Patents Assigned to DSM
  • Patent number: 10947573
    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein the amounts of formed hydrolysed oxidation products at the end of the enzymatic hydrolysis by the oxidation by LPMO of the lignocellulosic material containing cellulose and/or cello-oligosaccharides is kept between 3 to 80 g/kg glucan present in the lignocellulosic material by adding a s
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: March 16, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Bertus Noordam, Loes Elizabeth Bevers, Rudy Francois Maria Jozef Parton, Michael Petrus Jozef Berkhout
  • Patent number: 10941421
    Abstract: The present invention relates to processes for producing ethanol from lignocellulosic hydrolysates comprising, hexoses, pentoses and acetic acid, whereby genetically modified yeast cells are use that comprise an exogenous gene encoding an acetaldehyde dehydrogenase and a bacterial gene encoding an enzyme with NAD+-linked glycerol dehydrogenase activity. The process is further characterised in that glycerol is present in or fed into the culture medium, whereby the modified yeast cell ferments the hexoses, pentoses, acetic acid and glycerol to ethanol. The invention further relates to yeast cells for use in such processes. The yeast cells advantageously comprise genetic modifications that improve glycerol utilization such as modifications that increase one or more of dihydroxyacetone kinase activity and transport of glycerol into the cell.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: March 9, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Adrianus Maria De Bont, Aloysius Wilhelmus Rudolphus Hubertus Teunissen, Paul Klaassen, Wouter Willem Antonius Hartman, Shimaira Van Beusekom
  • Patent number: 10933002
    Abstract: The present invention relates to topical compositions comprising phytantriol and erythrulose as well as the use thereof for preservation boosting.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 2, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventor: Christine Mendrok-Edinger
  • Patent number: 10925850
    Abstract: The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 23, 2021
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, Paul Warren Behrens, Jon Milton Hansen, Joseph W. Pfeifer, III, Tracey Lynn Stahl, Ross Zirkle
  • Patent number: 10927399
    Abstract: The present invention relates to a method of identifying a heterologous polypeptide having enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA in (the cytosol of) a yeast cell comprising: a) providing a mutated yeast cell comprising a deletion of at least one gene of the (PDH) by-pass, selected from the genes encoding the enzymes pyruvate decarboxylase (PDC), acetaldehyde dehydrogenase (ALD), and acetyl-CoA synthetase (ACS); b) transforming said mutated yeast cell with an expression vector comprising a heterologous nucleotide sequence encoding a candidate polypeptide having potential enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA; c) testing said recombinant mutated yeast cell for its ability to grow on minimal medium containing glucose as sole carbon source, and d) identifying said candidate polypeptide as a heterologous polypeptide having enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA in (the cytosol of
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: February 23, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ulrike Maria Mueller, Liang Wu, Lourina Madeleine Raamsdonk, Aaron Adriaan Winkler
  • Publication number: 20210045982
    Abstract: The present invention relates to topical compositions comprising at least one liquid UV-filter and a nano-sized 1,4-di(benzoxazol-2?-yl)benzene.
    Type: Application
    Filed: March 19, 2019
    Publication date: February 18, 2021
    Applicant: DSM IP Assets B.V.
    Inventors: Christine MENDROK-EDINGER, Alexander SCHLIFKE-POSCHALKO
  • Patent number: 10920207
    Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: February 16, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alrik Pieter Los, Cornelis Maria Jacobus Sagt, Margot Elisabeth Francoise Schooneveld-Bergmans, Robbertus Antonius Damveld
  • Patent number: 10918113
    Abstract: The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 53, 112, 141, 178, 179, 182, 202, 203, 235, 282, 284, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2. Such a variant polypeptide may be used in the preparation of a baked product.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 16, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Rene Marcel De Jong, Chantal Christis, Neil Carr
  • Patent number: 10920026
    Abstract: The present invention relates to a polymer composition, consisting of (A) 30-90 wt. % of at least one thermoplastic polymer comprising at least a semi-crystalline semi-aromatic polyamide (SSPA-1) in an amount in the range of 30-90 wt. %; (B) 10-70 wt. % of at least one reinforcing agent, and (C) 0-25 wt. % of one or more other components; wherein the SSPA-1 consists of (A-1-a) 90-100 wt. % of repeat units derived from (i) an aromatic dicarboxylic acid and (ii) diamines, and (A-1-b) 0-10 wt. % of repeat units derived from other monomers; the diamines (ii) consist of 80-95 mole % of a linear aliphatic diamine, 5-20 mole % of 2-methyl-pentamethylene diamine, and 0-10 mole % of other diamines; and the SSPA-1 has a melting temperature (Tm) of at least 300° C. The invention further relates to a molded part made of the composition, a process for making the composition and a process for making the molded part.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 16, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventor: Zhujuan Wang
  • Patent number: 10913928
    Abstract: This invention relates to a recombinant cell, preferably a recombinant yeast cell comprising: a) a gene coding for an enzyme having glycerol-3-phosphate dehydrogenase activity, wherein said enzyme has a cofactor dependency for at least NADP+ and/or for NADPH; b) a gene encoding an enzyme having at least NAD+ dependent acetylating acetaldehyde dehydrogenase activity (EC 1.2.1.10); and c) a mutation or disruption in at least one gene selected from the group of GPD1 and GPD2. Said cell is suitable for ethanol production, has a reduced glycerol production at high ethanol yield.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 9, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ioannis Papapetridis, Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk
  • Patent number: 10913859
    Abstract: The invention relates to thermosetting powder coating compositions as disclosed herein, said compositions comprising one or more unsaturated resins comprising ethylenic unsaturations, one or more curing agents, and one or more thermal radical initiators, wherein at least one of the initiators is a peroxydicarbonate-X. The invention further relates to a process for making said thermosetting powder coating compositions and processes for coating an article with said thermosetting powder coating compositions. The invention further relates to cured thermosetting powder coating compositions obtained by curing of the thermosetting powder coating compositions of the invention. The invention further relates to an article having coated thereon said thermosetting powder coating composition as well as to an article having coated and cured thereon said thermosetting powder coating composition.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 9, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Gertrudis Christianus Bongaerts, Dragos Popescu
  • Patent number: 10913965
    Abstract: The present disclosure relates to a novel method, expression vectors, and host cells for producing nicotinamide riboside by regulating the pathways that lead to the production of nicotinamide riboside.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: February 9, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Adam G. Lawrence, Celine ViArouge
  • Patent number: 10913938
    Abstract: The invention relates to a polypeptide having cellulolytic enhancing activity, wherein the polypeptide is selected from the group consisting of: (a) a polypeptide comprising an amino acid sequence having at least 60% sequence identity with the amino acid sequence of SEQ ID NO: 2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32, 35, 38, 41, 44 and/or 47; (b) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 60% sequence identity to the nucleotide sequence of SEQ ID NO: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 and/or 48; (c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence which hybridises under at least high stringency conditions with the complementary strand of SEQ ID NO: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 and/or 48; and (d) a fragment of the polypeptide of (a), (b), or (c), that has cellulolytic enhancing activity.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: February 9, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Gustaaf Ernst Van Leeuwen, Loes Elizabeth Bevers
  • Patent number: 10907183
    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein oxygen is consumed in amounts corresponding to between 20 and 5000 mmol molecular oxygen per kg glucan present in the lignocellulosic material, the oxygen is added after the pretreatment and before and/or during the enzymatic hydrolysis of the lignocellulosic material, preferably in an
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: February 2, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Bertus Noordam, Michael Petrus Jozef Berkhout
  • Patent number: 10898424
    Abstract: The present invention relates to a blend comprising palmitoyl tripeptide-5, an algae extract, panthenol, water and optionally pullulan and/or sodium hyaluronate.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: January 26, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Mathias Gempeler, Dominik Imfeld, Dirk Weber, Dominique Crestia
  • Patent number: 10894858
    Abstract: Radiation curable compositions for coating optical fibers are disclosed herein. In an embodiment, a radiation curable composition includes a reactive oligomer component, wherein a portion of the polymerizable groups of the reactive oligomer component include methacrylate groups; a reactive diluent monomer component, wherein a portion of the polymerizable groups of the reactive diluent monomer component include acrylate groups, acrylamide groups, or N-vinyl amide groups, or combinations thereof; a photoinitiator component, and an optional additive component. Also described are methods of coating the radiation curable compositions elsewhere described, and the fiber optic coatings and cables resulting therefrom.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: January 19, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventor: Johan Franz Gradus Antonius Jansen
  • Patent number: 10888531
    Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: George Mihov, Guy Draaisma, Silvana Rensina Antonnietta Di Silvestre, Tristan Handels
  • Patent number: 10888720
    Abstract: The present invention relates to gentiopicroside free Gentiana acaulis and/or Gentiana septemfida extracts. Furthermore, it relates to cosmetic compositions comprising such gentiopicroside free Gentiana acaulis or Gentiana septemfida extract, as well as mixtures thereof.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christophe Boissard, Dominik Imfeld, Marie-Sophie Meisinger, François Paul
  • Patent number: 10889932
    Abstract: The invention pertains to a method for manufacturing a textile product comprising providing a first sheet having a front surface and a back surface, covering the back surface of the sheet with a porous layer having a porosity of 50% to 99%, the layer comprising a thermoplastic material, forming a pile on the front surface of first sheet by stitching one or more yarns through the first sheet, the one or more yarns having a free end that forms the said pile and a locked end that extends into the porous layer, thereby forming an intermediate product, processing the intermediate product by feeding this product along a body having a heated surface, the porous layer being pressed against the said heated surface, to melt at least a fraction of the thermoplastic material, cooling the molten fraction of the thermoplastic, thereby connecting the locked end of the one or more yarns to the first sheet, and optionally connecting a second sheet to the processed intermediate product, using an adhesive applied between the pr
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventor: Chris Reutelingsperger
  • Patent number: 10888538
    Abstract: The present patent application relates to novel polyunsaturated fatty acid salt (PUFA salts) solid formulations.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Elger Funda, Denis Hug, Odile Krainz, Sean McDonnell, Shakuntala Ramnarain, Casey Sumner, Qiong Tang