Patents Assigned to DSM
  • Efficient process of asymmetric hydrogenation of unsaturated ketones using additives
    Patent number: 10047019
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: August 14, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jonathan Alan Medlock, Gerardus Karel Maria Verzijl, Edwin Gerard Ijpeij, Andreas Hendrikus Maria De Vries
  • Process for the production of biaryl compounds
    Patent number: 10040732
    Abstract: Process for producing biaryl compounds by aerobic cross dehydrogenative coupling (CDC) of two arene groups comprising at least one aryl carbon-hydrogen bond, in the presence of a catalyst system comprising a palladium salt comprising at least one non-cyclopalladatable carboxylate anion and one or more non-beta-eliminatable, non-cyclopalladatable ligands comprising at least one N-donor atom, the one or more ligands having a 0.5/1-1.5/1 molar ratio of N-donor atoms relative to the Pd atoms.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 7, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventor: Paulus Lambertus Alsters
  • Prosthetic valve and method of making a prosthetic valve
    Patent number: 10039640
    Abstract: The invention relates to a prosthetic valve comprising a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: August 7, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
  • Phage insensitive
    Patent number: 10041135
    Abstract: Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: August 7, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Roelof Hendrik Matthijs Kouwen, Pim Van Hee, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
  • Process for producing a thermoplastic polymer containing segments of a diamide
    Patent number: 10040904
    Abstract: Process for the production of a thermoplastic polymer comprising segments of a diamide, the process comprising: 1) a first step of preparing a reaction mixture comprising a diamine H2N—Y—NH2 Form. (I), and a diester of a dicarboxylic acid Form. (II) 2) a second step of heating the reaction mixture to a temperature at least 5° C. above the crystallization temperature of the diester and a least 5° C. below the melting temperature of the formed amide (formula III) in the presence of an alkaline or earth alkaline alkoxy catalyst Form. (III) wherein X and Y are the same or different and are an aliphatic group comprising 2-12 carbon atoms or an aromatic group comprising 6-20 carbon atoms, R1 and R2 are the same or different and are an aliphatic group comprising 2-15 carbon atoms and wherein R equals R1 or R2 and are the same or different.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 7, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Wilhelmus Petrus Johannes Appel, Carel Frederik Constantijn Fitié, Atze Jan Nijenhuis, Beert Jacobus Keestra, Josien Krijgsman, Michel Henri Chrétien Joseph Van Houtem, Henricus Marie Janssen
  • Deaeration process
    Patent number: 10041097
    Abstract: A process for producing an oil, or a polyunsaturated fatty acid (PUFA), is described where an aqueous liquid comprising cells is deaerated, and the oil or PUFA is obtained from the cells. Deaeration can be performed by a wide variety of techniques, including the application of a vacuum (or reduced pressure), mechanical deaeration or degassing by reduced stirring or subjecting the broth to centrifugal forces, reducing viscosity (by dilution or heating), reduction in the supply of oxygen or air during fermentation or a reduction in stirring rate, lowering the pH (to lower the solubility of CO2), filtration using PTFE capillaries, gas displacement (by bubbling in nitrogen or helium) or chemical deaeration (using oxygen scavengers).
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: August 7, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: Albert Schaap, Daniel Verkoeijen
  • Host cell capable of producing enzymes useful for degradation of lignocellulosic material
    Patent number: 10035999
    Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filam-tous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be use in a process for the saccharification of cellulosic material.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 31, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alrik Pieter Los, Cornelis Maria Jacobus Sagt, Margot Elisabeth Francoise Schooneveld-Bergmans, Robbertus Antonius Damveld
  • AgsE-deficient strain
    Patent number: 10035986
    Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: July 31, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
  • Method for producing specific ?, ?-unsaturated aldehydes
    Patent number: 10029970
    Abstract: The present invention relates to an improved method for producing specific ?, ?-unsaturated aldehydes.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 24, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jan Schuetz, Bettina Wuestenberg
  • Process for preparing a diamine/dicarboxylic acid salt
    Patent number: 10029977
    Abstract: The present invention also relates to a process for preparing a diamine/dicarboxylic acid salt wherein the dicarboxylic acid comprises an aromatic dicarboxylic acid and is provided in a powder form; the diamine is provided in a liquid form gradually dosed to the dicarboxylic acid powder, while keeping the dicarboxylic acid powder in constant movement; the processing temperature is above 0° C. and below the boiling temperature of the diamine and the melting temperature of the acid and the salt, and the reaction mixture comprises at most 5 wt. % of water. The present invention also relates to an anhydrous diamine/dicarboxylic acid salt obtainable by the process according to invention, or any embodiment thereof as described above.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: July 24, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Eric Grolman, Rudy Rulkens
  • Formulation of sparingly soluble compounds by hot-melt extrusion
    Patent number: 10022337
    Abstract: The present invention relates to formulation of sparingly-(water)-soluble compounds and its use as (or in a) food or feed product or dietary supplement.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: July 17, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alexandra Teleki, Camille Adler
  • Flame retarded thermoplastic moulding composition
    Patent number: 10017628
    Abstract: The invention relates to a flame retarded thermoplastic moulding composition comprising (A) a polyamide (B) a flame retardant system comprising a metal salt of a phosphinic acid and/or a diphosphinic acid; and either (C) a fibrous reinforcing agent; or (D) an inorganic filler; or a combination of (C) and (D), wherein (A) consists primarily of a semi-crystalline semi-aromatic polyamide (A1) with a melting temperature of at least 310° C. and consisting of repeat units, predominantly derived from terephthalic acid and diamines selected from C2-C8 diamines and having a molar average number of carbon atoms of at most 7.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 10, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Hoekstra, Pim Gerard Anton Janssen
  • Biphasic implant device providing joint fluid therapy
    Patent number: 10016278
    Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: July 10, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Gino Bradica, William Christian Wattengel, Timothy A. Ringeisen
  • Methods of Improving Animal Performance
    Publication number: 20180184688
    Abstract: The present invention relates to methods of improving animal performance using animal feed comprising microbial polypeptides having lysozyme activity.
    Type: Application
    Filed: July 4, 2016
    Publication date: July 5, 2018
    Applicants: Novozymes A/S, DSM IP Assets B.V.
    Inventors: Raffaella Aureli, Estefania Perez Calvo, Rual Lopez Ulibarri, Dorthe Hoej Sandvang, Juliane Charlotte Gregaard Thoegersen, Peter Bjarke Olsen, Preben Nielsen, Marianne Thorup Cohn
  • Process of production of 1-(5,5-dimethylcyclohex-1-en-1-yl)ethanone and 1-(5,5-dimethylcyclohex-6-en-1-yl )ethanone
    Patent number: 10005710
    Abstract: The present invention relates to an improved method for producing of 1-(5,5-dimethylcyclohex-1-en-1-yl)ethanone and 1-(5,5-dimethylcyclohex-6-en-1-yl)ethanone.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: June 26, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Raphael Beumer, Ulla Letinois
  • Methods and compositions comprising 10-hydroxy-2-decenoic acid
    Patent number: 10004711
    Abstract: Disclosed herein are compositions for use in treating anxiety, inflammatory conditions, fertility-related disorders, for increasing cognitive performance and managing weight comprising 10-Hydroxy-2-decenoic acid or a derivative thereof and preferably at least one polyunsaturated fatty acid. The preferred polyunsaturated fatty acid is DHA.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: June 26, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: Michael Weiser, Christopher Butt
  • Polypeptides with permease activity
    Patent number: 10000537
    Abstract: The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 ?3 and a side chain hydrophobicity of 10 to 100 ?tR.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 19, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Klaassen, Paulus Petrus De Waal, Rene Marcel De Jong, Arnold Jacob Mattieu Driessen, Jeroen Gerben Nijland, Hyun Yong Shin
  • Polymeric composition
    Patent number: 9994730
    Abstract: The present invention relates to a radiation curable aqueous coating composition comprising a dispersion of a chain extended polyurethane which dispersion comprises (a) a polyurethane-urea polymer comprising (i) acryloyl groups present in an amount of at least 2.0 mmol per g of the polyurethane-urea polymer; and (ii) urea groups present in an amount of at least 0.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 12, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ronald Tennebroek, Ilse Van Casteren
  • Straight female electrical connector with locking arm
    Patent number: D824856
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: August 7, 2018
    Assignee: DSM&T Company, Inc.
    Inventor: Sergio Corona
  • Male electrical connector with locking tabs
    Patent number: D824862
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: August 7, 2018
    Assignee: DSM&T Company, Inc.
    Inventor: Sergio Corona