Abstract: Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D-10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in FIG. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.

Abstract: An automated laser-surgery system for performing a closed-loop surgical procedure is disclosed. The procedure includes forming a post-procedural goal based on a three-dimensional (3D) image of a surgical site, planning a path for a surgical laser signal based on the post-procedural goal, performing a procedural pass by steering the surgical laser signal along the path, measuring the surface of the surgical site after the procedural pass, updating a model based on the measured effect at the surgical site, and evaluating the success of the procedural pass based on the surface measurement and the post-procedural goal. If necessary, a new path is planned based on the post-procedural goal and the surface measurement a new pass based on that path is performed, and the surface is again measured to evaluate the success of the new pass. These operations are repeated as a closed-loop sequence as many times as necessary to achieve success.

Abstract: Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient. The method includes determining automatically one or more radiation treatment beam configuration sets. Further, the method includes presenting the determined one or more radiation beam configuration sets via a user interface.

Abstract: Systems and methods for analysis of liquids by covered fluidic channels integrated onto sensor platforms. According to an aspect, a method includes receiving at least one of a liquid and an analyte of interest into a covered fluidic channel with a predetermined orientation. The method also includes confining at least one of the liquid and the analyte of interest within the covered fluidic channel. The method further includes analyzing properties of at least one of the liquid and the analyte of interest.

Abstract: The present disclosure provides, in part, composition and methods for the treatment of pathological pain and itch.

Abstract: A method and system are provided for guiding a needle to a target location within a subject. The system comprises a probe and a needle guide. The probe includes two or more transducers that are arranged to direct sound waves toward a target location on a subject. The needle guide can be detachably coupled to the probe, and may be used to maintain the needle within viewing planes of the transducers while the needle is inserted into the subject. To facilitate guidance of the needle, a real-time image of the target region can be produced by overlaying images produced by the two or more transducers. Such a system may provide a more adaptive and reliable way to guide the insertion of a needle, allowing for more sophisticated and fool-proof viewing planes, improved versatility, and more ergonomic needle control.

Abstract: Provided herein are methods and compositions for decreasing intraocular pressure in a subject. Also provided are methods and compositions for treating or preventing glaucoma.

Abstract: Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).

Abstract: Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.

Abstract: A method of using an implantable mesh for repairing a tissue defect or reconstructing tissue, wherein the implantable mesh has a mesh body and at least two mesh extensions comprised of mesh extending therefrom, includes positioning the mesh body of the implantable mesh such that the mesh body extends across the tissue defect or tissue to be reconstructed and passing at least one mesh extension through tissue adjacent to the tissue defect or tissue to be reconstructed so as to anchor the implantable mesh to the tissue and resist high tension without dehiscing or migrating from the tissue defect or tissue to be reconstructed.

Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.

Abstract: Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.

Abstract: A system for motion planning for autonomous vehicles can include a plurality of sensors, a plurality of detectors in electrical communication with the plurality of sensors, and a motion planning module in electrical communication with the plurality of detectors and a computing system of an autonomous vehicle. The motion planning module stores a planning graph with each node representing, explicitly or implicitly, time and variables defining a state of the autonomous vehicle, an operating environment, or both the state of the autonomous vehicle and the operating environment. A reconfigurable processor can include a collision detection module and, optionally, a shortest path module. Pre-computed collision data and planning graph data reflecting logical/physical node mapping can be communicated to the processor during a programming phase and used during runtime.

Abstract: This present disclosure provides devices, systems, and methods for the treatment of conditions pertaining to bladder control. In particular, the present disclosure provides devices, systems, and methods directed to the application of electrical stimulation to the proximal urethra and associated nervous tissue to elicit voiding contractions that normalize bladder function.

Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.

Abstract: A waste processing system includes a reactor including an inlet end and an outlet end configured to discharge reactor effluent. The inlet end includes a mixing unit having an oxidizing material input and a waste stream input. The reactor oxidizing material input is configured to receive reactor oxidizing material at a temperature greater than 200° C. and at a pressure greater than 60 atm. A second waste stream input is positioned between the reactor inlet end and the reactor outlet end.

Abstract: Provided herein are devices, systems, and methods for analysis of objects, such as cells. The devices, systems, and methods organize a plurality of objects in a plurality of partitions by trapping an object in a trap and transferring the object to an adjacent partition. The devices, systems, and methods provide for parallel analysis of a plurality of objects.

Abstract: Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.

Abstract: The present invention relates to variants of acid-alpha glucosidase and uses thereof. Said variants are sequence-optimized and/or are linked to a heterogenous signal peptide.

Abstract: Systems and methods for decontaminating a surgical drain and its reservoir are provided. An apparatus is provided in the form of a container having an interior chamber and an expansible opening to the interior chamber for insertion of a surgical drain therethrough. Ultraviolet light emitters are disposed within the interior chamber to emit beams of ultraviolet radiation at the surgical drain and/or its reservoir, thereby killing or neutralizing bacteria and fungus on the drain. Walls forming the expansible opening are collapsible to abut a portion of the inserted drain when inserted into the apparatus, and a fluid tight seal is formed between the drain and the apparatus.