Abstract: Pharmaceutical compositions comprising a RelA enzyme inhibitor and a bactericidal antibiotic, wherein said RelA enzyme inhibitor binds to the RelA enzyme in bacteria to reduce biofilm formation and to degrade biofilms that have been formed. The pharmaceutical compositions can be used to treat bacterial biofilm diseases.

Abstract: A hydroponic growing system includes a base member, an upper tray removably inserted into the base member, and a lid portion removably attachable to the base member. The lid portion comprises a funnel extending from a top end of the lid toward a bottom end of the lid and a sidewall having a plurality of openings formed therein.

Abstract: Low phase noise signal generated in a small structure is required for communication and high-resolution imaging. A DBR based multi-mode laser is combined with mode-locking method to build frequency stabilized and tunable RF signal generator. The number of the output modes from each laser is adjusted using reflecting bandwidth of distributed Bragg reflector and electro-absorption (EA) modulator for amplitude control, while the phase section in integrated laser system provides frequency tuning. Mode-locking of 60 laser modes results in a highly frequency stable 10 GHz RF beat-notes with a calculated phase noise of ?150 dBc/Hz at 10 kHz offset frequency.

Abstract: The present disclosure is directed to methods for scrubbing low levels of urea from aqueous solutions such as a dialysate from dialysis, and including blood and blood products, and devices capable of employing these methods.

Abstract: The present disclosure is directed to using MXene compositions as templates for the deposition of oriented perovskite films, and compositions derived from such methods. Certain specific embodiments include methods preparing an oriented perovskite, perovskite-type, or perovskite-like film, the methods comprising: (a) depositing at least one perovskite, perovskite-type, or perovskite-like composition or precursor composition using chemical vapor deposition (CVD), physical vapor deposition (PVD), or atomic layer deposition (ALD) onto a film or layer of a MXene composition supported on a substrate to form a layered composition or precursor composition; and either (b) (1) heat treating or annealing the layered precursor composition to form a layered perovskite-type structure comprising at least one oriented perovskite, perovskite-type, or perovskite-like composition; or (2) annealing the layered composition; or (3) both (1) and (2).

Abstract: A device and method of thixotropic mixing and 3D printing of alloys is provided. The method includes the steps of locating a thixotropic mixer having a discharge nozzle above a substrate; adding a molten alloy to the mixer; locating the nozzle between about 1 mm and about 20 mm from the substrate; and extruding the alloy from the nozzle onto the substrate.

Abstract: In this paper, a novel field-programmable analog array (FPAA) is proposed to secure the intellectual property (IP) of analog and mixed-signal circuits. A obfuscation technique is developed to efficiently mask the topology of both differential mode and single-ended mode analog circuits.

Abstract: An alignment guide for total ankle replacement surgery and a method of creating and using the alignment guide. The alignment guide has a surface that interfaces with a corresponding surface of a superior aspect a talus of a patient, and as second surface portion that interfaces with a corresponding distal surface of a section of a tibia of the patient. When the alignment guide is in position, it maintains the ankle of the patient in a preselected position.

Abstract: A simulation-based optimization framework determines the sizing of components of an analog circuit to meet target design specifications while also satisfying the robustness specifications set by the designer. The robustness is guaranteed by setting a limit on the standard deviations of the variations in the performance parameters of a circuit across all process and temperature corners of interest Classifier chains are used that, in addition to modeling the relationship between inputs and outputs, learn the relationships among output labels. Additional design knowledge is inferred from the optimal ordering of the classifier chain.

Abstract: A method of detecting the length of an individual telomere is provided. In one embodiment, the method includes contacting genomic DNA with a guide RNA having a portion complementary to a telomere repeat sequence in the genomic DNA and with Cas9 nickase to produce a single-strand break in the genomic DNA at the telomere repeat sequence. The nicked DNA is contacted with a polymerase and fluorescently labeled nucleotide, wherein the fluorescently labeled nucleotide is incorporated into the nicked DNA at the telomere repeat sequence. The genomic DNA is contacted with a second nicking endonuclease which is specific for a sequence motif in the genomic DNA thereby producing a second nick in the genomic DNA at the motif sequence. The nicked DNA is contacted with a polymerase and second fluorescently labeled nucleotide of different color, wherein the second fluorescently labeled nucleotide is incorporated into the nicked DNA at the motif sequence location.

Abstract: A method for modeling textile structures using bicontinuous surfaces includes selecting a virtual scaffold of bicontinuous surfaces defining textile fabrication pathways to model spatial relationships between the pathways and yarns in a desired yarn pattern of a textile fabric design. The method further includes constructing a yarn pathway across the bicontinuous surfaces that form the virtual scaffold. The method further includes removing or releasing tension from the virtual scaffold, thereby allowing yarns to relax and determining a physical property of the textile fabric design.

Abstract: A garment includes a supercapacitor and/or heated fabrics including a first conductive yarn knitted to as to form a current collector and a second conductive yarn knitted to as to form an electrode that is in electrical contact with the current collector. The conductive yarns are knitted into a predetermined supercapacitor design having respective electrodes that are not in electrical contact with each other. An electrolyte saturates at least the electrode material either before or after knitting, and an ionically permeable electronic separator allows the electrodes to be in close proximity to each other without being in electrical contact with each other. A heating element may also be formed by knitting at least one of the first and second conductive yarns into a linear resistor or by knitting an insulated conductive yarn into a sheet of fabric. Such a heating element is connected to the supercapacitor via a switch.

Abstract: A structure for enhancing condensation and wetting dynamics includes a substrate and a plurality of grooves formed in the substrate, forming fins. The fins having fin tops and a coating is applied over the fin tops.

Abstract: A polymerizable monomer prepared by reacting at least one epoxidized cardanol with (meth)acrylic anhydride or (meth)acryloyl chloride in the presence of one or more of triethylamine, tertiary amines, pyridines and pyridine derivatives; wherein the epoxidized cardanol is formed by epoxidation of an unsaturation site of a cardanol having the formula: wherein R is selected from hydrogen and an alkyl, or alkenyl group having 1-6 carbon atoms, and n is 7, 10, or 13, a polymer and resin made form the polymerizable monomer, and a method of preparing such a polymer. The resin created from this monomer is suitable for moderate temperature composites and coatings applications.

Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.

Abstract: Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.

Abstract: A nanofiber mat comprises metal oxide nanoparticles distributed on surface of metal oxide nanofibers, wherein the nanofiber mat has a surface area at least 150 m2/g, and the metal oxide is selected from titanium monoxide TiOx, wherein 0.65<x<1.25, niobium monoxide NbOx, wherein 0.982<x<1.008, vanadium (II) oxide VOx, wherein 0.79 <x <1.29, iron (II) oxide FexO, wherein 0.833<x<0.957, manganese (II) oxide MnxO, wherein 0.848<x<1.000, titanium suboxide, TiOnO2n?1, wherein n>1, molybdenum suboxide, MonO3n?1, wherein n>1, MonO3n?2, wherein n>1, and vanadium suboxide, VnO2n?1, wherein n>1. Cathodes, anodes and batteries are made using the nanofiber mat. Processes for producing the metal oxide nanofiber mat and an electrode including it are also provided.

Abstract: This invention outlines a method for synthesizing a blended resin system in a one pot reaction that may utilize, for example, bio-based anhydrosugars such as isosorbide as a principle component to produce isosorbide dimethacrylate and other monomeric materials for thermosetting applications. This invention establishes a one-pot procedure for reacting a hydroxy group containing compound with methacrylic anhydride in the first step and using the by-product methacrylic acid to react with glycidyl ethers to form additional methacrylate compounds in the second step. This methodology can be formulated to produce a wide array of resin systems that have controlled ratios of hydroxy group containing compound/cross-linker/reactive diluent. Additionally, the novel resin systems may be partially to fully bio-based, promoting global sustainability and reducing costs, and when free radically polymerized have properties that meet or exceed their petroleum derived counterparts.

Abstract: A solid polymer electrolyte including a comb-chain crosslinked network formed by reacting poly(glycidyl methacrylate) with a functionalized poly(ethylene glycol) or functionalized poly(ethylene oxide). Batteries including the solid polymer electrolytes, a cathode, and a metal anode or one or more lithium salts are also described. A process of preparing the solid polymer electrolyte involves reacting a poly(glycidyl methacrylate) with a functionalized poly(ethylene glycol) or functionalized poly(ethylene oxide) to form a crosslinked network in a single-step polymerization process. The solid polymer electrolyte provides improved resistance to lithium dendrite formation and has excellent physical and electrical properties that make it particularly suitable for use in lithium batteries.

Abstract: A soft magnetic composite comprising an iron or iron alloy ferromagnetic material coated with an oxide material. An interface between the ferromagnetic material and the layer of oxide contains antiphase domain boundaries. Two processes for producing a soft magnetic composite are also provided. One process includes depositing an oxide layer onto an iron or iron alloy ferromagnetic material by molecular beam epitaxy at a partial oxygen pressure of from 1×10?5 Torr to 1×10?7 Torr to form a coated composite. The other process includes milling an iron or iron alloy ferromagnetic material powder and an oxide powder by high-energy milling to form a mixture; compacting the mixture and curing in an inert gas atmosphere at a temperature from 500° C. to 1200° C. to form a soft magnetic composite.