Patents Assigned to DSM
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Patent number: 10689681Abstract: The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.Type: GrantFiled: June 2, 2014Date of Patent: June 23, 2020Assignee: DSM IP ASSETS B.V.Inventors: Viktor Marius Boer, Erwin Suir
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Patent number: 10682334Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.Type: GrantFiled: October 22, 2018Date of Patent: June 16, 2020Assignee: DSM IP ASSETS B.V.Inventors: Szabolcs Peter, Joseph Schwager, Weerasinghe M. Indrasena, Jaroslav A. Kralovec, Bernd Mussler
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Patent number: 10676637Abstract: The invention relates to a thermosetting powder coating composition B (PCC B) comprising a physical mixture of a thermosetting powder coating composition A (PCC A) with a separate, distinct thermosetting powder coating composition A1 (PCC A1). The invention further relates to a process for making said thermosetting powder coating composition B and processes for coating an article with said PCC B. The invention further relates to a cured PCC B. The invention further relates to an article having coated thereon said thermosetting powder coating composition B as well as to an article having coated and cured thereon said thermosetting powder coating composition B. The invention further relates to use of: the PCC B, the cured PCC B, articles coated with the PCC B, articles having coated and cured thereon the PCC B. The invention further relates to the use of the PCC B for matt powder coatings.Type: GrantFiled: July 9, 2015Date of Patent: June 9, 2020Assignee: DSM IP Assets B.V.Inventors: Matthias Johannes Cornelis Bos, Paulus Franciscus Anna Buijsen, Johannes Albertus Hettinga
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Patent number: 10676844Abstract: The invention relates to a process for the preparation of a gel spun UHMWPE fiber comprising the steps of providing an ultra high molecular weight polyethylene composition having an intrinsic viscosity (IV) of at least 8 dl/g, a co-monomer content (CBR) of a least 0.05 SCB/1000TC, a mass averaged distribution of the co-monomer (CMAD) of at least 0.05, wherein the co-monomer has at least 4 carbon atoms, dissolving the composition in a solvent to form a polymer solution having a UHMWPE concentration of between 2 and 40 wt %, spinning the polymer solution through a multi orifice die plate to form a solution fibers, cooling the solution fiber to below 80° C. to form a gel fiber, drawing the fiber in at least one step to form a drawn fiber, removing at least a portion of the solvent before, during or after the drawing, wherein the ratio CMAD to CBR is greater than 1.0. The invention further relates to a gel-spun UHMWPE fiber obtainable by the process and products comprising said gel-spun UHMWPE fiber.Type: GrantFiled: December 12, 2016Date of Patent: June 9, 2020Assignee: DSM IP ASSETS B.V.Inventors: Tom Antonius Philomena Engels, Gert De Cremer, Romain Berthoud, Roman Stepanyan, Peter Roozemond, Filip Stefan Emiel Oosterlinck, John Richard Severn
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Patent number: 10676764Abstract: The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.Type: GrantFiled: July 14, 2016Date of Patent: June 9, 2020Assignee: DSM IP ASSETS B.V.Inventors: Mae Joanne Aguila, Hans-Peter Hohmann, Laurent Lefort, Jonathan Alan Medlock, Guenter Pappenberger
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Patent number: 10672928Abstract: A metal foil pattern layered body of the invention includes a base member; a metal foil including a metal pattern formed by an opening and a metal portion; and a protuberance provided at the metal foil and at a boundary between the opening and the metal portion.Type: GrantFiled: August 25, 2017Date of Patent: June 2, 2020Assignee: DSM IP ASSETS B.V.Inventors: Koichi Kumai, Ryuji Ueda, Takao Tomono, Takehito Tsukamoto
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Patent number: 10669554Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).Type: GrantFiled: November 29, 2017Date of Patent: June 2, 2020Assignees: Dow AgroSciences LLC, DSM IP ASSETS B.V.Inventors: Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Paul Gordon Roessler, James Metz, Scott Bevan, Jerry Kuner
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Patent number: 10668133Abstract: This invention is directed to the use of a protein hydrolysate, and in particular an egg lysozyme hydrolysate to assist an animal, including a human in overcoming an addition, or by breaking an unwanted habit.Type: GrantFiled: December 13, 2016Date of Patent: June 2, 2020Assignee: DSM IP ASSETS B.V.Inventors: Guillen Santiago Eusebio Fernandez-Reumann, Regina Goralczyk, Joris Kloek, Marijn Christoffel Waander Kroes, Hasan Mohajeri, Guido Alexander Van Wingen, Jonas Wittwer
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Patent number: 10668088Abstract: This invention relates to the use of the combination of 25-hydroxyvitamin D3 (“25-OH D3”) and antioxidants/anti-inflammatories (ascorbic acid, vitamin E and at least one carotenoid) to make a pharmaceutical, nutraceutical or food supplement which can ameliorate various problems observed in humans connected with polycystic ovarian 5 syndrome and cardiovascular diseases. Pharmaceuticals, nutraceuticals and food supplements containing the 25-OH D3 and antioxidants/anti-inflammatories and premixes are also provided.Type: GrantFiled: January 15, 2016Date of Patent: June 2, 2020Assignee: DSM IP ASSETS B.V.Inventors: Shuen Ei Chen, Thau Kiong Chung, Daniel Raederstorff, Wolfgang Schalch
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Patent number: 10665742Abstract: This invention relates to a solar-cell module backing layer obtained by co-extruding obtained by melt co-extruding (i) a first polymer composition comprising (a) a polyamide, (b) an elastomer and (c) an elastomer that contains groups that bond chemically and/or interact physically with the polyamide, and wherein the first polymer composition comprises from 10 to 90 wt. % of the polyamide (a) and from 10 to 90 wt. % of the elastomer (b) and (c) (of the total weight of polyamide (a) and elastomer (b) and (c) present in the first polymer composition) and (ii) a second polymer composition comprising from 50-98 wt. % of elastomer and from 0.15-5 wt. % of groups (based on the total weight of the second polymer composition) that bond chemically and/or interact physically with the solar cell and optionally with the first polymer composition.Type: GrantFiled: July 1, 2015Date of Patent: May 26, 2020Assignee: DSM IP ASSETS B.V.Inventors: Franciscus Gerardus Henricus Van Duijnhoven, Guido Jozefina Wilhelmus Meijers
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Patent number: 10663265Abstract: Material sheets are provided which include at least one monolayer, wherein the at least one monolayer has a plurality of drawn unidirectional polymer fibers having a strength of greater than 1.2 GPa and a thickness of less than 100 ?m, and wherein the material sheet includes a bonding agent of less than 13 wt % relative to the total weight of the material sheet.Type: GrantFiled: December 6, 2016Date of Patent: May 26, 2020Assignee: DSM IP ASSETS B.V.Inventors: Roelof Marissen, Reinard Jozef Maria Steeman, Leonard Josef Arnold Nielaba
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Patent number: 10655115Abstract: The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72.Type: GrantFiled: January 17, 2019Date of Patent: May 19, 2020Assignee: DSM IP ASSETS B.V.Inventors: Alrik Pieter Los, Rene Marcel De Jong, Maaike Appeldoorn
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Patent number: 10655940Abstract: The invention relates to a ballistic resistant sheet (12) comprising a three-layer hybrid structure, with a core layer (12-1) and two face layers (12-2; 12-3) wherein the core layer comprises at least one first monolayer comprised of first unidirectionally (UD) oriented fibers and a matrix material, and wherein each of the face layers comprise at least one second and at least one third monolayer comprised of second UD oriented fibers and third UD oriented fibers respectively and wherein the stiffness of the face layers is higher than the stiffness of the core layer.Type: GrantFiled: February 5, 2016Date of Patent: May 19, 2020Assignee: DSM IP ASSETS B.V.Inventor: Zhi-Yi Li
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Patent number: 10653613Abstract: Trp-containing peptides, preferably from hen's egg hydrolysate can increase the Cys levels in blood serum. This results in increased keratin production, and enhances growth, appearance, and/or volume in keratin-containing tissue including skin, hair, and/or nails.Type: GrantFiled: November 28, 2014Date of Patent: May 19, 2020Assignee: DSM IP ASSETS B.V.Inventors: Regina Goralczyk, Hasan Mohajeri, Jonas Wittwer Schegg
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Patent number: 10646884Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: December 14, 2017Date of Patent: May 12, 2020Assignee: DSM IP ASSETS B.V.Inventors: John E. Nash, William T. Fisher, Douglas G. Evans
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Patent number: 10647792Abstract: Particulate ultra high molecular weight polyethylene (pUHMWPE) are disclosed having an intrinsic viscosity (IV) of at least 4 dl/g, a molecular weight distribution Mw/Mn of less than 4.0, a median particle size D50 of between 50 and 200 ?m, a residual Ti-content of less than 10 ppm, a residual Si-content of less than 50 ppm, and a total ash content of less than 1000 ppm.Type: GrantFiled: August 30, 2017Date of Patent: May 12, 2020Assignee: DSM IP ASSETS B.V.Inventors: John Richard Severn, Romain Berthoud, Timothy James Kidd
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Patent number: 10651320Abstract: A method of manufacturing a circuit board includes: forming a plurality of metal electrodes so as to be separated from each other on a holding sheet by cutting a metal foil held on the holding sheet to remove a portion of the metal foil; forming adhesive layers on surfaces of the plurality of metal electrodes; adhering the adhesive layers to a base material by closely contacting the adhesive layers with the base material; and transcribing the adhesive layers and the plurality of metal electrodes onto the base material by detaching the holding sheet from the plurality of metal electrodes.Type: GrantFiled: May 2, 2019Date of Patent: May 12, 2020Assignee: DSM IP ASSETS B.V.Inventors: Koichi Kumai, Ryuji Ueda, Kentaro Kubota, Shigeki Kudo, Minoru Kawasaki
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Patent number: 10633684Abstract: The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.Type: GrantFiled: November 9, 2009Date of Patent: April 28, 2020Assignee: DSM IP ASSETS B.V.Inventors: Martin Lehmann, Hans-Peter Hohmann, Dietmar Laudert, Michael Hans
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Patent number: 10632652Abstract: A material sheet is formed of a woven fabric of polymer tapes, wherein the width of a tape varies less than 2% on average in the longitudinal direction of the tape. Processes for the preparation of the material sheet, and to a ballistic resistant article comprising the material sheet are also provided. A ballistic resistant article which includes the material sheet exhibits excellent antiballistic properties.Type: GrantFiled: January 15, 2019Date of Patent: April 28, 2020Assignee: DSM IP ASSETS B.V.Inventors: Reinard Jozef Maria Steeman, Marcel Jongedijk, Johann Van Elburg
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Patent number: 10633678Abstract: The present invention provides a process for the production of a microbial oil comprising culturing a micro-organism in a two stage fermentation process where, in a last stage that precedes the end of fermentation, the carbon source is: consumed by the micro-organisms at a rate greater than it is added to the medium; added at a rate #0.30 M carbon/kg medium; or is rate limiting on the growth of the micro-organism. The micro-organisms thus have the carbon source restricted so that they preferentially metabolise fats or lipids other than arachidonic acid (ARA), so increasing the proportion of ARA in the cells. A microbial oil is then recovered from the micro-organism, using hexane as a solvent, that has at least 50% ARA and at least 90% triglycerides.Type: GrantFiled: September 16, 2013Date of Patent: April 28, 2020Assignee: DSM IP ASSETS B.V.Inventors: Hugo Streekstra, Petrus Joseph Maria Brocken