Abstract: One aspect of the invention provides a device for detecting an analyte in a sample. The device includes: a sample loading region, an imaging window, a well, and an absorbent pad. The sample loading region is in fluid communication with the well. The well is in fluid communication with the absorbent pad, such that when a fluid sample comprising solid support structures and a liquid carrier are applied to the sample loading region, the fluid sample travels to the well and at least part of the liquid carrier is absorbed into the absorbent pad.

Abstract: Composite Right/Left Handed (CRLH) Leaky-Wave Antennas (LWAs) are a class of radiating elements characterized by an electronically steerable radiation pattern. The design is comprised of a cascade of CRLH unit-cells populated with varactor diodes. By varying the voltage across the varactor diodes, the antenna can steer its directional beam from broadside to backward and forward end-fire directions. A CRLH Leaky-Wave Antenna for the 2.4 GHz Wi-Fi band is miniaturized by etching a Complementary Split-Ring Resonator (CSRR) underneath each CRLH unit-cell. As opposed to conventional LWA designs, the LWA layout does not require thin interdigital capacitors, significantly reducing the PCB manufacturing constraints required to achieve size reduction. The resulting antenna enables CRLH LWAs to be used not only for wireless access points, but also potentially for mobile devices.

Abstract: A multi-site probe for interfacing with the central nervous system includes one more structures disposed perpendicularly on a backing layer, where each structure includes a braided sleeve over a flexible or rigid core, and a delivery-vehicle. The structures may include optrodes and electrodes. The location of the probe may be determined through the application of combinatorics.

Abstract: The present invention provides a method of incorporating a gaseous hydrocarbon into a liquid hydrocarbon. The method comprises steps of exposing a gaseous hydrocarbon to non-thermal plasma generated using a reduced electric field with an E/N ratio in a range of from about 10 to about 30 Td to activate the gaseous hydrocarbon, and contacting the activated gaseous hydrocarbon with the liquid hydrocarbon to incorporate the gaseous hydrocarbon into the liquid hydrocarbon. The method provides the advantages of low energy consumption and relatively low capital expenditure.

Abstract: The framework herein may be called outcome-based ventilation (OBV) for evaluating ventilation rates (VR) in commercial buildings and using a system to make informed control decisions based on the resultant indoor air quality (IAQ) and energy consumption outcomes.

Abstract: An impact fatigue device includes a striker rod assembly configured to reciprocally move between an upstream position and a downstream position. The striker rod assembly includes a striker rod slidingly mounted on a support member and a trigger located upstream of the striker rod and adapted to move downstream to engage the striker rod and propel the striker rod downstream. An actuator assembly is located upstream of the striker rod assembly. The actuator assembly is configured to releasably engage the trigger and to translate the trigger upstream. A reset mechanism is configured to releasably engage the striker rod and to move the striker rod from the downstream position to the upstream position. A method of operating the impact fatigue device is also disclosed.

Abstract: Anhydrosugar-based monomers prepared from isosorbide, isomannide, and isoidide and resin systems containing these anhydrosugar-based monomers that are partially to fully bio-based, which may produce materials having properties that meet or exceed the properties of similar petroleum derived vinyl ester resins.

Abstract: A wearable power harvesting system includes a knitted fabric rectenna including an antenna adapted to receive radio-frequency energy within a desired frequency band and a rectifier circuit that converts received radio-frequency energy into a DC current and voltage. A knitted fabric load/storage unit stores DC power from the rectifier circuit. The power harvesting system is adapted to harvest the radio-frequency energy within the desired frequency band, which may include WLAN frequencies such as the standard 2.4 GHz and 5 GHz WLAN standard frequencies.

Abstract: One aspect of the invention provides a method for multi-nozzle biopolymer deposition of heterogeneous materials to create or modify a composite biopolymer multi-part three-dimensional assembly having at least one biomimetic and at least one non-biomimetic feature. The method includes: (a) utilizing a CAD environment to design and/or modify a composite multi-part assembly, thereby producing a CAD design; (b) converting the CAD design into a three-dimensional heterogeneous material and multi-part assembly model in a format suitable for three-dimensional, multi-nozzle printing, wherein the design comprises at least one biomimetic feature and at least one non-biomimetic feature; and (c) printing the composite assembly by simultaneously depositing the heterogeneous materials using multiple, different, specialized nozzles, wherein the simultaneous depositing includes direct deposition of cells.

Abstract: An aqueous approach to synthesize capped SnS quantum dots (QDs) followed by optional capping molecule extension by attaching one or more extending molecules to the capping molecule via peptide bond formation at elevated temperature. The capped SnS QDs may have a capping molecule:Sn:S molar ratio of 16:3:1 to 16:12:1. A suspension of SnS QDs was heat-treated at 200° C. for 0.5-4 hrs. The obtained SnS QDs showed an NIR emission peak at 820-835 nm with an excitation wavelength at 690 nm. The as synthesized SnS QDs were found to have high positive zeta potential of ˜30 mV and thus were toxic to cells. By neutralizing the SnS QDs the cytotoxicity was reduced to an accepted level. The heat-treatment step can be obviated by adding a glycerol solution containing S2? anions and capping molecule to a glycerol solution of Sn2+ ions.

Abstract: Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia. The effect of artifacts (e.g., strong surgery room lighting, patient-table tilting, patient intubation/extubation) on the fNIR signal may be removed using a noise removal algorithm. In selecting the noise removal algorithm, a switching technique may be used to select the component analysis algorithm, such as a principal component analysis (PCA), an independent component analysis (ICA), or the like.

Abstract: Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over computing environments using fNIR brain computer interfaces. Further still, a scale for brain interface index for oxygenation of a portion of the brain is provided herein.

Abstract: A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. The PEFS may be incorporated into a portable hand-held device. The PEFS offers superior sensitivity.

Abstract: A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.

Abstract: The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.

Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.

Abstract: A prosthetic ankle comprising a talar component and a tibial component. At least a portion of top surface of the talar component has a convex curvature, relative to a location above the top surface, in the anterior to posterior direction as viewed in a sagittal plane cross-section, a concave curvature relative to a location above the top surface, in the medial to lateral direction, and an average radius of curvature of at least a major portion of the medial side of the top surface of the talar component is larger than an average radius of curvature of at least a major portion of the lateral side of the top surface of the talar component as viewed in sagittal plane cross-sections on the lateral and medial sides. A bearing component for location between the tibial and talar component is also described.

Abstract: A method for selecting the state of a reconfigurable antenna installed at either the receiver or transmitter of a communication system is provided. The proposed method uses online learning algorithm based on the theory of multi-armed bandit to perform antenna state selection. The selection technique utilizes the Post-Processing Signal-to-Noise Ratio (PPSNR) as a reward metric and maximizes the long-term average reward over time. The performance of the learning based selection technique is empirically evaluated using wireless channel data. The data is collected in an indoor environment using a 2×2 MIMO OFDM system employing highly directional metamaterial Reconfigurable Leaky Wave Antennas. The learning based selection technique shows performance improvements in terms of average PPSNR and regret over conventional heuristic policies.

Abstract: A total artificial heart for a mammalian cardiovascular system is provided. The total artificial heart has a pump casing including an outer housing and an integral hollow support shaft extending therethrough. The casing defines a first flow path within the outer housing about an exterior of the hollow support shaft and a separate second flow path extending within the hollow support shaft. An annular impeller is housed within the outer housing of the casing for rotation about the hollow support shaft to provide a centrifugal flow pump in the first flow path, and an axial flow impeller is housed within the hollow support shaft of the casing for forming an axial flow pump in the second flow path.

Abstract: The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In certain embodiments, the subject is further administered at least one additional therapeutic agent.