Patents Assigned to Duke University
  • Patent number: 10416302
    Abstract: Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image capture rates due to lower I/O bandwidth requirements, and avoids the need for image compression hardware, as the image is captured in compressed form. Measuring the transformation of an emitted multimodal signal is one method of compressive imaging. Metamaterial antennas and transceivers are well suited for both emitting and receiving multimodal signals, and are thus prime candidates for compressive imaging.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: September 17, 2019
    Assignee: Duke University
    Inventors: David Smith, David Brady, Tom Driscoll, John Hunt, Alexander Mrozack, Matthew Reynolds, Daniel Marks
  • Patent number: 10410850
    Abstract: Aspects of the present disclosure describe systems, methods, and structures for compound-specific coding mass spectrometry wherein compound-specific masks/codes are positioned between an ion source and detector of a mass spectrometer.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: September 10, 2019
    Assignee: Duke University
    Inventors: Michael E. Gehm, Jeffrey T. Glass, Jason J. Amsden, Charles B. Parker
  • Patent number: 10407716
    Abstract: A sensor comprising a semiconductor layer having a two dimensional electron gas (2DEG) and an oxide layer in electronic contact with the semiconductor layer is provided. A method of detecting an analyte molecule using such sensor is also provided.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: September 10, 2019
    Assignee: Duke University
    Inventors: April S. Brown, Maria Losurdo, Chris Dwyer
  • Patent number: 10398743
    Abstract: Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: September 3, 2019
    Assignee: Duke University
    Inventors: Matthias Gromeier, John H. Sampson, Darell D. Bigner, Annick Desjardins, Henry S. Friedman
  • Publication number: 20190262402
    Abstract: Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 29, 2019
    Applicant: Duke University & Medical Center
    Inventor: Mary Louise Markert
  • Patent number: 10392611
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 27, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • Patent number: 10391330
    Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: August 27, 2019
    Assignees: IMMUNOLIGHT, LLC, DUKE UNIVERSITY
    Inventors: Frederic A. Bourke, Jr., Tuan Vo-Dinh, Harold Walder
  • Patent number: 10386479
    Abstract: Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image capture rates due to lower I/O bandwidth requirements, and avoids the need for image compression hardware, as the image is captured in compressed form. Measuring the transformation of an emitted multimodal signal is one method of compressive imaging. Metamaterial antennas and transceivers are well suited for both emitting and receiving multimodal signals, and are thus prime candidates for compressive imaging.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: August 20, 2019
    Assignee: Duke University
    Inventors: David Brady, Tom Driscoll, John Hunt, Daniel Marks, Alexander Mrozack, Matthew Reynolds, David R. Smith
  • Patent number: 10384071
    Abstract: System for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The system can be used in methods which can be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 20, 2019
    Assignees: IMMUNOLIGHT, LLC., DUKE UNIVERSITY
    Inventors: Tuan Vo-Dinh, Jonathan P. Scaffidi, Venkata Gopal Reddy Chada, Benoit Lauly, Yan Zhang, Molly K. Gregas, Ian Nicholas Stanton, Joshua T. Stecher, Michael J. Therien, Frederic A. Bourke, Jr., Harold Walder, Zak Fathi, Jennifer A. Ayres, Zhenyuan Zhang, Joseph H. Simmons, Stephen John Norton
  • Patent number: 10385115
    Abstract: Provided herein are fusion proteins including at least one binding polypeptide and at least one unstructured polypeptide. The fusion protein may further include at least one linker. Further provided are methods for determining the presence of a target in a sample, methods of treating a disease, methods of diagnosing a disease in a subject, and methods of determining the effectiveness of a treatment for a disease in a subject. The methods may include administering to the subject an effective amount of the fusion protein.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: August 20, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Mandana Manzari, Mareva Fevre
  • Publication number: 20190249157
    Abstract: Disclosed herein are genome editing systems and genetic constructs that targets a herpes simplex virus (HSV) viral gene comprising one Cas9 molecule, and a gRNA molecule, and compositions and cells comprising such genome editing systems and genetic constructs. Also provided are methods for using the genome editing systems, genetic constructs, compositions and cells for genome engineering (e.g., altering a HSV viral gene), and for preventing, treating or reducing HSV infection.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Applicants: EDITAS MEDICINE, INC., DUKE UNIVERSITY
    Inventors: Ari E. Friedland, Penrose O'Donnell, David A. Bumcrot, Bryan R. Cullen
  • Patent number: 10378056
    Abstract: The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 13, 2019
    Assignee: Duke University
    Inventors: Miklos D. Kertai, Mihai V. Podgoreanu, Joseph P. Mathew, Yi-Ju Li
  • Patent number: 10379112
    Abstract: A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: August 13, 2019
    Assignees: Advanced Liquid Logic, Inc., Duke University
    Inventors: Ramakrishna Sista, Vamsee K. Pamula, Michael G. Pollack, Vijay Srinivasan, Allen E. Eckhardt, Richard B. Fair
  • Patent number: 10370712
    Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: August 6, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: John P. Chute, Joseph R. Nevins, Joseph Lucas, Holly K. Dressman
  • Patent number: 10369189
    Abstract: The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides that when administered disrupt the physical interaction of TrkB with its signaling effector, phospholipase C?1 (PLC?1). The invention further provides method of treatment comprising administering phosphopeptides that uncouple TrkB from PLC?1 in order to prevent and/or ameliorate nervous system disorders such as epilepsy, anxiety, and seizures.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: August 6, 2019
    Assignee: Duke University
    Inventors: James O. McNamara, Xiao-Ping He, Yangzhong Huang, Bin Gu
  • Patent number: 10369110
    Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 6, 2019
    Assignees: BioSpecifics Technologies Corporation, Duke University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman
  • Patent number: 10371813
    Abstract: An imaging system as disclosed can include multiple bistatic radar sensors configured to transmit electromagnetic waves towards a surface of a target object and configured to measure the electromagnetic waves reflected from the surface of the target object. The imaging system includes a computing device that determines time of flight estimates based on the measured waves. The computing device can draw, within an image model for the target object, multiple candidate surface portions of the surface of the target object based on the TOF estimates and predetermined positions of the bistatic radar sensors. Further, the computing device can assign weights to the candidate surface portions. The computing device can determine points where the candidate surface portions meet with a predetermined probability based on the weights. The computing device is configured to define an estimated surface of the target object in the image model based on the determined points.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: August 6, 2019
    Assignee: Duke University
    Inventors: Orges Furxhi, Ruoyu Zhu, David J. Brady, Daniel Marks
  • Patent number: 10366492
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: July 30, 2019
    Assignee: Duke University
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 10364451
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 30, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • Publication number: 20190224305
    Abstract: Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.
    Type: Application
    Filed: July 12, 2017
    Publication date: July 25, 2019
    Applicant: Duke University
    Inventors: Nicholas Scott Heaton, Alfred Theodore Harding, Brook Elizabeth Heaton