    Type: Application
    Filed: October 21, 2004
    Publication date: April 28, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Pietro Allegrini, Gabriele Razzetti, Graziano Castaldi, Vittorio Lucchini
  • Process for the preparation of 4-[1-hydroxy -4-[4-(hydroxydiphenylmethly)-1-piperidinyl]-butyl]-&agr;, &agr;-dimethylbenzeneacetic acid
    Patent number: 6815549
    Abstract: A process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-&agr;,&agr;-dimethylbenzeneacetic acid (Fexofenadine) of formula
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: November 9, 2004
    Assignee: Dinamite Dipharma S.p.A.
    Inventors: Graziano Castaldi, Giuseppe Barreca, Domenico Magrone
  • Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group
    Publication number: 20040192929
    Abstract: A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of &egr;-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.
    Type: Application
    Filed: March 17, 2004
    Publication date: September 30, 2004
    Applicant: DINAMITE DIPHARMA S.P.A. abbreviated DIPHARMA S.P.A.
    Inventors: Pietro Allegrini, Caterina Napoletano, Gabriele Razzetti, Graziano Castaldi
  • Clopidogrel salts with alkyl-sulphuric acids
    Publication number: 20040132765
    Abstract: Clopidogrel salts with alkyl-sulphuric acids, having the following formula (I) 1
    Type: Application
    Filed: October 17, 2003
    Publication date: July 8, 2004
    Applicants: DINAMITE DIPHARMA S.P.A., ABBREVIATED DIPHARMA S.P.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Domenico Magrone
  • Process for the preparation of high purity Pemirolast
    Patent number: 6703505
    Abstract: A novel process for the purification of Pemirolast, whose potassium salt is an anti-allergic pharmaceutical product, is disclosed.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: March 9, 2004
    Assignee: Dinamite Dipharma S.p.A.
    Inventors: Graziano Castaldi, Erminio Oldani