Patents Assigned to Duke University
  • Patent number: 12279990
    Abstract: This present disclosure provides devices, systems, and methods relating to the modulation of tissue temperature. In particular, the present disclosure provides devices, systems, and methods for rapidly cooling or heating tissue in a subject as a therapeutic and/or prophylactic means for treating tissue that has been injured or damaged.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 22, 2025
    Assignee: DUKE UNIVERSITY
    Inventors: Rafael Eduardo Chaparro, Paolo Maccarini, Luis Fernando Gonzalez, Donald Pearce, Edward Lysk Wyckoff, III, Syed Faaiz Enam, Jikai Shen, Aliesha O'Raw, Rachel Yang
  • Patent number: 12280259
    Abstract: This present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for identifying optimized temporal patterns of spinal cord simulation (SCS) for minimizing variability in patient responses to SCS. The systems and methods of neuromodulation disclosed herein facilitate the treatment of neuropathic pain associated with various disease states and clinical indications.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: April 22, 2025
    Assignee: DUKE UNIVERSITY
    Inventors: Warren Grill, John Gilbert
  • Patent number: 12281862
    Abstract: A dual-mode heating and cooling system includes a dual-mode heating and cooling device including a cooling part and a heating part that are configured to be selectively exposed to sunlight in a cooling mode and a heating mode, respectively, with the cooling part configured to provide radiative cooling to a structure, and with the heating part configured to provide solar heating to the structure. The device may include a film with the cooling part and the heating part side-by-side on the film.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: April 22, 2025
    Assignee: Duke University
    Inventors: Pochun Hsu, Xiuqiang Li
  • Patent number: 12275986
    Abstract: Provided herein are methods for treating cancer in a subject comprising administering an ICB therapy to a subject having cancer, wherein the subject's cancer comprises one or more mutations in two or more genes associated with responsiveness to immune checkpoint blockade (ICB).
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: April 15, 2025
    Assignee: Duke University
    Inventors: Chuan-Yuan Li, Dong Pan
  • Publication number: 20250114350
    Abstract: The invention provides competitive inhibitors of farnesyl transferase, compositions comprising the competitive inhibitors of farnesyl transferase, and their use as antifungal agents and as agents for the prevention of the formation or growth of biofilms.
    Type: Application
    Filed: October 4, 2024
    Publication date: April 10, 2025
    Applicants: Regents of the University of Minnesota, Duke University
    Inventors: Mark Dewey Distefano, Feng Xu, Lorena S. Beese, Homme W. Hellinga, You Wang, Andrew A. Alspaugh
  • Patent number: 12263142
    Abstract: Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.
    Type: Grant
    Filed: August 29, 2023
    Date of Patent: April 1, 2025
    Assignee: Duke University
    Inventors: Suzanne E. Wardell, Erik R. Nelson, Donald P. McDonnell
  • Patent number: 12257308
    Abstract: Described herein are thermally responsive polymer-therapeutic molecule conjugates comprising a therapeutic molecule conjugated to a thermally responsive polymer with an acrylate, methacrylate, acrylamide, and/or methacrylamide backbone and a plurality of oligoethylene glycol side chains.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: March 25, 2025
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Imran Ozer
  • Patent number: 12259541
    Abstract: A microscopy system includes a primary lens and a planar array of micro-cameras. Each micro-camera of the planar array of micro-cameras has a field of view at an intermediate plane that overlaps at least one other micro-camera's field of view at the intermediate plane in a direction. The primary lens is disposed in a light path between the array of micro-cameras and a target area. In some cases, an overlap amount in the direction of the field of view at the intermediate plane for each micro-camera is at least 50%. A method of microscopy imaging includes directing light to a target area and simultaneously capturing a first set of images of the target area while the light illuminates the target area via a planar array of micro-cameras having a field of view at an intermediate plane disposed between a primary lens and the planar array of micro-cameras.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: March 25, 2025
    Assignee: DUKE UNIVERSITY
    Inventors: Xi Yang, Pavan Chandra Konda, Roarke Horstmeyer
  • Patent number: 12252750
    Abstract: The invention disclosed herein relates generally to the fields of microbiology, ecology and microfluidics. Particularly, the invention disclosed herein provides compositions and methods for isolating bacteria from complex microbial communities and measuring growth rates of the isolated bacteria in a given environmental condition.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: March 18, 2025
    Assignee: Duke University
    Inventors: Lawrence David, Rachael Bloom
  • Patent number: 12247090
    Abstract: The present disclosure describes, in part, an enzyme-mediated radical initiating system and methods of using the system to produce polymers, including polymeric hydrogels, at ambient conditions.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: March 11, 2025
    Assignee: Duke University
    Inventors: Teng Su, Jennifer West, Neica Joseph
  • Patent number: 12246179
    Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: March 11, 2025
    Assignee: Duke University
    Inventors: Warren M. Grill, Jr., Alan D. Dorval, II, Robert Strother
  • Patent number: 12247977
    Abstract: The present disclosure provides methods for determining the presence or absence of and/or the etiology of an acute respiratory viral infection in a subject, as well as methods of treating the subject based on the determination, by measuring on a platform the expression levels of a pre-defined set of gene products.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 11, 2025
    Assignee: Duke University
    Inventors: Thomas W. Burke, Ricardo Henao Giraldo, Erik Soderblom, Joseph Lucas, Christopher W. Woods, Geoffrey S. Ginsburg
  • Patent number: 12237162
    Abstract: Aspects of the present disclosure describe systems, methods, and structures that enable a compact, UHV ion trap system that can operate at temperatures above cryogenic temperatures. Ion trap systems in accordance with the present disclosure are surface treated and sealed while held in a UHV environment, where disparate components are joined via UHV seals, such as weld joints, compressible metal flanges, and UHV-compatible solder joints. As a result, no cryogenic pump is required, thereby enabling an extremely small-volume system.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: February 25, 2025
    Assignees: Duke University, ColdQuanta, Inc.
    Inventors: Jungsang Kim, Geert Vrijsen, Ismail Inlek, Tom Noel, Megan Ivory, Alexander Kato, Steve Hughes
  • Patent number: 12226483
    Abstract: A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: February 18, 2025
    Assignees: IMMUNOLIGHT, LLC, DUKE UNIVERSITY
    Inventors: Harold Walder, Frederic A. Bourke, Jr., Zakaryae Fathi, Wayne F. Beyer, Mark Oldham, Justus Adamson, Michael Nolan
  • Patent number: 12220451
    Abstract: Methods of generating an autologous cellular vaccine comprising monocytes or neutrophils and an antigenic polypeptide or nucleotide encoding the antigenic polypeptide are provided. The antigen-loaded cell-based vaccine compositions made using these methods are also provided. Methods of using the antigen-loaded cell-based vaccine compositions are also provided and these vaccines may be used to treat cancer. Kits for carrying out the methods described herein are also provided.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: February 11, 2025
    Assignee: Duke University
    Inventors: Michael D. Gunn, Min-Nung Huang
  • Patent number: 12221447
    Abstract: The presently disclosed subject matter is directed to compositions and methods for treating CaMKK2-mediated ophthalmic diseases, including but not limited to 1) ocular surface inflammatory diseases (OSIDs), including but not limited to ocular graft versus host disease, ocular cicatricial pemphigoid, vernal keratoconjunctivitis, allergic eye disease, meibomian gland dysfunction, aqueous tear deficiency (common dry eye disease), corneal scarring, and conjunctival scarring and fibrosis; 2) uveitis and other inflammatory diseases of the eye, including but not limited to keratitis, scleritis, iritis, iridocyclitis, intermediate uveitis, pars planitis, posterior uveitis, choroiditis, chorioretinitis, retinitis, or panuveitis of noninfectious, infectious, or idiopathic etiologies; and 3) “back of the eye” retinal diseases, which include dry age-related macular degeneration, neovascular age-related macular degeneration, diabetic retinopathy, retinal vascular diseases (e.g.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: February 11, 2025
    Assignee: Duke University
    Inventors: Scott W. Cousins, Priyatham S. Mettu, David M. Gooden
  • Patent number: 12215366
    Abstract: Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: February 4, 2025
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Isaac Hilton
  • Patent number: 12214056
    Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: February 4, 2025
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Sarina Madhavan, Christopher Nelson
  • Patent number: 12215345
    Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using the compositions for inducing gene expression of mammalian genes.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: February 4, 2025
    Assignee: Duke University
    Inventors: Pablo Perez-Pinera, Charles A. Gersbach
  • Patent number: D1071220
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: April 15, 2025
    Assignees: RESTOR3D, INC., DUKE UNIVERSITY
    Inventors: Andrew Todd Miller, Matthew Rexrode, Cambre Kelly, Ken Gall