Abstract: Voriconazole is prepared by a process comprising condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to give (2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-diflurophenyl)-1-(1H -1,2,4-triazole-1-yl)butan-2-ol.
Type:
Grant
Filed:
June 10, 2010
Date of Patent:
October 18, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: Pharmaceutical compositions comprising a plurality of formulated particles containing at least one active ingredient and at least one pharmaceutically acceptable excipient, granulated with a granulating composition containing at least one pharmaceutical excipient.
Type:
Application
Filed:
June 10, 2011
Publication date:
September 29, 2011
Applicants:
DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
Abstract: The present invention relates to processes for the preparation of rasagiline mesylate. Also provided is rasagiline mesylate having 90 volume percent of the particles (D90) with sizes less than about 6 ?m and processes for the preparation thereof.
Type:
Application
Filed:
May 20, 2011
Publication date:
September 8, 2011
Applicants:
DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
Abstract: There are provided processes for making rivastigmine. In one embodiment, the process includes reacting S-(?)-[1-(3-hydroxyphenyl)ethyl]dimethylamine with N-ethyl-N-methyl carbamoyl chloride in the presence of an organic base to obtain a free base of rivastigmine.
Type:
Grant
Filed:
April 10, 2008
Date of Patent:
September 6, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: Processes for preparing azacitidine. Further included are processes for the preparation of crystalline azacitidine crystalline Form (I) and mixtures of azacitidine crystalline Forms (I) and (II).
Type:
Application
Filed:
January 28, 2011
Publication date:
August 18, 2011
Applicants:
DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
Abstract: Pharmaceutical compositions comprising bortezomib for oral or parenteral administration. Specific aspects relate to stable, sugar free pharmaceutical compositions of bortezomib, including its pharmaceutically acceptable salts or solvates, in the form of ready-to-use solutions, lyophilized forms, or physical admixtures, and the preparation thereof. Other aspects include processes for preparing compositions and methods of using compositions for treating various types of cancers in mammals.
Type:
Application
Filed:
March 31, 2011
Publication date:
July 21, 2011
Applicants:
DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
Abstract: There is provided a powder composition for use in a pharmaceutical product, the composition including a) 5(S)-(2?-hydroxyethoxy)-20(S)-CPT; at least one cyclodextrin; wherein 5(S)-(2?-hydroxyethoxy)-20(S)-CPT includes less than 5% of 5(R)-(2?-hydroxyethoxy)-20(S)-CPT. Preferably, in the powder composition, 5(S)-(2?-hydroxyethoxy)-20(S)-CPT is substantially free from said 5(R)-(2?-hydroxyethoxy)-20(S)-CPT.
Type:
Application
Filed:
May 27, 2008
Publication date:
July 21, 2011
Applicants:
DR. REDDY'S LABORATORIES LIMITED, DR. REDDY'S LABORATORIES, INC.
Abstract: Pharmaceutical formulations comprising raloxifene or its salts, esters, polymorphs, isomers, hydrates, solvates, or derivatives thereof having defined particle sizes. Also described are processes for preparing formulations and methods of using such formulations.
Type:
Application
Filed:
April 2, 2009
Publication date:
June 30, 2011
Applicants:
DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
Abstract: In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds. wherein R1 is selected from optionally substituted alkyl.
Type:
Grant
Filed:
September 8, 2008
Date of Patent:
May 10, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: The invention concerns an enantiomerically enriched compound of formula (1) or the opposite enantiomer thereof wherein each of Ar1—Ar4 represent the same or different aromatic groups of up to 20 carbon atoms and the bridging group X is the formula (5) in which * denotes points of attachment to phosphorus atoms and methods of making thereof.
Type:
Grant
Filed:
April 18, 2007
Date of Patent:
May 3, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
Philip M. Jackson, Ian Campbell Lennon, Martin E. Fox