Abstract: A valve comprises a shell, a flexible valve member sealingly mounted within the shell, and a valve body mounted atop the flexible valve member within the shell. The flexible member is moveable between closed and open positions to allow the flow of fluid therethrough. The valve is engageable with a filling device having flow ports and a surrounding closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). Alternatively, the valve may comprise a portion of a female connector and the filling device may comprise a portion of a male connector to form an aseptic fluid connector for the aseptic transfer of fluid therethrough.

Abstract: The invention relates to a bar winding arrangement of a stator or a rotor of an electric machine, including a number of bar segments, which are housed in a plurality of slots of the stator or the rotor and are electrically connected to one another in such a way that they form a continuous winding of the stator or the rotor, wherein each of the slots is divided by the bar segments into a first group of bar segments and at least one second group of bar segments, wherein the bar segments of the first group have a smaller cross section than the bar segments of the second group, wherein the bar segments of the first group are electrically connected in series and the bar segments of the second group are electrically connected in series and in parallel with the bar segments of the first group and wherein the bar segments of the first group are arranged closer to a slot opening in the radial direction than the bar segments of the second group.

Abstract: A rotating electrical machine includes a rotor iron, a stator iron and conductor bars. An air gap separates the rotor iron from the stator iron. The stator iron has a slot and the conductor bars run in the slot. The conductor bars have a first profile in a first segment, the conductor bars have a second profile in a second segment and the first profile differs from the second profile. Also described is a method which is adapted for producing an electrical machine.

Abstract: A method for producing a conductor segment includes: passing a copper bar in a predetermined direction of movement through a rotating first work roll and a second work roll rotating in the opposite direction to the first work roll; rotating a first backup roll in the opposite direction to the first work roll to brace the first work roll against the copper bar with an adjustable first force directed perpendicularly to the direction of movement; rotating at least one second backup roll in the opposite direction to the second work roll to brace the second work roll against the copper bar with an adjustable second force directed counter to the first force; and adjusting the first and second forces such that the work rolls give the conductor bar a thickness that varies along its length. Also described is a corresponding device and a corresponding method for producing an electric machine.

Abstract: A positioning apparatus for positioning a tubular fluid container in an elongate carrier which is configured as a hollow profile. In order to simplify the positioning of the tubular fluid container, the positioning apparatus includes spring elements, by way of which the tubular fluid container is positioned in the elongate carrier.

Abstract: Provided is a method of refolding of recombinant GCSF that minimizes the generation of oxidized forms of GCSF by optimizing the refolding of inclusion bodies containing recombinant GCSF.

Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Abstract: The present disclosure relates to SMD mounting. The teachings thereof may be embodied in heating elements having a mounting side for SMD mounting, the mounting side being available for placing onto a substrate, for example in the form of a circuit carrier, electronic assemblies with a circuit carrier and a component, and/or methods for producing an electronic assembly having a circuit carrier and a component placed on the circuit carrier. For example, a heating element may include: a mounting side for SMD mounting; a housing enclosing a cavity; and a reactive substance in the cavity that reacts exothermically at a reaction temperature T1.

Abstract: Crystalline Forms R5, R5a, R5b and R6 of nilotinib hydrochloride and processes for their preparation.

Abstract: A method controls an internal combustion engine that has a drive output shaft connected to an input shaft of a transmission. The internal combustion engine, the transmission and a drive wheel are encompassed by a drivetrain for the drive of a motor vehicle. The method includes determining a rotational acceleration of the input shaft and determining an input torque at the input shaft of the transmission based on a product of the rotational acceleration and a speed reduction ratio-dependent moment of inertia of the drivetrain in a section between the input shaft and the drive wheel. A combustion torque of the internal combustion engine is controlled such that the input torque adheres to a predetermined maximum input torque at the input shaft of the transmission.

Abstract: An apparatus for adjusting the length of connecting rods in an internal combustion engine, having a shift guide plate arrangement which has shift guide plates which can be adjusted in one spatial direction for actuating connecting rod actuating devices which are integrated into the connecting rods for the purpose of changing the length of the respective connecting rod. The shift guide plates are connected fixedly to a carrier frame. The carrier frame is mounted in a stationary oil scraper arrangement such that it can be displaced in the spatial direction. The oil scraper arrangement has oil scrapers for stripping oil from the connecting rods.

Abstract: A traction control method and device for a vehicle is disclosed. In the method, an actual slip of a wheel of the vehicle is made available, a filtered actual slip is determined adaptively from the actual slip by an adaptive filter, the filtered actual slip is passed on to a controller, and the engine torque is set by the controller as a function of the filtered actual slip and of a target slip.

Abstract: A shifting gate arrangement, and a method of production thereof, having shifting gates, which are adjustable in a spatial direction, for actuating connecting rod adjustment provisions, which are integrated in connecting rods, for the purpose of changing the length of the respective connecting rod. A sheet metal support frame is mounted so as to be displaceable to and fro in the one spatial direction. The shifting gates are fixedly connected to the support frame and are designed as a cast part or sintered part.

Abstract: A connecting rod has a big end bearing eye for attachment to a crankshaft, a small end bearing eye for attachment to a piston of a cylinder, and an eccentric adjusting device for adjusting an effective connecting rod length. The eccentric adjusting device has eccentric rods (15, 16) with first ends that engage on an eccentric lever of the eccentric adjusting device and second ends that engage on pistons (20, 21) guided in hydraulic chambers of the connecting rod. The second ends of the eccentric rods (15, 16) are spherical heads that engage in a corresponding recess (40) in the respective piston (20, 21), and the respective piston (20, 21) further accommodates a retention element (41), one segment of which rests on the spherical-headed end of the respective eccentric rods (15, 16).

Abstract: A particulate filter for a motor vehicle has a casing (2) that allows through flow. A core (4) is accommodated in the casing (2) and allows through flow. The casing (2) has a longitudinal axis (3). A through flow duct (9) is formed between the casing (2) and the core (4) to allow the through flow of exhaust gas from an internal combustion engine of the motor vehicle. A ring (7) is arranged in the through flow duct (9) and gives the through flow duct (9) a labyrinth-type configuration.

Abstract: An internal combustion engine with an adjustable compression ratio has connecting rods (1), each of which has a hydraulically adjustable eccentric adjustment device arranged in a connecting rod bearing eye (2) and/or in a crankpin bearing eye (3) for adjusting an effective connecting rod length (leff) of the respective connecting rod (1). Travel of the eccentric adjustment device is controlled by a switchover valve (10). Each switchover valve (10) has a pick-off means (14). The switchover valves (10) can be actuated by an actuation device (15) that has a switching fork (16) for each switchover valve (10) and thus for each pick-off means (14) to be actuated. The pick-off means (14) and the switching forks (16) are oriented relative to one another so that inertial forces acting during driving assist the actuation of the switchover valves (10) by the actuation device (15).

Abstract: The invention provides a pharmaceutical composition for intranasal administration comprising a salt of sumatriptan or a physiologically acceptable solvate thereof, an alkyl glycoside or saccharide alkyl ester and optionally at least one pharmaceutically acceptable excipient, wherein the said composition provides Tmax value of less than 30 minutes upon said administration. Other aspects and embodiments are contemplated and described. The invention also provides a pharmaceutical composition for intranasal administration comprising a triptan, a pharmaceutically acceptable vehicle and a mucosal permeation enhancer, wherein upon said administration said composition provides a Tmax substantially equivalent to subcutaneous administration of said triptan. Other aspects and embodiments are contemplated and described.

Abstract: The invention discloses a three-dimensional complementary-conducting-strip (CCS) structure. Some two-dimensional mesh metal layers are stacked vertically and connected mutually via numerous vias to form a three-dimensional network structure, and one or more signal lines with three-dimensional trace style(s) are positioned inside and separated away the three-dimensional network structure. Moreover, each two-dimensional mesh metal layer is a planar metal layer with one or more empty areas. The three-dimensional network structure is grounded, the signal lines(s) is electrically connected to the device(s) and/or terminal(s) respectively, and the dielectric material(s) is used to electrically insulate the signal line(s) from the three-dimensional network structure.

Abstract: A vehicle, in particular an electric vehicle or a hybrid vehicle, having a charging apparatus for charging a vehicle-integrated energy storage cell by means of an external voltage source, wherein the charging apparatus has a charge pump for setting a voltage ratio between an input voltage and an output voltage, wherein the charge pump provides at east two discrete voltage ratios.

Abstract: A cooling device for a vehicle, having an inner housing with an inner cooling wall, and an outer housing which surrounds the inner housing, is spaced apart via a cooling gap and has an outer cooling wall. A cooling volume for passage of a cooling fluid is formed between the inner cooling wall and the outer cooling wall. The inner cooling wall and/or the outer cooling wall furthermore have channel walls for dividing the cooling volume and guiding the cooling fluid. At least one clamping device is arranged around the circumference of a circumferential wall of the outer housing for introducing a deformation force into the outer housing in order to reduce the cooling gap by deforming the outer housing.