Abstract: The present disclosure provides methods and compositions for detecting and treating acute transplant rejection.

Abstract: Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER2 polypeptide or a truncation, deletion or substitution mutant thereof. Methods of using the vaccine including the polynucleotide encoding the HER2 polypeptide to treat a cancer or precancer are also provided. The vaccines may be administered with a cancer therapeutic or prevention agent or a checkpoint inhibitor immunomodulatory agent.

Abstract: Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein.

Abstract: An ultrasound system for imaging a target is provided. The system includes a plurality of transducer elements; at least one transmitter configured to excite at least one of the transducer elements to emit ultrasound energy to the target; a plurality of samplers configured to sample echo signals received by at least some of the plurality of transducer elements, the echo signals comprising acoustic echoes received from the target responsive to the ultrasound energy; a coherence calculator configured to calculate a plurality of coherence values, each of the coherence values corresponding to a measure of similarity between at least two sample echo signals; an estimator configured to estimate a coherence contribution estimate, the coherence contribution estimate comprising an estimate of a contribution of at least one coherence model to the plurality of coherence values.

Abstract: Disclosed herein are compositions and methods for enhancing secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for altering and/or modifying the formation and/or secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for loading extracellular vesicles and or AAV particles with a cargo. Disclosed herein are isolated nucleic acid molecules encoding a polypeptide for promoting the formation of extracellular vesicles and AAV particles in cell or a polypeptide associated with extracellular vesicles and/or AAV particles secreted from a cell.

Abstract: A system includes a controller configured to reconstitute a continuous waveform to a discrete analogue version. The system includes a numerical optimizer configured to determine frequencies of a pulse sequence. The numerical optimizer uses radial motional mode frequencies and a desired gate time. The numerical optimizer generates the pulse sequence by closing phase-space trajectories, disentangling spins and motions, and constraining a Rabi frequency for motional sideband transitions. The system also includes a display configured to illustrate a discrete frequency modulation pulse sequence based on the determined frequencies.

Abstract: The present disclosure provides methods and systems for genetically altering and screening Akkermansia bacteria, including Akkermansia muciniphila. The methods also provide genetically altered bacteria, libraries of genetically altered bacteria and use of such bacteria for treatment of diseases.

Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.

Abstract: A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features.

Abstract: Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.

Abstract: Iron-based photosensitizers, which can be used for solar energy conversion and photoluminescence applications, include an iron complex with N-heterocyclic carbene (NHC) ligands (FeNHC), a linking unit, and a polarizable unit formed of a pi conjugated structure having a one-electron reduction potential more positive than NHC.

Abstract: A method includes receiving, by a mobile computing device from an electroencephalogram (EEG) monitoring headset, an incoming wireless communication signal including an EEG data stream. The method may further include processing, by an application running on the mobile computing device, the received EEG data stream to determine at least one actionable command for at least one peripheral device. The method may also include transmitting, by the mobile computing device to the at least one peripheral device, at least one outgoing wireless communication signal including the at least one determined actionable command.

Abstract: An integrated circuit (IC) protection circuit can include a reconfigurable block that receives a seed value from a tamper-proof memory and generates a dynamic key; an authentication block that receives the dynamic key from the reconfigurable block and taint bits from a scan chain to generate an authentication signature; and an encryptor that encrypts a test pattern response on the scan chain if a mismatch is found between the authentication signature and a test pattern embedded signature.

Abstract: Disclosed herein are novel antibiotic compositions and methods of making and using the same. The antibiotic compositions may comprise LPXH-targeting compounds.

Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.

Abstract: The present disclosure provides systems and methods for targeted nerve stimulation. In particular, the present disclosure provides systems and methods for determining the location of electrode placement providing the most therapeutic benefit for a particular subject. The various embodiments disclosed herein include methods for identifying a target nerve having the strongest representation and/or the strongest subject perception associated with a peripheral nerve in a patient-specific manner.

Abstract: Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.

Abstract: This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.