Abstract: Disclosed herein are methods of administering precision gene therapy, treating and/or preventing Alzheimer' disease progression, and reducing expression of APOE and APOE e4. Disclosed herein are isolated nucleic acid molecules, viral vectors, lentiviral vectors, pharmaceutical formulations, host cells, guide RNAs and plasmids for use in the disclosed methods.

Abstract: In various embodiments, the present invention relates to a series of anti-fouling zwitterionic biodegradable thiol-yne elastomers that incorporate degradable C4-C14 dicarboxylic acid-based monomer units made using a nucleophilic thiol-yne polymerization methodology that targets high cis-content at comparable molar masses to provide excellent mechanical properties and zwitterionic side chains that provide anti fouling properties. As each C4-C14 dicarboxylic acid-based monomer unit contains at least two labile ester linkages, altering the stoichiometry of degradable C4-C14 dicarboxylic acid-based monomer unit incorporation allows the degradation rate of the material to be tuned precisely, while retaining control over the mechanical properties by maintaining the cis/trans stereochemistry of the double bonds to provide independent tuning of mechanical and degradative properties.

Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

Abstract: The present disclosure describes an organic-inorganic metal-halide-based semiconducting material that melts at lower temperatures compared to conventional inorganic semiconductors. The hybrid material is structurally engineered to easily access both crystalline and amorphous glassy states, with each state offering distinct physical properties.

Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.

Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.

Abstract: There are no FDA-approved disease-modifying therapies for GSDs like GSD Ia and GSD Ib. Disclosed herein are compositions for and methods of detecting GSD biomarkers as well as methods of diagnosing GSD, methods of determining the efficacy of a GSD treatment, methods of monitoring metabolic control status, and methods of determining the efficacy of regulating dietary intake of carbohydrates using the disclosed biomarkers.

Abstract: The subject matter described herein includes methods, systems, and computer readable media for conducting an automatic assessment of postural control of a subject. According to one aspect, a method occurs at a computing platform including a processor and memory. The method includes displaying a stimulus to which a subject responds, capturing facial image data of the subject, analyzing the facial image data to determine a frequency of head displacement information associated with the subject, using the head displacement information to derive postural control assessment data, and determining that the postural control assessment data is indicative of a neurodevelopmental or neuropsychiatric disorder associated with the subject.

Abstract: The present disclosure provides methods for the treatment of autism spectrum disorders. More particularly, the present disclosure relates to methods of using cord blood for the treatment of autism spectrum disorders.

Abstract: Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.

Abstract: The invention is directed to immunogens and methods for inducing immune responses, comprising methods for germline B cell stimulation and maturation by reverse engineering of HIV-1 envelopes.

Abstract: Compositions and methods of promoting myelination in neurons are disclosed. The compositions include factors present in an umbilical cord blood derived macrophage cell population culture medium which can promote maturation of oligodendrocytes to promote myelination of neurons. Clinal and non-clinical uses of the compositions are also disclosed.

Abstract: A colposcope includes an inserter including an elongated body defining an interior space and an image capture device configured to be selectively and slidably positioned within the interior space of the elongated body. The elongated body has a distal end portion and a proximal end portion. The distal end portion is substantially funnel shaped and has a distal end that includes first and second portions. The first portion includes a base at a first edge of the distal end, and the second portion includes a lip at a second edge of the distal end that is diametrically opposed from the first edge. The lip is positioned further from the proximal end portion than the base.

Abstract: Disclosed herein are purification matrices comprising adeno-associated virus (AAV)-binding polypeptides and methods of using the same.

Abstract: This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.

Abstract: This disclosure relates to hyperpolarized probes for use in magnetic resonance studies of biological systems.

Abstract: Aspects of the present disclosure describe techniques for using a parabolic Cassegrain-type reflector for ablation. For example, a system for ablation loading of a trap is described that includes a reflector having a hole aligned with a loading aperture of the trap, and an atomic source positioned at a focal point of the reflector, where one or more laser beams are reflected from a reflective front side of the reflector and focused on a surface of the atomic source to produce an atomic plume, and the atomic plume once produced passing through the hole in the reflector and through a loading aperture of the trap for loading the trap. A method for ablation loading of a trap within a chamber in a trapped ion system is also described.

Abstract: Disclosed herein are compositions, kits, and methods for identifying protein or miRNA biomarkers for dystonia, for treating a subject having a dystonia, for predicting penetrance of a dystonia in a subject, and for predicting responsiveness to a dystonia treatment.

Abstract: A method includes receiving, by a mobile computing device from an electroencephalogram (EEG) monitoring headset, an incoming wireless communication signal including an EEG data stream. The method may further include processing, by an application running on the mobile computing device, the received EEG data stream to determine at least one actionable command for at least one peripheral device. The method may also include transmitting, by the mobile computing device to the at least one peripheral device, at least one outgoing wireless communication signal including the at least one determined actionable command.

Abstract: A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.