Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
Type:
Grant
Filed:
January 16, 2019
Date of Patent:
November 10, 2020
Assignee:
DSM IP Assets B.V.
Inventors:
Kirk E. Apt, James Casey Lippmeier, David Simpson, Jun Wang, James P. Wynn, Ross Zirkle
Abstract: The present invention relates to a polypeptide having lipase activity wherein the polypeptide, which, when aligned with a polypeptide according to SEQ ID NO: 1, comprises at least one amino acid substitution resulting in Ser (S), Ala (A) or Leu (L) at position 246, Trp (W) at position 307, Leu (L) at position 345, Ile (I) at position 365, and/or Phe (F) at position 534, wherein the position is defined with reference to SEQ ID NO: 1, wherein Ala(A) at position 1 in SEQ ID NO: 1 is counted as number 1 and a method for preparing the polypeptide. The present invention further relates to a process for preparing a food product wherein a polypeptide according to the present invention is used.
Type:
Grant
Filed:
June 8, 2017
Date of Patent:
November 10, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rene Marcel De Jong, Willem Bijleveld, Evert Tjeerd Van Rij
Abstract: The present invention pertains to a method to manufacture a textile product comprising a first sheet having a width and a length, and polymer yarns fastened to this sheet to form a pile thereon, the method comprising providing the sheet, stitching the polymer yarns through the sheet to form the pile on a first surface of the sheet and loops of the yarns at a second surface of the sheet, transporting the sheet in a direction parallel to its length along a heating element, the heating element being directed to the second surface of the sheet, heating the second surface with the heating element to at least partly melt the loops of the yarns to fasten the yarns to the sheet, wherein the method comprises transporting the sheet in contact with the heating element, wherein the heating element is a stationary rigid plate-like element having a width corresponding to the width of the sheet, and a length that extends parallel to the length of the sheet, the plate being curved in its length direction, wherein the outer c
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
October 27, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Chris Reutelingsperger, Reinard Jozef Maria Steeman, Wilhelmus Theodorus Maria Van Roij
Abstract: The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.
Type:
Grant
Filed:
December 19, 2019
Date of Patent:
October 27, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Ulla Letinois, Stephan Ackermann, Jonathan Alan Medlock, Hajo Lehmann
Abstract: Disclosed are anti-fouling and optionally specific binding surfaces, methods for forming anti-fouling and optionally specific binding surfaces, and molecules that may be useful for forming anti-fouling and optionally specific binding surfaces. The surfaces may be formed by employing a molecule comprising a poly(2-oxazoline) having functional groups. In an embodiment, the poly(2-oxazoline) comprises a carboxyl endgroup, an amine endgroup, an N-hydroxysuccinimide endgroup, an oxirane endgroup, an oxetane endgroup, or an isocyanate endgroup, which may enable attachment of a specific binding moiety to the poly(2-oxazoline). In an embodiment, the poly(2-oxazoline) molecule comprises a (meth)acrylate functionality that may allow for attachment to a surface comprising a moiety capable of nucleophilic conjugate addition.
Type:
Grant
Filed:
March 3, 2017
Date of Patent:
October 27, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Mengmeng Zong, Aylvin Jorge Angelo Athanasius Dias, Edith Elisabeth M Van Den Bosch, Jun Qiu
Abstract: The present invention relates to storage-stable formulations of 3-nitrooxypropanol and derivatives thereof as well as to the production of such formulations.
Abstract: The invention relates to a flame retardant polyamide composition comprising (A) a semi-crystalline semi-aromatic polyamide, (B) a semi-crystalline aliphatic polyamide and (C) a halogen free flame retardant system comprising a metal salt of a (di)phosphinic acid, a melamine condensation product, a polyphosphate salt of melamine or a polyphosphate salt of a melamine condensation product, or any mixture thereof; wherein the weight ratio of (A):(B) is in the range of 75:25-98:2, and (B) has a number average molecular weight (Mn) of more than 7500 g/mol. The invention also relates to an article made of the flame retardant polyamide composition.
Type:
Grant
Filed:
May 8, 2012
Date of Patent:
October 20, 2020
Assignee:
DSM IP ASSETS B.V.
Inventor:
Frank Peter Theodorus Johannes Van Der Burgt
Abstract: The invention pertains to a method to manufacture a textile product comprising a first sheet having polymer yarns fastened to this sheet to form a pile thereon, the method comprising providing the sheet, stitching the polymer yarns through the sheet to form the pile on a first surface of the sheet and loops of the yarns at a second surface of the sheet, heating the second surface of the sheet to at least partly melt the loops of the yarns to fasten the yarns to the sheet, wherein the method comprises measuring a roughness of the second surface with the at least partly molten loops of the yarns thereon, after the at least partly molten loops have solidified and, if the roughness differs from a predetermined surface roughness, adapting the method to manufacture the textile product, in order to obtain a second surface roughness that differs from the measured surface roughness. The invention also pertains to a device for applying this method.
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
Type:
Grant
Filed:
February 17, 2017
Date of Patent:
October 13, 2020
Assignee:
DSM IP Assets B.V.
Inventors:
Kirk E. Apt, Paul Warren Behrens, Jon Milton Hansen, Joseph W. Pfeifer, III, Tracey Lynn Stahl, Ross Zirkle
Abstract: The present invention relates to a method for carrying out recombination at a target locus.
Type:
Grant
Filed:
March 12, 2013
Date of Patent:
October 6, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Nathalie Wiessenhaan, Catharina Petronella Antonia Maria Kolen, Bernard Meijrink, Viktor Marius Boer, Johannes Andries Roubos, Yvonne Johannes Odilia Arendsen
Abstract: A compressed air turbine DC power generator system, comprising: an aerodynamic turbine engine; a direct current generator (2) used for generating a direct current by using power output of the aerodynamic turbine engine as a driving input; and a control unit (3) used for controlling the rotating speed of the aerodynamic turbine engine to generate the power output and adjusting the output current and/or the output voltage of the direct current generator (2). The compressed air turbine DC power generator system is miniaturized and has high integration level, effectively overcomes the disadvantages such as low power density and great vibration noise of a power generation system with an internal combustion engine, and has a high industrial application value. The compressed air turbine DC power generator system can be used as an auxiliary power supply in the development process of an electric automobile, thereby effectively resolving the problem of range anxiety of a pure electric automobile.
Abstract: This disclosure concerns a novel modular docosahexaenoic acid (DHA) synthase and recombinant host organisms genetically modified with such synthase and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.
Type:
Grant
Filed:
June 6, 2016
Date of Patent:
October 6, 2020
Assignee:
DSM IP Assets B.V
Inventors:
James G. Metz, Jun Wang, Bastien Chevreux, Ross E. Zirkle, Anne-Cecile Bayne, James Casey Lippmeier
Abstract: The present invention relates to topical compositions comprising 10-hydroxystearic acid or a salt thereof and at least one nonionic emulsifier. The present invention also relates to a method to retard or inhibit the re-crystallisation of 10-hydroxystearic acid or a salt thereof in a topical composition, said method comprising formulating 10-hydroxystearic acid or a salt thereof in the presence of at least one nonionic emulsifier.
Abstract: Provided is a process to produce a yeast-derived product as well as a yeast autolysate or yeast extract comprising at least 1% w/w reducing sugar based on the total dry matter weight of the yeast extract or yeast autolysate. Also provided is a process to produce a reaction flavour. The yeast extract or yeast autolysate is very suitable for the production of a reaction flavour.
Abstract: The present invention relates to a recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a mutant malate dehydrogenase resulting in an increased production of the dicarboxylic acid. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting said recombinant host cell in a suitable fermentation medium and producing the dicarboxylic acid.
Type:
Grant
Filed:
July 11, 2017
Date of Patent:
September 29, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Alrik Pieter Los, Rene Marcel De Jong, Remko Tsjibbe Winter, Ben Den Dulk
Abstract: The invention provides a new fermentation process for producing gellan gum, which can control the feeding amount and feeding speed of the nitrogen sources accurately and quantitatively, and control the growth and gum production of the strains, so as to significantly improve the controllability, stability and yield of the fermentation process for producing gellan gum.
Type:
Grant
Filed:
June 19, 2018
Date of Patent:
September 8, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Jie Zhao, Zhihui Gao, Wouter Adrianus Van Winden, Rogier Meulenberg
Abstract: The current invention relates to a process for preparing an aqueous binder composition free of organic solvent, the process comprising at least the following steps: A) preparing a hydrophilic vinyl polymer (Polymer A) by polymerisation of a monomer composition A that contains: Ai) at least one carboxylic acid functional olefinically unsaturated monomer; and Aii) at least one olefinically unsaturated monomer different than Ai); and Aiii) optionally at least one wet adhesion promoting olefinically unsaturated monomer different than Ai and Aii); where Polymer A has an acid value (AV) from 32 to 98 mg KOH/g of solid Polymer A; B) preparing a hydrophobic vinyl polymer (Polymer B) by emulsion polymerization of a monomer composition B in the presence of Polymer A where the monomer composition B contains: Bi) at least one olefinically unsaturated monomer; Bii) optionally carboxylic acid functional olefinically unsaturated monomer different than Bi); and Biii) optionally wet adhesion promoting olefinically unsaturated
Abstract: The invention relates to a fibrous tape comprising fused polymeric fibers, said fibrous tape having a tape thickness and a tape width and being characterized by a coefficient of variation (CV) of the tape thickness across the tape width of at most 6%.
Type:
Grant
Filed:
December 13, 2011
Date of Patent:
September 8, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Roelof Marissen, Koen van Putten, Antoon Maria Verspagen